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. 1991 Apr;63(4):583–586. doi: 10.1038/bjc.1991.135

Frequency and mechanism of Lewis antigen expression in human urinary bladder and colon carcinoma patients.

N C Langkilde 1, H Wolf 1, P Meldgård 1, T F Orntoft 1
PMCID: PMC1972368  PMID: 2021543

Abstract

Changes in the expression of Lewis antigens have been associated with cancer diseases, and recent results have pointed at a possible increased risk of cancer development among Lewis negative patients. The frequency of the erythrocyte Lewis phenotypes Le(a- b+), Le(a+ b-) and Le(a- b-) was analysed in patients suffering from urinary bladder cancer (82), colon cancer (21), and benign urological diseases (45). An increased frequency of Lewis negative individuals was found among colon cancer patients (P less than 0.004) and bladder cancer patients (P = 0.05). The Lewis negative phenotype was shown to be associated with unfavourable disease parameters: invasion (P less than 0.02) and high grade of atypia (P less than 0.01) in bladder cancer patients, and high Dukes stage (P less than 0.05) in colon cancer patients. alpha 1-4fucosyltransferase activity (Lewis transferase) was shown to be present in saliva from four out of eight erythrocyte Lewis negative cancer patients, indicating that some patients with advanced cancer disease may have converted from a Lewis positive to a Lewis negative phenotype.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bergkvist A., Ljungqvist A., Moberger G. Classification of bladder tumours based on the cellular pattern. Preliminary report of a clinical-pathological study of 300 cases with a minimum follow-up of eight years. Acta Chir Scand. 1965 Oct;130(4):371–378. [PubMed] [Google Scholar]
  2. Grollman E. F., Kobata A., Ginsburg V. An enzymatic basis for Lewis blood types in man. J Clin Invest. 1969 Aug;48(8):1489–1494. doi: 10.1172/JCI106115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hirano K., Kawa S., Oguchi H., Kobayashi T., Yonekura H., Ogata H., Homma T. Loss of Lewis antigen expression on erythrocytes in some cancer patients with high serum CA19-9 levels. J Natl Cancer Inst. 1987 Dec;79(6):1261–1268. [PubMed] [Google Scholar]
  4. Itzkowitz S. H., Yuan M., Ferrell L. D., Palekar A., Kim Y. S. Cancer-associated alterations of blood group antigen expression in human colorectal polyps. Cancer Res. 1986 Nov;46(11):5976–5984. [PubMed] [Google Scholar]
  5. Marcus D. M., Cass L. E. Glycosphingolipids with Lewis blood group activity: uptake by human erythrocytes. Science. 1969 May 2;164(3879):553–555. doi: 10.1126/science.164.3879.553. [DOI] [PubMed] [Google Scholar]
  6. Marr A. M., Donald A. S., Watkins W. M., Morgan W. T. Molecular and genetic aspects of human blood-group Le-b specificity. Nature. 1967 Sep 23;215(5108):1345–1349. doi: 10.1038/2151345a0. [DOI] [PubMed] [Google Scholar]
  7. Orntoft T. F., Wolf H., Watkins W. M. Activity of the human blood group ABO, Se, H, Le, and X gene-encoded glycosyltransferases in normal and malignant bladder urothelium. Cancer Res. 1988 Aug 1;48(15):4427–4433. [PubMed] [Google Scholar]
  8. SNEATH J. S., SNEATH P. H. Adsorption of blood-group substances from serum on to red cells. Br Med Bull. 1959 May;15(2):154–157. doi: 10.1093/oxfordjournals.bmb.a069741. [DOI] [PubMed] [Google Scholar]
  9. Schoentag R., Primus F. J., Kuhns W. ABH and Lewis blood group expression in colorectal carcinoma. Cancer Res. 1987 Mar 15;47(6):1695–1700. [PubMed] [Google Scholar]
  10. Sheinfeld J., Schaeffer A. J., Cordon-Cardo C., Rogatko A., Fair W. R. Association of the Lewis blood-group phenotype with recurrent urinary tract infections in women. N Engl J Med. 1989 Mar 23;320(12):773–777. doi: 10.1056/NEJM198903233201205. [DOI] [PubMed] [Google Scholar]
  11. Shen L., Grollman E. F., Ginsburg V. An enzymatic basis for secretor status and blood group substance specificity in humans. Proc Natl Acad Sci U S A. 1968 Jan;59(1):224–230. doi: 10.1073/pnas.59.1.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stigendal L., Olsson R., Rydberg L., Samuelsson B. E. Blood group lewis phenotype on erythrocytes and in saliva in alcoholic pancreatitis and chronic liver disease. J Clin Pathol. 1984 Jul;37(7):778–782. doi: 10.1136/jcp.37.7.778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Yazawa S., Asao T., Izawa H., Miyamoto Y., Matta K. L. The presence of CA19-9 in serum and saliva from Lewis blood-group negative cancer patients. Jpn J Cancer Res. 1988 Apr;79(4):538–543. doi: 10.1111/j.1349-7006.1988.tb01624.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Yazawa S., Madiyalakan R., Piver M. S., Matta K. L. Elevated activities of blood group Le gene dependent alpha(1----3)-L-fucosyltransferase in human saliva of Lewis negative patients with epithelial ovarian cancer. Cancer Lett. 1986 Aug;32(2):165–169. doi: 10.1016/0304-3835(86)90115-1. [DOI] [PubMed] [Google Scholar]

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