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. 1985 Feb;51(2):229–235. doi: 10.1038/bjc.1985.33

Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: evidence that a side-chain label is bound as efficiently as a ring label.

J A Raleigh, A J Franko, C J Koch, J L Born
PMCID: PMC1977042  PMID: 3966980

Abstract

The binding of ring-labelled and side-chain labelled misonidazole to hypoxic cells in monolayer and spheroid cultures of mammalian cells has been compared. The kinetics and patterns of binding for the two labelled compounds are indistinguishable. This finding has implications for the mechanism of binding and for the design of misonidazole analogues which might be used to identify hypoxic zones in tumours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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