Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1984 Apr;49(4):503–512. doi: 10.1038/bjc.1984.78

Abdominal Burkitt-type lymphomas in Algeria.

Y Ladjadj, T Philip, G M Lenoir, F Z Tazerout, K Bendisari, R Boukheloua, P Biron, M Brunat-Mentigny, M Aboulola
PMCID: PMC1976758  PMID: 6324843

Abstract

In a previous retrospective analysis from the principal paediatric centres of Algeria, Burkitt-type lymphomas (BL) were shown to account for around 46.5% of the total childhood non-Hodgkin's malignant lymphomas in that country. In the present study, a series of 49 abdominal BL from the Paediatric Clinic of Surgery, Mustapha Hospital, Algiers, has been studied. The age distribution shows a peak between 4 and 5 years of age, and the sex ratio is (M:F) 2.26:1. The disease is characterized by a rapid evolution in the absence of therapy. The major problem is an explosive form of the disease, which at present seems difficult to control in this country. Fifteen of the 49 patients (30.6%) died before completion of the first course of chemotherapy; however, complete remission (CR) was obtained for 30 patients (61%). Overall survival was 42.85% (21/49), whereas survival of patients who reached CR is 70% (21/30). When CR was obtained, deaths were related to cerebrospinal fluid involvement, local recurrence, secondary bone marrow involvement or therapeutic accidents. All patients alive with no evidence of disease (NED) 8-months after CR can be considered definitively cured. Epstein-Barr virus (EBV) serology performed on 31 BL patients and on a control group of 25 children with other malignant tumours showed that most Algerian BL have elevated EBV titres. A search for viral markers within malignant cells in 17 patients indicated that 88% (15/17) of the BL cases were EBV-associated. Analysis of the immunological and cytogenetic data showed that, as in the rest of the world, these BL cases involve proliferation of B-cell-type lymphocytes, with characteristic cytogenetic translocations involving chromosome 8. This report represents the most detailed description so far of BL from an area in non-equatorial Africa and the first report of a large series from North Africa.

Full text

PDF
503

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aghai E., Hulu N., Virag I., Kende G., Ramot B. Childhood non-Hodgkin's lymphoma--a study of 17 cases in Israel. Cancer. 1974 May;33(5):1411–1416. doi: 10.1002/1097-0142(197405)33:5<1411::aid-cncr2820330527>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  2. BURKITT D. A children's cancer dependent on climatic factors. Nature. 1962 Apr 21;194:232–234. doi: 10.1038/194232a0. [DOI] [PubMed] [Google Scholar]
  3. BURKITT D. A sarcoma involving the jaws in African children. Br J Surg. 1958 Nov;46(197):218–223. doi: 10.1002/bjs.18004619704. [DOI] [PubMed] [Google Scholar]
  4. Berger R., Bernheim A., Weh H. J., Flandrin G., Daniel M. T., Brouet J. C., Colbert N. A new translocation in Burkitt's tumor cells. Hum Genet. 1979;53(1):111–112. doi: 10.1007/BF00289460. [DOI] [PubMed] [Google Scholar]
  5. Bernheim A., Berger R., Lenoir G. Cytogenetic studies on African Burkitt's lymphoma cell lines: t(8;14), t(2;8) and t(8;22) translocations. Cancer Genet Cytogenet. 1981 Jun;3(4):307–315. doi: 10.1016/0165-4608(81)90039-x. [DOI] [PubMed] [Google Scholar]
  6. Buchner A., Temkin D., David R. Burkitt's lymphoma in Israel. Refuat Hapeh Vehashinayim. 1978 Jul;27(3):5-7, 5-7. [PubMed] [Google Scholar]
  7. Cammoun M., Tabbane F., Mourali N., Gherab A. La tumeur de Burkitt en Tunisie. A propos d'une observation. Arch Anat Pathol (Paris) 1972 Jun;20(2):135–139. [PubMed] [Google Scholar]
  8. Cehreli C., Tosun N. Burkitt's lymphoma cell leukemia in a Turish boy. Cancer. 1975 Oct;36(4):1444–1449. doi: 10.1002/1097-0142(197510)36:4<1444::aid-cncr2820360436>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  9. DORFMAN R. F. CHILDHOOD LYMPHOSARCOMA IN ST. LOUIS, MISSOURI, CLINICALLY AND HISTOLOGICALLY RESEMBLING BURKITT'S TUMOR. Cancer. 1965 Apr;18:418–430. doi: 10.1002/1097-0142(196504)18:4<418::aid-cncr2820180404>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  10. EPSTEIN M. A., ACHONG B. G., BARR Y. M. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet. 1964 Mar 28;1(7335):702–703. doi: 10.1016/s0140-6736(64)91524-7. [DOI] [PubMed] [Google Scholar]
  11. Gerard-Marchant R., Bayle C., Caillou B. Histocytologie des lymphomes malins non Hodgkiniens de l'enfant. Etude de 161 cas typés selon la classification de Kiel. Ann Pathol. 1982;2(2):107–116. [PubMed] [Google Scholar]
  12. Geser A., Lenoir G. M., Anvret M., Bornkamm G., Klein G., Williams E. H., Wright D. H., De-The G. Epstein-Barr virus markers in a series of Burkitt's lymphomas from the West Nile District, Uganda. Eur J Cancer Clin Oncol. 1983 Oct;19(10):1393–1404. doi: 10.1016/0277-5379(93)90009-t. [DOI] [PubMed] [Google Scholar]
  13. Goldblum N., Ben-Bassat H., Mitrani S., Andersson-Anvret M., Goldblum T., Aghai E., Ramot B., Klein G. A case of an Epstein--Barr virus (EBV) genome-carrying lymphoma in an Israeli Arab child. Eur J Cancer. 1977 Jul;13(7):693–698. doi: 10.1016/0014-2964(77)90055-x. [DOI] [PubMed] [Google Scholar]
  14. Gotleib-Stematsky T., Ramot B., Vonsover B., Aghai E., Kende G., Ninio M., Modan M. Antibodies to Epstein-Barr viral capsid and early antigens associated with Burkitt's lymphoma and lymphoblastic lymphosarcoma in Israel. J Natl Cancer Inst. 1976 Apr;56(4):721–723. doi: 10.1093/jnci/56.4.721. [DOI] [PubMed] [Google Scholar]
  15. Hulu N., Ramot B., Sheehan W. Childhood abdominal lymphoma in Israel. Isr J Med Sci. 1970 Mar-Apr;6(2):246–252. [PubMed] [Google Scholar]
  16. Kalbian V. A case of Burkitt's lymphoma in an Arab child from Jordan. Int J Cancer. 1967 Nov 15;2(6):603–603. doi: 10.1002/ijc.2910020616. [DOI] [PubMed] [Google Scholar]
  17. Lenoir G., Philip T., Bornkamm G. W., Gillet P., Bryon P. A., Bouvier R., Dodat H., Doré J. F., Brunat-Mentigny M., Hermier M. Lymphome de Burkitt associé au virus Epstein-Barr chez un enfant français. Nouv Presse Med. 1979 Dec 17;8(49):4031–4033. [PubMed] [Google Scholar]
  18. Levine P. H., Kamaraju L. S., Connelly R. R., Berard C. W., Dorfman R. F., Magrath I., Easton J. M. The American Burkitt's Lymphoma Registry: eight years' experience. Cancer. 1982 Mar 1;49(5):1016–1022. doi: 10.1002/1097-0142(19820301)49:5<1016::aid-cncr2820490527>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  19. Manolov G., Manolova Y. Marker band in one chromosome 14 from Burkitt lymphomas. Nature. 1972 May 5;237(5349):33–34. doi: 10.1038/237033a0. [DOI] [PubMed] [Google Scholar]
  20. Mark-Vendel E., Philip T., Ladjaj Y., Aboulola M., Lenoir G. M. Chromosomal translocations in Algerian Burkitt's lymphoma. Lancet. 1983 Oct 1;2(8353):788–788. doi: 10.1016/s0140-6736(83)92315-2. [DOI] [PubMed] [Google Scholar]
  21. Murphy S. B. Prognostic features and obstacles to cure of childhood non-Hodgkin's lymphoma. Semin Oncol. 1977 Sep;4(3):265–271. [PubMed] [Google Scholar]
  22. Olweny C. L., Katongole-Mbidde E., Otim D., Lwanga S. K., Magrath I. T., Ziegler J. L. Long-term experience with Burkitt's lymphoma in Uganda. Int J Cancer. 1980 Sep 15;26(3):261–266. doi: 10.1002/ijc.2910260302. [DOI] [PubMed] [Google Scholar]
  23. Patte C., Rodary C., Sarrazin D., Bernard A., Lemerle J. Résultats du traitement de 178 lymphomes malins non hodgkiniens de l'enfant de 1973 à 1978. Arch Fr Pediatr. 1981 May;38(5):321–327. [PubMed] [Google Scholar]
  24. Philip T., Bryon P. A., Philippe N., Souillet G., Freycon F., Gérard-Marchant R., Brunat-Mentigny M. Individualisation anatomo-clinique du lymphome de Burkitt en France. A propos de 51 cas personnels. Pediatrie. 1980;35(8):677–691. [PubMed] [Google Scholar]
  25. Philip T., Lenoir G. M., Brunat-Mentigny M., Bertrand S., Gentilhomme O., Souillet G., Philippe N. Individualisation pathogénique du lymphome de Burkitt en France. Pediatrie. 1980;35(8):659–676. [PubMed] [Google Scholar]
  26. Philip T., Lenoir G. M., Bryon P. A., Gerard-Marchant R., Souillet G., Philippe N., Freycon F., Brunat-Mentigny M. Burkitt-type lymphoma in France among non-Hodgkin malignant lymphomas in Caucasian children. Br J Cancer. 1982 May;45(5):670–678. doi: 10.1038/bjc.1982.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Philip T., Lenoir G. M., Fraisse J., Philip I., Bertoglio J., Ladjaj S., Bertrand S., Brunat-Mentigny M. EBV-positive Burkitt's lymphoma from Algeria, with a three-way rearrangement involving chromosomes 2, 8 and 9. Int J Cancer. 1981 Oct 15;28(4):417–420. doi: 10.1002/ijc.2910280404. [DOI] [PubMed] [Google Scholar]
  28. Prokocimer M., Matzner Y., Ben-Bassat H., Polliack A. Burkitt's lymphoma presenting as acute leukemia (Burkitt's lymphoma cell leukemia): report of two cases in Israel. Cancer. 1980 Jun 1;45(11):2884–2889. doi: 10.1002/1097-0142(19800601)45:11<2884::aid-cncr2820451128>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  29. Say B., Hosal N., Tinaztepe B. A case of lymphosarcoma, resembling Burkitt's tumor, in a Turkish child. Int J Cancer. 1967 Nov 15;2(6):610–610. doi: 10.1002/ijc.2910020620. [DOI] [PubMed] [Google Scholar]
  30. Selzer G., Sacks M., Sherman G., Naggan L. Primary malignant lymphoma of the small intestine in Israel. Changing incidence with time. Isr J Med Sci. 1979 Apr;15(4):390–396. [PubMed] [Google Scholar]
  31. Selzer G., Sherman G., Callihan T. R., Schwartz Y. Primary small intestinal lymphomas and alpha-heavy-chain disease. A study of 43 cases from a pathology department in Israel. Isr J Med Sci. 1979 Feb;15(2):111–123. [PubMed] [Google Scholar]
  32. Tinaztepe B., Işik T., Tinaztepe K. Burkitt's lymphoma. (Studies of 20 cases seen in Hacettepe Children's Hospital compared with Burkitt's tumor in African children. Turk J Pediatr. 1973 Jul;15(3):129–142. [PubMed] [Google Scholar]
  33. Ziegler J. L. Treatment results of 54 American patients with Burkitt's lymphoma are similar to the African experience. N Engl J Med. 1977 Jul 14;297(2):75–80. doi: 10.1056/NEJM197707142970202. [DOI] [PubMed] [Google Scholar]
  34. de-Thé G., Geser A., Day N. E., Tukei P. M., Williams E. H., Beri D. P., Smith P. G., Dean A. G., Bronkamm G. W., Feorino P. Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study. Nature. 1978 Aug 24;274(5673):756–761. doi: 10.1038/274756a0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES