Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1991 Mar;63(3):466–468. doi: 10.1038/bjc.1991.109

Arteriovenous shunting in patients with colorectal liver metastases.

J A Goldberg 1, J A Thomson 1, G McCurrach 1, J H Anderson 1, N Willmott 1, R G Bessent 1, J H McKillop 1, C S McArdle 1
PMCID: PMC1971851  PMID: 2003991

Abstract

The outlook for patients with colorectal liver metastases is poor. Microspheres have been combined with cytotoxics and administered via the hepatic artery in an attempt to improve tumour drug exposure within the liver. However, it has been suggested that arteriovenous connections might occur in association with intrahepatic tumours causing loss of regional advantage, and that the administration of microspheres further exacerbates arteriovenous shunting. In seven patients with colorectal liver metastases, base-line shunting was measured using a tracer quantity of radio-labelled albumin microspheres. The shunted fraction of a 'therapeutic quantity' of microspheres was subsequently measured in the same group of patients using albumin microspheres carrying a different radio-label. Base-line shunt for 0.5 x 10(6) microspheres was found to be 2.2 +/- 1.8% (mean +/- s.d.); the percentage shunt of a therapeutic quantity (40-80 x 10(6)) of microspheres was 3.0 +/- 0.8%. We conclude that arteriovenous shunting in patients with colorectal liver metastases is minimal, and is not significantly increased by the administration of therapeutic quantity of microspheres during regional chemotherapy.

Full text

PDF
466

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dakhil S., Ensminger W., Cho K., Niederhuber J., Doan K., Wheeler R. Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer. 1982 Aug 15;50(4):631–635. doi: 10.1002/1097-0142(19820815)50:4<631::aid-cncr2820500403>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  2. Ensminger W. D., Gyves J. W., Stetson P., Walker-Andrews S. Phase I study of hepatic arterial degradable starch microspheres and mitomycin. Cancer Res. 1985 Sep;45(9):4464–4467. [PubMed] [Google Scholar]
  3. Fujimoto S., Miyazaki M., Endoh F., Takahashi O., Shrestha R. D., Okui K., Morimoto Y., Terao K. Effects of intra-arterially infused biodegradable microspheres containing mitomycin C. Cancer. 1985 Feb 1;55(3):522–526. doi: 10.1002/1097-0142(19850201)55:3<522::aid-cncr2820550309>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  4. Goldberg J. A., Bradnam M. S., Kerr D. J., Haughton D. M., McKillop J. H., Bessent R. G., Willmott N., McArdle C. S., George W. D. Arteriovenous shunting of microspheres in patients with colorectal liver metastases: errors in assessment due to free pertechnetate, and the effect of angiotensin II. Nucl Med Commun. 1987 Dec;8(12):1033–1046. doi: 10.1097/00006231-198712000-00013. [DOI] [PubMed] [Google Scholar]
  5. Goldberg J. A., Kerr D. J., Willmott N., McKillop J. H., McArdle C. S. Pharmacokinetics and pharmacodynamics of locoregional 5 fluorouracil (5FU) in advanced colorectal liver metastases. Br J Cancer. 1988 Feb;57(2):186–189. doi: 10.1038/bjc.1988.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Herba M. J., Illescas F. F., Thirlwell M. P., Boos G. J., Rosenthall L., Atri M., Bret P. M. Hepatic malignancies: improved treatment with intraarterial Y-90. Radiology. 1988 Nov;169(2):311–314. doi: 10.1148/radiology.169.2.3174978. [DOI] [PubMed] [Google Scholar]
  7. McArdle C. S., Lewi H., Hansell D., Kerr D. J., McKillop J., Willmott N. Cytotoxic-loaded albumin microspheres: a novel approach to regional chemotherapy. Br J Surg. 1988 Feb;75(2):132–134. doi: 10.1002/bjs.1800750214. [DOI] [PubMed] [Google Scholar]
  8. Okamoto Y., Konno A., Togawa K., Kato T., Tamakawa Y., Amano Y. Arterial chemoembolization with cisplatin microcapsules. Br J Cancer. 1986 Mar;53(3):369–375. doi: 10.1038/bjc.1986.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Starkhammar H., Håkansson L., Morales O., Svedberg J. Effect of microspheres in intra-arterial chemotherapy. A study of arterio-venous shunting and passage of a labelled marker. Med Oncol Tumor Pharmacother. 1987;4(2):87–96. doi: 10.1007/BF02934945. [DOI] [PubMed] [Google Scholar]
  10. Thom A. K., Sigurdson E. R., Bitar M., Daly J. M. Regional hepatic arterial infusion of degradable starch microspheres increases fluorodeoxyuridine (FUdR) tumor uptake. Surgery. 1989 Mar;105(3):383–392. [PubMed] [Google Scholar]
  11. Willmott N., Chen Y., Goldberg J., Mcardle C., Florence A. T. Biodegradation rate of embolized protein microspheres in lung, liver and kidney of rats. J Pharm Pharmacol. 1989 Jul;41(7):433–438. doi: 10.1111/j.2042-7158.1989.tb06496.x. [DOI] [PubMed] [Google Scholar]
  12. Willmott N., Cummings J., Stuart J. F., Florence A. T. Adriamycin-loaded albumin microspheres: preparation, in vivo distribution and release in the rat. Biopharm Drug Dispos. 1985 Jan-Mar;6(1):91–104. doi: 10.1002/bdd.2510060111. [DOI] [PubMed] [Google Scholar]
  13. Ziessman H. A., Thrall J. H., Gyves J. W., Ensminger W. D., Niederhuber J. E., Tuscan M., Walker S. Quantitative hepatic arterial perfusion scintigraphy and starch microspheres in cancer chemotherapy. J Nucl Med. 1983 Oct;24(10):871–875. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES