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. 1991 Jun;63(6):971–974. doi: 10.1038/bjc.1991.212

The effect of long acting somatostatin analogue SMS 201.995 therapy on tumour kinetic measurements and serum tumour marker concentrations in primary rectal cancer.

S Y Iftikhar 1, S A Watson 1, D L Morris 1
PMCID: PMC1972528  PMID: 2069853

Abstract

Twelve patients with rectal carcinoma were treated for 2 weeks with the somatostatin analogue SMS 201.995. Effects of this therapy were assessed using serum marker concentration, Ki67 and gastrin-immunoreactivity of the primary tumour. In four out of 12 patients, a significant decrease in Ki67 immunoreactivity was seen during SMS 201.995 treatment while in the remaining eight patients there was no significant change in Ki67 expression. Four patients had elevated pretreatment serum carcinoembryonic antigen (CEA) levels. In two of these four patients, serum CEA levels fell modestly during SMS 201.995 therapy. This is the first clinical evidence that a somatostatin analogue can inhibit the growth of some colorectal cancers.

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Selected References

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  1. Armitage N. C., Robins R. A., Evans D. F., Turner D. R., Baldwin R. W., Hardcastle J. D. The influence of tumour cell DNA abnormalities on survival in colorectal cancer. Br J Surg. 1985 Oct;72(10):828–830. doi: 10.1002/bjs.1800721018. [DOI] [PubMed] [Google Scholar]
  2. Besterman H. S., Adrian T. E., Mallinson C. N., Christofides N. D., Sarson D. L., Pera A., Lombardo L., Modigliani R., Bloom S. R. Gut hormone release after intestinal resection. Gut. 1982 Oct;23(10):854–861. doi: 10.1136/gut.23.10.854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bouzubar N., Walker K. J., Griffiths K., Ellis I. O., Elston C. W., Robertson J. F., Blamey R. W., Nicholson R. I. Ki67 immunostaining in primary breast cancer: pathological and clinical associations. Br J Cancer. 1989 Jun;59(6):943–947. doi: 10.1038/bjc.1989.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dembiński A., Warzecha Z., Konturek S. J., Schally A. V. Effect of somatostatin on the growth of gastrointestinal mucosa and pancreas in rats. Role of endogenous gastrin. Gut. 1987;28 (Suppl):227–232. doi: 10.1136/gut.28.suppl.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Elwyn K. E., Jones R. D., Romsdahl M. M. Inhibitory effects of secretin on gastrin-stimulated rat colon neoplasms. Cancer. 1985 Mar 15;55(6):1186–1189. doi: 10.1002/1097-0142(19850315)55:6<1186::aid-cncr2820550608>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  6. Gerdes J., Dallenbach F., Lennert K., Lemke H., Stein H. Growth fractions in malignant non-Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki-67. Hematol Oncol. 1984 Oct-Dec;2(4):365–371. doi: 10.1002/hon.2900020406. [DOI] [PubMed] [Google Scholar]
  7. Gerdes J., Lemke H., Baisch H., Wacker H. H., Schwab U., Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984 Oct;133(4):1710–1715. [PubMed] [Google Scholar]
  8. Lamberts S. W., Zweens M., Klijn J. G., van Vroonhoven C. C., Stefanko S. Z., Del Pozo E. The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201-995 in patients with prolactinomas and acromegaly. Clin Endocrinol (Oxf) 1986 Aug;25(2):201–212. doi: 10.1111/j.1365-2265.1986.tb01683.x. [DOI] [PubMed] [Google Scholar]
  9. McGregor D. B., Jones R. D., Karlin D. A., Romsdahl M. M. Trophic effects of gastrin on colorectal neoplasms in the rat. Ann Surg. 1982 Feb;195(2):219–223. doi: 10.1097/00000658-198202000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Morris D. L., Watson S. A., Durrant L. G., Harrison J. D. Hormonal control of gastric and colorectal cancer in man. Gut. 1989 Apr;30(4):425–429. doi: 10.1136/gut.30.4.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Quentmeier A., Schlag P., Hohenberger P., Schwarz V., Abel U. Assessment of serial carcinoembryonic antigen: determinations to monitor the therapeutic progress and prognosis of metastatic liver disease treated by regional chemotherapy. J Surg Oncol. 1989 Feb;40(2):112–118. doi: 10.1002/jso.2930400211. [DOI] [PubMed] [Google Scholar]
  12. Roberts P. J. Tumour markers in colorectal cancer. Scand J Gastroenterol Suppl. 1988;149:50–58. doi: 10.3109/00365528809096956. [DOI] [PubMed] [Google Scholar]
  13. Savage A. P., Calam J., Wood C. B., Bloom S. R. SMS 201-995 treatment and advanced intestinal cancer: a pilot study. Aliment Pharmacol Ther. 1987 Apr;1(2):133–139. doi: 10.1111/j.1365-2036.1987.tb00612.x. [DOI] [PubMed] [Google Scholar]
  14. Shepherd N. A., Richman P. I., England J. Ki-67 derived proliferative activity in colorectal adenocarcinoma with prognostic correlations. J Pathol. 1988 Jul;155(3):213–219. doi: 10.1002/path.1711550306. [DOI] [PubMed] [Google Scholar]
  15. Sirinek K. R., Levine B. A., Moyer M. P. Pentagastrin stimulates in vitro growth of normal and malignant human colon epithelial cells. Am J Surg. 1985 Jan;149(1):35–39. doi: 10.1016/s0002-9610(85)80006-4. [DOI] [PubMed] [Google Scholar]
  16. Smith J. P., Solomon T. E. Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. Gastroenterology. 1988 Dec;95(6):1541–1548. doi: 10.1016/s0016-5085(88)80075-1. [DOI] [PubMed] [Google Scholar]
  17. Walker R. A., Camplejohn R. S. Comparison of monoclonal antibody Ki-67 reactivity with grade and DNA flow cytometry of breast carcinomas. Br J Cancer. 1988 Mar;57(3):281–283. doi: 10.1038/bjc.1988.60. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Watson S. A., Durrant L. G., Crosbie J. D., Morris D. L. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin. Int J Cancer. 1989 Apr 15;43(4):692–696. doi: 10.1002/ijc.2910430425. [DOI] [PubMed] [Google Scholar]
  19. Williamson R. C., Bauer F. L., Oscarson J. E., Ross J. S., Malt R. A. Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel. Cancer Res. 1978 Oct;38(10):3212–3217. [PubMed] [Google Scholar]

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