Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1984 Mar;49(3):357–361. doi: 10.1038/bjc.1984.56

In vivo nuclear magnetic resonance spectroscopy of a transplanted brain tumour.

T H Koeze, P L Lantos, R A Iles, R E Gordon
PMCID: PMC1976753  PMID: 6704312

Abstract

In vivo nuclear magnetic resonance 31P spectroscopy was used to demonstrate different patterns of high energy phosphate metabolism in a group of malignant tumours of glial origin. In some of the more malignant tumours a decrease in adenylate energy charge was found. This was associated with a decline in phosphocreatine and an increase in sugar phosphate and inorganic phosphorus.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ackerman J. J., Grove T. H., Wong G. G., Gadian D. G., Radda G. K. Mapping of metabolites in whole animals by 31P NMR using surface coils. Nature. 1980 Jan 10;283(5743):167–170. doi: 10.1038/283167a0. [DOI] [PubMed] [Google Scholar]
  2. Claisse P. J., Roscoe J. P., Lantos P. L. Cellular heterogeneity in an ethylnitrosourea-induced glioma: malignancy, karyology and other properties of tumour cell types. Br J Exp Pathol. 1979 Apr;60(2):209–224. [PMC free article] [PubMed] [Google Scholar]
  3. Davaki P., Lantos P. L. Morphological analysis of malignancy: a comparative study of transplanted brain tumours. Br J Exp Pathol. 1980 Dec;61(6):655–660. [PMC free article] [PubMed] [Google Scholar]
  4. Davaki P., Lantos P. L. The development of brain tumours produced in rats by the intracerebral injection of neoplastic glial cells: a fine structural study. Neuropathol Appl Neurobiol. 1981 Jan-Feb;7(1):49–61. doi: 10.1111/j.1365-2990.1981.tb00231.x. [DOI] [PubMed] [Google Scholar]
  5. Griffiths J. R., Iles R. A. Nuclear magnetic resonance--a 'magnetic eye' on metabolism. Clin Sci (Lond) 1980 Oct;59(4):225–230. doi: 10.1042/cs0590225. [DOI] [PubMed] [Google Scholar]
  6. Griffiths J. R., Stevens A. N., Iles R. A., Gordon R. E., Shaw D. 31P-NMR investigation of solid tumours in the living rat. Biosci Rep. 1981 Apr;1(4):319–325. doi: 10.1007/BF01114871. [DOI] [PubMed] [Google Scholar]
  7. Gupta R. K., Yushok W. D. Noninvasive 31P NMR probes of free Mg2+, MgATP, and MgADP in intact Ehrlich ascites tumor cells. Proc Natl Acad Sci U S A. 1980 May;77(5):2487–2491. doi: 10.1073/pnas.77.5.2487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hoult D. I., Busby S. J., Gadian D. G., Radda G. K., Richards R. E., Seeley P. J. Observation of tissue metabolites using 31P nuclear magnetic resonance. Nature. 1974 Nov 22;252(5481):285–287. doi: 10.1038/252285a0. [DOI] [PubMed] [Google Scholar]
  9. Koeze T. H. Applications of nuclear magnetic resonance in medicine. Br J Hosp Med. 1982 Apr;27(4):402-4, 407. [PubMed] [Google Scholar]
  10. Lantos P. L., Roscoe J. P., Skidmore C. J. Studies of the morphology and tumorigenicity of experimental brain tumours in tissue culture. Br J Exp Pathol. 1976 Feb;57(1):95–104. [PMC free article] [PubMed] [Google Scholar]
  11. Lowry O. H., Berger S. J., Chi M. M., Carter J. G., Blackshaw A., Outlaw W. Diversity of metabolic patterns in human brain tumors--I. High energy phosphate compounds and basic composition. J Neurochem. 1977 Dec;29(6):959–977. doi: 10.1111/j.1471-4159.1977.tb06500.x. [DOI] [PubMed] [Google Scholar]
  12. Navon G., Ogawa S., Shulman R. G., Yamane T. 31P nuclear magnetic resonance studies of Ehrlich ascites tumor cells. Proc Natl Acad Sci U S A. 1977 Jan;74(1):87–91. doi: 10.1073/pnas.74.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Purich D. L., Fromm H. J. Additional factors influencing enzyme responses to the adenylate energy charge. J Biol Chem. 1973 Jan 25;248(2):461–466. [PubMed] [Google Scholar]
  14. Racker E. Why do tumor cells have a high aerobic glycolysis? J Cell Physiol. 1976 Dec;89(4):697–700. doi: 10.1002/jcp.1040890429. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES