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. 1985 May;51(5):675–680. doi: 10.1038/bjc.1985.102

Human tumour cell lines established in vitro from tumours after long-term passage as nude mouse xenografts. Comparative fingerprinting of their concanavalin-A acceptor glycoproteins.

J Walton, D Winterbourne, A Fiennes, P Harris, J Hermon-Taylor, A Grant
PMCID: PMC1977045  PMID: 3994910

Abstract

Two human colon cancer xenografts (EC and AC) were established in tissue culture only after long-term passage in nude mice. Earlier attempts to establish cell lines were unsuccessful. The epithelioid cells retain their tumourigenicity after in vitro growth, giving rise to tumours with a take rate of 60-80%. After reimplantation, the xenografts retain a similar morphology to that of the original human tumours. Both cell lines show human karyology. Comparative mapping of Concanavalin-A acceptor glycoproteins provides a fingerprint characteristic of each cell line. These glycoprotein patterns are similar to those shown by HT-29, an established colon cancer cell line.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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