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. 1991 Jun;63(6):846–850. doi: 10.1038/bjc.1991.188

Lipid mobilising factors specifically associated with cancer cachexia.

S A Beck 1, M J Tisdale 1
PMCID: PMC1972519  PMID: 2069843

Abstract

Both urine and plasma from mice and humans with cancer cachexia have been shown to contain higher levels of lipid mobilising activity than normal controls, even after acute starvation. There was no significant increase in the urinary lipid mobilising activity of either mice or humans after acute starvation, suggesting that the material in the cachectic situation was probably not due to an elevation of hormones normally associated with the catabolic state in starvation. Further characterisation of the lipid mobilising activity in the urine of cachectic mice using Sephadex G50 exclusion chromatography showed four distinct peaks of activity of apparent molecular weights of greater than 20, 3, 1.5 and less than 0.7 kDa. No comparable peaks of activity were found in the urine of a non tumour-bearing mouse. The high molecular weight activity was probably formed by aggregation of low molecular weight material, since treatment with 0.5 M NaCl caused dissociation to material with a broad spectrum of molecular weights between 3 and 0.7 kDa. Lipolytic species of similar molecular weights were also found in the urine of cachectic cancer patients, but not in normal urine even after 24 h starvation. The lipid mobilising species may be responsible for catabolism of host adipose tissue in the cachectic state.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck S. A., Tisdale M. J. Production of lipolytic and proteolytic factors by a murine tumor-producing cachexia in the host. Cancer Res. 1987 Nov 15;47(22):5919–5923. [PubMed] [Google Scholar]
  2. Beutler B., Cerami A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature. 1986 Apr 17;320(6063):584–588. doi: 10.1038/320584a0. [DOI] [PubMed] [Google Scholar]
  3. Bibby M. C., Double J. A., Ali S. A., Fearon K. C., Brennan R. A., Tisdale M. J. Characterization of a transplantable adenocarcinoma of the mouse colon producing cachexia in recipient animals. J Natl Cancer Inst. 1987 Mar;78(3):539–546. [PubMed] [Google Scholar]
  4. Brennan M. F. Uncomplicated starvation versus cancer cachexia. Cancer Res. 1977 Jul;37(7 Pt 2):2359–2364. [PubMed] [Google Scholar]
  5. Brenneman D. E., Spector A. A. Utilization of ascites plasma very low density lipoprotein triglycerides by Ehrlich cells. J Lipid Res. 1974 Jul;15(4):309–316. [PubMed] [Google Scholar]
  6. Chlebowski R. T. Critical evaluation of the role of nutritional support with chemotherapy. Cancer. 1985 Jan 1;55(1 Suppl):268–272. doi: 10.1002/1097-0142(19850101)55:1+<268::aid-cncr2820551311>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  7. DeWys W. D., Costa G., Henkin R. Clinical parameters related to anorexia. Cancer Treat Rep. 1981;65 (Suppl 5):49–52. [PubMed] [Google Scholar]
  8. Groundwater P., Beck S. A., Barton C., Adamson C., Ferrier I. N., Tisdale M. J. Alteration of serum and urinary lipolytic activity with weight loss in cachectic cancer patients. Br J Cancer. 1990 Nov;62(5):816–821. doi: 10.1038/bjc.1990.384. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Inagaki J., Rodriguez V., Bodey G. P. Proceedings: Causes of death in cancer patients. Cancer. 1974 Feb;33(2):568–573. doi: 10.1002/1097-0142(197402)33:2<568::aid-cncr2820330236>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  10. Kannan R., Lyon I., Baker N. Dietary control of lipogenesis in vivo in host tissues and tumors of mice bearing Ehrlich ascites carcinoma. Cancer Res. 1980 Dec;40(12):4606–4611. [PubMed] [Google Scholar]
  11. Kawakami M., Cerami A. Studies of endotoxin-induced decrease in lipoprotein lipase activity. J Exp Med. 1981 Sep 1;154(3):631–639. doi: 10.1084/jem.154.3.631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kekwick A., Pawan G. L. Fat mobilizing substance (FMS). Metabolism. 1967 Sep;16(9):787–796. doi: 10.1016/0026-0495(67)90181-3. [DOI] [PubMed] [Google Scholar]
  13. Kitada S., Hays E. F., Mead J. F. Characterization of a lipid mobilizing factor from tumors. Prog Lipid Res. 1981;20:823–826. doi: 10.1016/0163-7827(81)90155-7. [DOI] [PubMed] [Google Scholar]
  14. Kitada S., Hays E. F., Mead J. F., Zabin I. Lipolysis induction in adipocytes by a protein from tumor cells. J Cell Biochem. 1982;20(4):409–416. doi: 10.1002/jcb.240200410. [DOI] [PubMed] [Google Scholar]
  15. Lundholm K., Edström S., Ekman L., Karlberg I., Scherstén T. Metabolism in peripheral tissues in cancer patients. Cancer Treat Rep. 1981;65 (Suppl 5):79–83. [PubMed] [Google Scholar]
  16. Lähdevirta J., Maury C. P., Teppo A. M., Repo H. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med. 1988 Sep;85(3):289–291. doi: 10.1016/0002-9343(88)90576-1. [DOI] [PubMed] [Google Scholar]
  17. Mahony S. M., Beck S. A., Tisdale M. J. Comparison of weight loss induced by recombinant tumour necrosis factor with that produced by a cachexia-inducing tumour. Br J Cancer. 1988 Apr;57(4):385–389. doi: 10.1038/bjc.1988.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Masuno H., Yamasaki N., Okuda H. Purification and characterization of a lipolytic factor (toxohormone-L) from cell-free fluid of ascites sarcoma 180. Cancer Res. 1981 Jan;41(1):284–288. [PubMed] [Google Scholar]
  19. Mermier P., Baker N. Flux of free fatty acids among host tissues, ascites fluid, and Ehrlich ascites carcinoma cells. J Lipid Res. 1974 Jul;15(4):339–351. [PubMed] [Google Scholar]
  20. Oliff A., Defeo-Jones D., Boyer M., Martinez D., Kiefer D., Vuocolo G., Wolfe A., Socher S. H. Tumors secreting human TNF/cachectin induce cachexia in mice. Cell. 1987 Aug 14;50(4):555–563. doi: 10.1016/0092-8674(87)90028-6. [DOI] [PubMed] [Google Scholar]
  21. Sauer L. A., Dauchy R. T. Blood nutrient concentrations and tumor growth in vivo in rats: relationships during the onset of an acute fast. Cancer Res. 1987 Feb 15;47(4):1065–1068. [PubMed] [Google Scholar]
  22. Sauer L. A., Dauchy R. T. Stimulation of tumor growth in adult rats in vivo during acute streptozotocin-induced diabetes. Cancer Res. 1987 Apr 1;47(7):1756–1761. [PubMed] [Google Scholar]
  23. Scuderi P., Sterling K. E., Lam K. S., Finley P. R., Ryan K. J., Ray C. G., Petersen E., Slymen D. J., Salmon S. E. Raised serum levels of tumour necrosis factor in parasitic infections. Lancet. 1986 Dec 13;2(8520):1364–1365. doi: 10.1016/s0140-6736(86)92007-6. [DOI] [PubMed] [Google Scholar]
  24. Selby P., Hobbs S., Viner C., Jackson E., Jones A., Newell D., Calvert A. H., McElwain T., Fearon K., Humphreys J. Tumour necrosis factor in man: clinical and biological observations. Br J Cancer. 1987 Dec;56(6):803–808. doi: 10.1038/bjc.1987.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Socher S. H., Martinez D., Craig J. B., Kuhn J. G., Oliff A. Tumor necrosis factor not detectable in patients with clinical cancer cachexia. J Natl Cancer Inst. 1988 Jun 15;80(8):595–598. doi: 10.1093/jnci/80.8.595. [DOI] [PubMed] [Google Scholar]
  26. Spector A. A. Fatty acid metabolism in tumors. Prog Biochem Pharmacol. 1975;10:42–75. [PubMed] [Google Scholar]
  27. Wesdorp R. I., Krause R., von Meyenfeldt M. F. Cancer cachexia and its nutritional implications. Br J Surg. 1983 Jun;70(6):352–355. doi: 10.1002/bjs.1800700615. [DOI] [PubMed] [Google Scholar]

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