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. 1991 May;63(5):819–821. doi: 10.1038/bjc.1991.181

The diagnostic significance of lactate dehydrogenase isoenzymes in urinary cytology.

A Nishikawa 1, T Tanaka 1, T Takeuchi 1, S Fujihiro 1, H Mori 1
PMCID: PMC1972382  PMID: 2039708

Abstract

Lactate dehydrogenase (LDH) isoenzyme distribution was examined in 106 urine samples being tested cytologically for evidence of bladder cancer; the samples were selected to have less than 20 leucocytes and erythrocytes per high power field and the LDH pattern determined by electrophoresis. The Papanicolaou stained-smears showed 68 negative, 17 suspicious and 21 positive. The LDH M-fraction of the urinary supernatant in cytologically positive cases was significantly greater than in negative cases, although the latter included a few false negative samples. Some of the false negatives gave positive results for the LDH M-fraction; these results suggest that the determination of LDH isoenzymes in the urine is useful in diagnosing urinary tract cancers, including early stage, and for follow-up of patients with bladder cancers after surgical resection.

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Selected References

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