Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1985 Mar;51(3):407–413. doi: 10.1038/bjc.1985.55

Tumour cords in 52 human bronchial and cervical squamous cell carcinomas: inferences for their cellular kinetics and radiobiology.

J V Moore, P S Hasleton, C H Buckley
PMCID: PMC1976955  PMID: 3970817

Abstract

Tumour cords have been measured in 33 cases of squamous cell carcinoma (SCC) of the bronchus and 19 cases of SCC of the uterine cervix. The overall mean cord radius for SCC in both sites was 104 microns, similar to the overall mean for various tumours in rodents. For tumour cells adjacent to blood vessels in cords of SCC, the mean Mitotic Index was 2.1% and from this value a rapid potential doubling time could be inferred (approximately 31 to 66 h). The proportion of dead cells within cords of cervical SCC was higher than in animal tumours. Using measured values for cord radius and published equations that describe the diffusion and consumption of oxygen in metabolising tissue, an attempt was made to calculate the oxygen partial pressure in vessels of cords of these SCC.

Full text

PDF
407

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALPER T., HOWARD-FLANDERS P. Role of oxygen in modifying the radiosensitivity of E. coli B. Nature. 1956 Nov 3;178(4540):978–979. doi: 10.1038/178978a0. [DOI] [PubMed] [Google Scholar]
  2. Brammer I., Zywietz F., Jung H. Changes of histological and proliferative indices in the Walker carcinoma with tumour size and distance from blood vessel. Eur J Cancer. 1979 Nov;15(11):1329–1336. doi: 10.1016/0014-2964(79)90109-9. [DOI] [PubMed] [Google Scholar]
  3. GRAY L. H., CONGER A. D., EBERT M., HORNSEY S., SCOTT O. C. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol. 1953 Dec;26(312):638–648. doi: 10.1259/0007-1285-26-312-638. [DOI] [PubMed] [Google Scholar]
  4. Gosalvez M., Thurman R. G., Chance B., Reinhold H. Regional variation in the oxygenation of mouse mammary tumours in vivo demonstrated by fluorescence of pyridine nucleotide. Br J Radiol. 1972 Jul;45(535):510–514. doi: 10.1259/0007-1285-45-535-510. [DOI] [PubMed] [Google Scholar]
  5. Hirst D. G., Denekamp J., Hobson B. Proliferation kinetics of endothelial and tumour cells in three mouse mammary carcinomas. Cell Tissue Kinet. 1982 May;15(3):251–261. doi: 10.1111/j.1365-2184.1982.tb01044.x. [DOI] [PubMed] [Google Scholar]
  6. Hirst D. G., Denekamp J. Tumour cell proliferation in relation to the vasculature. Cell Tissue Kinet. 1979 Jan;12(1):31–42. doi: 10.1111/j.1365-2184.1979.tb00111.x. [DOI] [PubMed] [Google Scholar]
  7. Jones B., Camplejohn R. S. Stathmokinetic measurement of tumour cell proliferation in relation to vascular proximity. Cell Tissue Kinet. 1983 Jul;16(4):351–355. [PubMed] [Google Scholar]
  8. Kolstad P. Intercapillary distance, oxygen tension and local recurrence in cervix cancer. Scand J Clin Lab Invest Suppl. 1968;106:145–157. [PubMed] [Google Scholar]
  9. Malaise E. P., Chavaudra N., Tubiana M. The relationship between growth rate, labelling index and histological type of human solid tumours. Eur J Cancer. 1973 Apr;9(4):305–312. doi: 10.1016/0014-2964(73)90099-6. [DOI] [PubMed] [Google Scholar]
  10. Moore J. V., Hopkins H. A., Looney W. B. Dynamic histology of a rat hepatoma and the response to 5-fluorouracil. Cell Tissue Kinet. 1980 Jan;13(1):53–63. doi: 10.1111/j.1365-2184.1980.tb00449.x. [DOI] [PubMed] [Google Scholar]
  11. Moore J. V., Hopkins H. A., Looney W. B. Response of cell populations in tumor cords to a single dose of cyclophosphamide or radiation. Eur J Cancer Clin Oncol. 1983 Jan;19(1):73–79. doi: 10.1016/0277-5379(83)90401-7. [DOI] [PubMed] [Google Scholar]
  12. Moore J. V., Hopkins H. A., Looney W. B. Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status. Radiat Environ Biophys. 1984;23(3):213–222. doi: 10.1007/BF01213223. [DOI] [PubMed] [Google Scholar]
  13. THOMLINSON R. H. An experimental method for comparing treatments of intact malignant tumours in animals and its application to the use of oxygen in radiotherapy. Br J Cancer. 1960 Sep;14:555–576. doi: 10.1038/bjc.1960.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. THOMLINSON R. H., GRAY L. H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955 Dec;9(4):539–549. doi: 10.1038/bjc.1955.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tannock I. F. Oxygen diffusion and the distribution of cellular radiosensitivity in tumours. Br J Radiol. 1972 Jul;45(535):515–524. doi: 10.1259/0007-1285-45-535-515. [DOI] [PubMed] [Google Scholar]
  16. Tannock I. F., Steel G. G. Tumor growth and cell kinetics in chronically hypoxic animals. J Natl Cancer Inst. 1970 Jul;45(1):123–133. [PubMed] [Google Scholar]
  17. Tannock I. F. The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br J Cancer. 1968 Jun;22(2):258–273. doi: 10.1038/bjc.1968.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Tannock I., Howes A. The response of viable tumor cords to a single dose of radiation. Radiat Res. 1973 Sep;55(3):477–486. [PubMed] [Google Scholar]
  19. Yamaura H., Matsuzawa T. Tumor regrowth after irradiation; an experimental approach. Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Mar;35(3):201–219. doi: 10.1080/09553007914550241. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES