Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1984 Jan;49(1):97–101. doi: 10.1038/bjc.1984.15

Methotrexate enterotoxicity: influence of drug dose and timing in the rat.

C R Pinkerton, P J Milla
PMCID: PMC1976680  PMID: 6691903

Full text

PDF
97

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baird G. M., Dossetor J. F. Methotrexate enteropathy. Lancet. 1981 Jan 17;1(8212):164–164. doi: 10.1016/s0140-6736(81)90760-1. [DOI] [PubMed] [Google Scholar]
  2. Baskerville A., Batter-Hatton D. Intestinal lesions induced experimentally by methotrexate. Br J Exp Pathol. 1977 Dec;58(6):663–669. [PMC free article] [PubMed] [Google Scholar]
  3. Craft A. W., Kay H., Lawson D. N., McElwain T. J. Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia. Br Med J. 1977 Dec 10;2(6101):1511–1512. doi: 10.1136/bmj.2.6101.1511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Farber E. Biochemical pathology. Annu Rev Pharmacol. 1971;11:71–96. doi: 10.1146/annurev.pa.11.040171.000443. [DOI] [PubMed] [Google Scholar]
  5. Gwavava N. J., Pinkerton C. R., Glasgow J. F., Sloan J. M., Bridges J. M. Small bowel enterocyte abnormalities caused by methotrexate treatment in acute lymphoblastic leukaemia of childhood. J Clin Pathol. 1981 Jul;34(7):790–795. doi: 10.1136/jcp.34.7.790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harries J. T., Sladen G. E. The effects of different bile salts on the absorption of fluid, electrolytes, and monosaccharides in the small intestine of the rat in vivo. Gut. 1972 Aug;13(8):596–603. doi: 10.1136/gut.13.8.596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jolly L. E., Jr, Fletcher H. P. The effect of repeated oral dosing of methotrexate on its intestinal absorption in the rat. Toxicol Appl Pharmacol. 1977 Jan;39(1):23–32. doi: 10.1016/0041-008x(77)90173-9. [DOI] [PubMed] [Google Scholar]
  8. Lewis I. J., Mainwaring D., Martin J. Enteropathy complicating maintenance therapy in acute lymphoblastic leukaemia. Arch Dis Child. 1982 Sep;57(9):663–667. doi: 10.1136/adc.57.9.663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pinkerton C. R., Cameron C. H., Sloan J. M., Glasgow J. F., Gwevava N. J. Jejunal crypt cell abnormalities associated with methotrexate treatment in children with acute lymphoblastic leukaemia. J Clin Pathol. 1982 Nov;35(11):1272–1277. doi: 10.1136/jcp.35.11.1272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pinkerton C. R., Glasgow J. F., Bridges J. M., Welshman S. G. Enterotoxic effect of methotrexate: does it influence the drug's absorption in children with acute lymphoblastic leukaemia? Br Med J (Clin Res Ed) 1981 Apr 18;282(6272):1276–1277. doi: 10.1136/bmj.282.6272.1276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Robinson J. W., Antonioli J. A., Vannotti A. The effect of oral methotrexate on the rat intestine. Biochem Pharmacol. 1966 Oct;15(10):1479–1489. doi: 10.1016/0006-2952(66)90193-6. [DOI] [PubMed] [Google Scholar]
  12. Shaw M. T., Spector M. H., Ladman A. J. Effects of cancer, radiotherapy and cytotoxic drugs on intestinal structure and function. Cancer Treat Rev. 1979 Sep;6(3):141–151. doi: 10.1016/s0305-7372(79)80066-3. [DOI] [PubMed] [Google Scholar]
  13. TRIER J. S. Morphologic alterations induced by methotrexate in the mucosa of human proximal intestine. I. Serial observations by light microscopy. Gastroenterology. 1962 Mar;42:295–305. [PubMed] [Google Scholar]
  14. Taminiau J. A., Gall D. G., Hamilton J. R. Response of the rat small-intestine epithelium to methotrexate. Gut. 1980 Jun;21(6):486–492. doi: 10.1136/gut.21.6.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. VITALE J. J., ZAMCHECK N., DIGIORGIO J., HEGSTED D. M. Effects of aminopterin administration on the respiration and morphology of the gastrointestinal mucosa of rats. J Lab Clin Med. 1954 Apr;43(4):583–594. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES