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. 1985 Sep;52(3):333–338. doi: 10.1038/bjc.1985.198

Evaluation of a radioimmunoassay for neuron specific enolase in small cell lung cancer.

E H Cooper, T A Splinter, D A Brown, M F Muers, M D Peake, S L Pearson
PMCID: PMC1977198  PMID: 2994704

Abstract

A radioimmunoassay for neuron specific enolase (NSE), a marker of neuroendocrine differentiation, has been evaluated in small cell lung cancer (SCLC). In untreated patients 25/38 (68%) with localized SCLC had raised blood levels of NSE (greater than 13 ng ml-1), in extensive disease 34/39 (87%) patients had raised NSE levels. In patients with non-small cell lung cancer (NSCLC) the serum levels were raised in 16/94 (17%). In extensive tumours of non-pulmonary origin NSE levels were increased in 24/116 (20%) patients. Longitudinal studies indicated a good correlation between the response to chemotherapy and fall of NSE levels. Tumour progression was accompanied by a rising NSE in 25/29 patients, with doubling times of 7-90 days. In patients with progression with a normal NSE the recurrence was a NSCLC. Cerebral metastases occurring as the only recurrence during clinical complete remission were not accompanied by a rise of NSE. Serum NSE levels provides a valuable monitor for SCLC during and after chemotherapy.

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Selected References

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  1. Akoun G. M., Scarna H. M., Milleron B. J., Bénichou M. P., Herman D. P. Serum neuron-specific enolase. A marker for disease extent and response to therapy for small-cell lung cancer. Chest. 1985 Jan;87(1):39–43. doi: 10.1378/chest.87.1.39. [DOI] [PubMed] [Google Scholar]
  2. Ariyoshi Y., Kato K., Ishiguro Y., Ota K., Sato T., Suchi T. Evaluation of serum neuron-specific enolase as a tumor marker for carcinoma of the lung. Gan. 1983 Apr;74(2):219–225. [PubMed] [Google Scholar]
  3. Ariyoshi Y. [Evaluation of neuron-specific enolase as a new tumor marker for carcinoma of the lung]. Gan No Rinsho. 1984 May;30(6 Suppl):569–573. [PubMed] [Google Scholar]
  4. Carney D. N., Marangos P. J., Ihde D. C., Bunn P. A., Jr, Cohen M. H., Minna J. D., Gazdar A. F. Serum neuron-specific enolase: a marker for disease extent and response to therapy of small-cell lung cancer. Lancet. 1982 Mar 13;1(8272):583–585. doi: 10.1016/s0140-6736(82)91748-2. [DOI] [PubMed] [Google Scholar]
  5. Esscher T., Steinholtz L., Bergh J., Nöu E., Nilsson K., Påhlman S. Neurone specific enolase: a useful diagnostic serum marker for small cell carcinoma of the lung. Thorax. 1985 Feb;40(2):85–90. doi: 10.1136/thx.40.2.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gerbitz K. D., Summer J., Thallemer J. Brain-specific proteins: solid-phase immunobioluminescence assay for neuron-specific enolase in human plasma. Clin Chem. 1984 Mar;30(3):382–386. [PubMed] [Google Scholar]
  7. Johnson D. H., Marangos P. J., Forbes J. T., Hainsworth J. D., Van Welch R., Hande K. R., Greco F. A. Potential utility of serum neuron-specific enolase levels in small cell carcinoma of the lung. Cancer Res. 1984 Nov;44(11):5409–5414. [PubMed] [Google Scholar]
  8. Kato K., Asai R., Shimizu A., Suzuki F., Ariyoshi Y. Immunoassay of three enolase isozymes in human serum and in blood cells. Clin Chim Acta. 1983 Feb 7;127(3):353–363. doi: 10.1016/0009-8981(83)90162-6. [DOI] [PubMed] [Google Scholar]
  9. Lloyd R. V., Mervak T., Schmidt K., Warner T. F., Wilson B. S. Immunohistochemical detection of chromogranin and neuron-specific enolase in pancreatic endocrine neoplasms. Am J Surg Pathol. 1984 Aug;8(8):607–614. doi: 10.1097/00000478-198408000-00004. [DOI] [PubMed] [Google Scholar]
  10. Lloyd R. V., Sisson J. C., Marangos P. J. Calcitonin, carcinoembryonic antigen and neuron-specific enolase in medullary thyroid carcinoma. Cancer. 1983 Jun 15;51(12):2234–2239. doi: 10.1002/1097-0142(19830615)51:12<2234::aid-cncr2820511214>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  11. Marangos P. J., Gazdar A. F., Carney D. N. Neuron specific enolase in human small cell carcinoma cultures. Cancer Lett. 1982 Jan;15(1):67–71. doi: 10.1016/0304-3835(82)90077-5. [DOI] [PubMed] [Google Scholar]
  12. Marangos P. J., Schmechel D., Parma A. M., Clark R. L., Goodwin F. K. Measurement of neuron-specific (NSE) and non-neuronal (NNE) isoenzymes of enolase in rat, monkey and human nervous tissue. J Neurochem. 1979 Jul;33(1):319–329. doi: 10.1111/j.1471-4159.1979.tb11735.x. [DOI] [PubMed] [Google Scholar]
  13. Odelstad L., Påhlman S., Läckgren G., Larsson E., Grotte G., Nilsson K. Neuron specific enolase: a marker for differential diagnosis of neuroblastoma and Wilms' tumor. J Pediatr Surg. 1982 Aug;17(4):381–385. doi: 10.1016/s0022-3468(82)80494-6. [DOI] [PubMed] [Google Scholar]
  14. Prinz R. A., Bermes E. W., Jr, Kimmel J. R., Marangos P. J. Serum markers for pancreatic islet cell and intestinal carcinoid tumors: a comparison of neuron-specific enolase, beta-human chorionic gonadotropin and pancreatic polypeptide. Surgery. 1983 Dec;94(6):1019–1023. [PubMed] [Google Scholar]
  15. Påhlman S., Esscher T., Bergh J., Steinholtz L., Nöu E., Nilsson K. Neuron-specific enolase as a marker for neuroblastoma and small-cell carcinoma of the lung. Tumour Biol. 1984;5(2):119–126. [PubMed] [Google Scholar]
  16. Royds J. A., Lilleyman J. S., Timperley W. R., Taylor C. B. Cerebrospinal fluid enolase isoenzymes and neurotoxicity in early treatment of lymphoblastic leukaemia. Arch Dis Child. 1984 Mar;59(3):266–269. doi: 10.1136/adc.59.3.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sheppard M. N., Corrin B., Bennett M. H., Marangos P. J., Bloom S. R., Polak J. M. Immunocytochemical localization of neuron specific enolase in small cell carcinomas and carcinoid tumours of the lung. Histopathology. 1984 Mar;8(2):171–181. doi: 10.1111/j.1365-2559.1984.tb02334.x. [DOI] [PubMed] [Google Scholar]
  18. Springall D. R., Lackie P., Levene M. M., Marangos P. J., Polak J. M. Immunostaining of neuron-specific enolase is a valuable aid to the cytological diagnosis of neuroendocrine tumours of the lung. J Pathol. 1984 Aug;143(4):259–265. doi: 10.1002/path.1711430405. [DOI] [PubMed] [Google Scholar]
  19. Thompson R. J., Day I. N. Measuring serum neurone-specific enolase. Lancet. 1982 May 15;1(8281):1126–1126. doi: 10.1016/s0140-6736(82)92310-8. [DOI] [PubMed] [Google Scholar]
  20. Tsokos M., Linnoila R. I., Chandra R. S., Triche T. J. Neuron-specific enolase in the diagnosis of neuroblastoma and other small, round-cell tumors in children. Hum Pathol. 1984 Jun;15(6):575–584. doi: 10.1016/s0046-8177(84)80012-x. [DOI] [PubMed] [Google Scholar]
  21. Wevers R. A., Jacobs A. A., Hommes O. R. A bioluminescent assay for enolase (EC 4.2.1.11) activity in human serum and cerebrospinal fluid. Clin Chim Acta. 1983 Dec 15;135(2):159–168. doi: 10.1016/0009-8981(83)90131-6. [DOI] [PubMed] [Google Scholar]
  22. Zeltzer P. M., Marangos P. J., Parma A. M., Sather H., Dalton A., Hammond D., Siegel S. E., Seeger R. C. Raised neuron-specific enolase in serum of children with metastatic neuroblastoma. A report from the Children's Cancer Study Group. Lancet. 1983 Aug 13;2(8346):361–363. doi: 10.1016/s0140-6736(83)90342-2. [DOI] [PubMed] [Google Scholar]

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