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. 1985 Jul;52(1):59–64. doi: 10.1038/bjc.1985.149

Detection of placental-type alkaline phosphatase in ovarian cancer.

I W McDicken, P J McLaughlin, P M Tromans, D M Luesley, P M Johnson
PMCID: PMC1977171  PMID: 3893506

Abstract

A monoclonal antibody, H317, has been used for the sensitive and specific detection of placental-type alkaline phosphatase (PLAP) in sera, solubilized tissue extracts and fixed tumour tissue sections from patients representing a variety of ovarian tumours. PLAP was detected in over 30% of these sera and in most solubilized tumour tissue extracts. There was no association between circulating PLAP levels and either tissue extract levels or immunohistological staining of ovarian tumour tissue sections with H317. Nevertheless, immunohistology demonstrated the heterogeneity of cellular localization of PLAP within different tumours, and can often be of value in localizing tumour tissue.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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