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. 1991 May;63(5):769–772. doi: 10.1038/bjc.1991.172

Medical history and the risk of multiple myeloma.

A Gramenzi 1, I Buttino 1, B D'Avanzo 1, E Negri 1, S Franceschi 1, C La Vecchia 1
PMCID: PMC1972384  PMID: 2039702

Abstract

The relationship between various diseases and immunisations and the risk of multiple myeloma was analysed using data from a hospital-based case-control study conducted in Northern Italy on 117 patients with multiple myeloma and 477 controls. Associations were observed for clinical history of scarlet fever (relative risk, RR = 2.0; 95% confidence interval, CI = 1.1-3.9), tuberculosis (RR = 2.3%; 95% CI = 0.9-5.7) and BCG immunisation (RR = 3.0; 95% CI = 1.4-6.4). The relative risk was 1.8 (95% CI = 0.9-3.5) for episodes of Herpes zoster infection, but most of the excess cases occurred within 10 years of diagnosis, suggesting that this might have been an early manifestation of the disease. No association emerged for common childhood viral infections or any other immunisation practice. When various classes of infectious or inflammatory diseases were grouped together according to their aetiology, there was a significant positive association with chronic bacterial illnesses (RR = 1.8; 95% CI = 1.1-2.8), and the relative risk estimates increased with the number of bacterial diseases. The trend in risk with number of diseases was significant (chi 21 = 4.5, P = 0.03). A negative association was found between allergic conditions and risk of multiple myeloma (RR = 0.6; 95% CI = 0.3-1.0).

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Selected References

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  1. Boffetta P., Stellman S. D., Garfinkel L. A case-control study of multiple myeloma nested in the American Cancer Society prospective study. Int J Cancer. 1989 Apr 15;43(4):554–559. doi: 10.1002/ijc.2910430404. [DOI] [PubMed] [Google Scholar]
  2. Cuzick J., De Stavola B. L. Autoimmune disorders and multiple myeloma. Int J Epidemiol. 1989 Mar;18(1):283–283. doi: 10.1093/ije/18.1.283. [DOI] [PubMed] [Google Scholar]
  3. Cuzick J., De Stavola B. Multiple myeloma--a case-control study. Br J Cancer. 1988 May;57(5):516–520. doi: 10.1038/bjc.1988.118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cuzick J. Radiation-induced myelomatosis. N Engl J Med. 1981 Jan 22;304(4):204–210. doi: 10.1056/NEJM198101223040404. [DOI] [PubMed] [Google Scholar]
  5. Cuzick J., Velez R., Doll R. International variations and temporal trends in mortality from multiple myeloma. Int J Cancer. 1983 Jul 15;32(1):13–19. doi: 10.1002/ijc.2910320104. [DOI] [PubMed] [Google Scholar]
  6. Gallagher R. P., Spinelli J. J., Elwood J. M., Skippen D. H. Allergies and agricultural exposure as risk factors for multiple myeloma. Br J Cancer. 1983 Dec;48(6):853–857. doi: 10.1038/bjc.1983.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hakulinen T., Isomaki H., Knekt P. Rheumatoid arthritis and cancer studies based on linking nationwide registries in Finland. Am J Med. 1985 Jan 21;78(1A):29–32. doi: 10.1016/0002-9343(85)90242-6. [DOI] [PubMed] [Google Scholar]
  8. Kelly J. P., Rosenberg L., Kaufman D. W., Shapiro S. Reliability of personal interview data in a hospital-based case-control study. Am J Epidemiol. 1990 Jan;131(1):79–90. doi: 10.1093/oxfordjournals.aje.a115488. [DOI] [PubMed] [Google Scholar]
  9. Koepsell T. D., Daling J. R., Weiss N. S., Taylor J. W., Olshan A. F., Lyon J. L., Swanson G. M., Child M. Antigenic stimulation and the occurrence of multiple myeloma. Am J Epidemiol. 1987 Dec;126(6):1051–1062. doi: 10.1093/oxfordjournals.aje.a114744. [DOI] [PubMed] [Google Scholar]
  10. La Vecchia C., Negri E., D'Avanzo B., Boyle P., Franceschi S. Medical history and primary liver cancer. Cancer Res. 1990 Oct 1;50(19):6274–6277. [PubMed] [Google Scholar]
  11. La Vecchia C., Negri E., D'Avanzo B., Franceschi S. Occupation and lymphoid neoplasms. Br J Cancer. 1989 Sep;60(3):385–388. doi: 10.1038/bjc.1989.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. La Vecchia C., Negri E., Decarli A., Fasoli M., Cislaghi C. Cancer mortality in Italy: an overview of age-specific and age-standardised trends from 1955 to 1984. Tumori. 1990 Apr 30;76(2):87–166. doi: 10.1177/030089169007600202. [DOI] [PubMed] [Google Scholar]
  13. Levi F., Negri E., La Vecchia C., Te V. C. Socioeconomic groups and cancer risk at death in the Swiss Canton of Vaud. Int J Epidemiol. 1988 Dec;17(4):711–717. doi: 10.1093/ije/17.4.711. [DOI] [PubMed] [Google Scholar]
  14. Linet M. S., Harlow S. D., McLaughlin J. K. A case-control study of multiple myeloma in whites: chronic antigenic stimulation, occupation, and drug use. Cancer Res. 1987 Jun 1;47(11):2978–2981. [PubMed] [Google Scholar]
  15. Linet M. S., Mclaughlin J. K., Harlow S. D., Fraumeni J. F. Family history of autoimmune disorders and cancer in multiple myeloma. Int J Epidemiol. 1988 Sep;17(3):512–513. doi: 10.1093/ije/17.3.512. [DOI] [PubMed] [Google Scholar]
  16. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  17. MacMahon B. Epidemiology of Hodgkin's disease. Cancer Res. 1966 Jun;26(6):1189–1201. [PubMed] [Google Scholar]
  18. Mack T. M., Yu M. C., Hanisch R., Henderson B. E. Pancreas cancer and smoking, beverage consumption, and past medical history. J Natl Cancer Inst. 1986 Jan;76(1):49–60. [PubMed] [Google Scholar]
  19. Mills P. K., Beeson W. L., Abbey D. E., Fraser G. E., Phillips R. L. Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists. Cancer. 1988 Jun 15;61(12):2578–2585. doi: 10.1002/1097-0142(19880615)61:12<2578::aid-cncr2820611232>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  20. Nandakumar A., Armstrong B. K., de Klerk N. H. Multiple myeloma in Western Australia: a case-control study in relation to occupation, father's occupation, socioeconomic status and country of birth. Int J Cancer. 1986 Feb 15;37(2):223–226. doi: 10.1002/ijc.2910370209. [DOI] [PubMed] [Google Scholar]
  21. Pearce N. E., Smith A. H., Howard J. K., Sheppard R. A., Giles H. J., Teague C. A. Case-control study of multiple myeloma and farming. Br J Cancer. 1986 Sep;54(3):493–500. doi: 10.1038/bjc.1986.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Penny R., Hughes S. Repeated stimulation of the reticuloendothelial system and the development of plasma-cell dyscrasias. Lancet. 1970 Jan 10;1(7637):77–78. doi: 10.1016/s0140-6736(70)91859-3. [DOI] [PubMed] [Google Scholar]
  23. Rosenblatt J., Hall C. A. Plasma-cell dyscrasia following prolonged stimulation of reticuloendothelial system. Lancet. 1970 Feb 7;1(7641):301–302. doi: 10.1016/s0140-6736(70)90666-5. [DOI] [PubMed] [Google Scholar]
  24. Steineck G., Wiklund K. Multiple myeloma in Swedish agricultural workers. Int J Epidemiol. 1986 Sep;15(3):321–325. doi: 10.1093/ije/15.3.321. [DOI] [PubMed] [Google Scholar]
  25. Turesson I., Zettervall O., Cuzick J., Waldenstrom J. G., Velez R. Comparison of trends in the incidence of multiple myeloma in Malmö, Sweden, and other countries, 1950-1979. N Engl J Med. 1984 Feb 16;310(7):421–424. doi: 10.1056/NEJM198402163100703. [DOI] [PubMed] [Google Scholar]
  26. Williams A. R., Weiss N. S., Koepsell T. D., Lyon J. L., Swanson G. M. Infectious and noninfectious exposures in the etiology of light chain myeloma: a case-control study. Cancer Res. 1989 Jul 15;49(14):4038–4041. [PubMed] [Google Scholar]

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