Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1984 Aug;50(2):215–221. doi: 10.1038/bjc.1984.165

Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.

H Métivier, J Wahrendorf, R Masse
PMCID: PMC1976869  PMID: 6087866

Abstract

This study describes the effect of intratracheal instillations (2 X 5 mg) of benzo(a)pyrene (B(a)P) on lung carcinogenesis in rats which had previously inhaled different levels of 239 plutonium oxide (220, 630, 6300 Bq, initial lung burden). Survival decreased with increasing PuO2 exposure and additional B(a)P exposure. The incidence of malignant lung tumours, adjusted for differences in survival, increased in a dose-related fashion with PuO2 dose and was elevated in the presence of additional B(a)P exposure. A multiplicative relative risk model was found to describe reasonably well the observed joint effect. The practical implications of these findings are discussed.

Full text

PDF
215

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blot W. J., Day N. E. Synergism and interaction: are they equivalent? Am J Epidemiol. 1979 Jul;110(1):99–100. doi: 10.1093/oxfordjournals.aje.a112793. [DOI] [PubMed] [Google Scholar]
  2. Chmelevsky D., Kellerer A. M., Lafuma J., Chameaud J. Maximum likelihood estimation of the prevalence of nonlethal neoplasms--an application to radon-daughter inhalation studies. Radiat Res. 1982 Sep;91(3):589–614. [PubMed] [Google Scholar]
  3. Farber E. Chemical carcinogenesis: a biologic perspective. Am J Pathol. 1982 Feb;106(2):271–296. [PMC free article] [PubMed] [Google Scholar]
  4. Gart J. J., Chu K. C., Tarone R. E. Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J Natl Cancer Inst. 1979 Apr;62(4):957–974. [PubMed] [Google Scholar]
  5. McClellan R. O. Progress in studies with transuranic elements at the Lovelace Foundation. Health Phys. 1972 Jun;22(6):815–822. doi: 10.1097/00004032-197206000-00043. [DOI] [PubMed] [Google Scholar]
  6. Peto R. Editorial: Guidelines on the analysis of tumour rates and death rates in experimental animals. Br J Cancer. 1974 Feb;29(2):101–105. doi: 10.1038/bjc.1974.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Saffiotti U., Montesano R., Sellakumar A. R., Cefis F., Kaufman D. G. Respiratory tract carcinogenesis in hamsters induced by different numbers of administrations of benzo(a)pyrene and ferric oxide. Cancer Res. 1972 May;32(5):1073–1081. [PubMed] [Google Scholar]
  8. Saffiotti U., Montesano R., Sellakumar A. R., Kaufman D. G. Respiratory tract carcinogenesis induced in hamsters by different dose levels of benzo-(a)pyrene and ferric oxide. J Natl Cancer Inst. 1972 Oct;49(4):1199–1204. [PubMed] [Google Scholar]
  9. Sanders C. L., Dagle G. E., Cannon W. C., Craig D. K., Powers G. J., Meier D. M. Inhalation carcinogenesis of high-fired 239PuO2 in rats. Radiat Res. 1976 Nov;68(2):349–360. [PubMed] [Google Scholar]
  10. Sanders C. L., Mahaffey J. A. Carcinogenicity of inhaled air-oxidized 239PuO2 in rats. Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Jan;35(1):95–98. doi: 10.1080/09553007914550091. [DOI] [PubMed] [Google Scholar]
  11. Saracci R. Asbestos and lung cancer: an analysis of the epidemiological evidence on the asbestos-smoking interaction. Int J Cancer. 1977 Sep 15;20(3):323–331. doi: 10.1002/ijc.2910200302. [DOI] [PubMed] [Google Scholar]
  12. TEMPLE L. A., MARKS S., BAIR W. J. Tumours in mice after pulmonary deposition of radioactive particles. Int J Radiat Biol Relat Stud Phys Chem Med. 1960 Apr;2:143–156. doi: 10.1080/09553006014550161. [DOI] [PubMed] [Google Scholar]
  13. Whittemore A. S., McMillan A. Lung cancer mortality among U.S. uranium miners: a reappraisal. J Natl Cancer Inst. 1983 Sep;71(3):489–499. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES