Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1991 May;63(5):723–726. doi: 10.1038/bjc.1991.163

Differences in vascular response between primary and transplanted tumours.

S B Field 1, S Needham 1, I A Burney 1, R J Maxwell 1, J E Coggle 1, J R Griffiths 1
PMCID: PMC1972409  PMID: 1645562

Abstract

The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using 31P Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0.001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors' opinion, the most likely cause is that it results from an artefact of transplantation.

Full text

PDF

Images in this article

725Figure 3
on p.725

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Babbs C. F., DeWitt D. P., Voorhees W. D., McCaw J. S., Chan R. C. Theoretical feasibility of vasodilator-enhanced local tumor heating. Eur J Cancer Clin Oncol. 1982 Nov;18(11):1137–1146. doi: 10.1016/0277-5379(82)90095-5. [DOI] [PubMed] [Google Scholar]
  2. Bhujwalla Z. M., Tozer G. M., Field S. B., Proctor E., Busza A., Williams S. R. The combined measurement of blood flow and metabolism in RIF-1 tumours in vivo. A study using H2 flow and 31P NMR spectroscopy. NMR Biomed. 1990 Aug;3(4):178–183. doi: 10.1002/nbm.1940030406. [DOI] [PubMed] [Google Scholar]
  3. CATER D. B., GRIGSON C. M., WATKINSON D. A. Changes of oxygen tension in tumours induced by vasoconstrictor and vasodilator drugs. Acta radiol. 1962 Dec;58:401–434. doi: 10.3109/00016926209169582. [DOI] [PubMed] [Google Scholar]
  4. Chaplin D. J., Acker B. The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: evidence for therapeutic gain. Int J Radiat Oncol Biol Phys. 1987 Apr;13(4):579–585. doi: 10.1016/0360-3016(87)90075-7. [DOI] [PubMed] [Google Scholar]
  5. Chaplin D. J., Olive P. L., Durand R. E. Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res. 1987 Jan 15;47(2):597–601. [PubMed] [Google Scholar]
  6. Falk P. Differences in vascular pattern between the spontaneous and the transplanted C3H mouse mammary carcinoma. Eur J Cancer Clin Oncol. 1982 Feb;18(2):155–165. doi: 10.1016/0277-5379(82)90059-1. [DOI] [PubMed] [Google Scholar]
  7. Falk P. The vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia. Eur J Cancer. 1980 Feb;16(2):203–217. doi: 10.1016/0014-2964(80)90152-8. [DOI] [PubMed] [Google Scholar]
  8. Folkman J. Proceedings: Tumor angiogenesis factor. Cancer Res. 1974 Aug;34(8):2109–2113. [PubMed] [Google Scholar]
  9. Hill S. A., Smith K. A., Denekamp J. Reduced thermal sensitivity of the vasculature in a slowly growing tumour. Int J Hyperthermia. 1989 May-Jun;5(3):359–370. doi: 10.3109/02656738909140462. [DOI] [PubMed] [Google Scholar]
  10. Horsman M. R., Christensen K. L., Overgaard J. Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo. Int J Hyperthermia. 1989 Mar-Apr;5(2):123–136. doi: 10.3109/02656738909140442. [DOI] [PubMed] [Google Scholar]
  11. Jain R. K. Determinants of tumor blood flow: a review. Cancer Res. 1988 May 15;48(10):2641–2658. [PubMed] [Google Scholar]
  12. Kruuv J. A., Inch W. R., McCredie J. A. Blood flow and oxygenation of tumors in mice. II. Effects of vasodilator drugs. Cancer. 1967 Jan;20(1):60–65. doi: 10.1002/1097-0142(1967)20:1<60::aid-cncr2820200109>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  13. McCredie J. A., Inch W. R., Sutherland R. M. Differences in growth and morphology between the spontaneous C3H mammary carcinoma in the mouse and its syngeneic transplants. Cancer. 1971 Mar;27(3):635–642. doi: 10.1002/1097-0142(197103)27:3<635::aid-cncr2820270319>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  14. Okunieff P., Kallinowski F., Vaupel P., Neuringer L. J. Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P-nuclear magnetic resonance spectroscopy. J Natl Cancer Inst. 1988 Jul 20;80(10):745–750. doi: 10.1093/jnci/80.10.745. [DOI] [PubMed] [Google Scholar]
  15. Reinhold H. S., Endrich B. Tumour microcirculation as a target for hyperthermia. Int J Hyperthermia. 1986 Apr-Jun;2(2):111–137. doi: 10.3109/02656738609012389. [DOI] [PubMed] [Google Scholar]
  16. Stratford I. J., Adams G. E., Godden J., Howells N. Induction of tumour hypoxia post-irradiation: a method for increasing the sensitizing efficiency of misonidazole and RSU 1069 in vivo. Int J Radiat Biol. 1989 Mar;55(3):411–422. doi: 10.1080/09553008914550451. [DOI] [PubMed] [Google Scholar]
  17. THOMLINSON R. H., GRAY L. H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955 Dec;9(4):539–549. doi: 10.1038/bjc.1955.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Tozer G. M., Morris C. C. Blood flow and blood volume in a transplanted rat fibrosarcoma: comparison with various normal tissues. Radiother Oncol. 1990 Feb;17(2):153–165. doi: 10.1016/0167-8140(90)90103-4. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES