Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1992 May;65(5):783–785. doi: 10.1038/bjc.1992.167

Carcinoma of the cervix uteri: an assessment of the relationship of tumour proliferation to prognosis.

D J Cole 1, D C Brown 1, E Crossley 1, C J Alcock 1, K C Gatter 1
PMCID: PMC1977376  PMID: 1586610

Abstract

The aim of this study was to ascertain whether assessing the growth fraction of cervical carcinoma of 28 patients, using antibody Ki-67, would be of value in clinical practice. The results showed no relationship between growth fraction and age, clinical stage, lymph node involvement or short term (3-5 years) survival.

Full text

PDF
783

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alcock C. J., Toplis P. J. The influence of pelvic lymph node disease on survival for stage I and II carcinoma of the cervix. Clin Radiol. 1987 Jan;38(1):13–16. doi: 10.1016/s0009-9260(87)80386-0. [DOI] [PubMed] [Google Scholar]
  2. Bobrow L. G., Makin C. A., Law S., Bodmer W. F. Expression of low molecular weight cytokeratin proteins in cervical neoplasia. J Pathol. 1986 Feb;148(2):135–140. doi: 10.1002/path.1711480203. [DOI] [PubMed] [Google Scholar]
  3. Brown D. C., Cole D., Gatter K. C., Mason D. Y. Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67. Br J Cancer. 1988 Feb;57(2):178–181. doi: 10.1038/bjc.1988.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown D. C., Gatter K. C. Monoclonal antibody Ki-67: its use in histopathology. Histopathology. 1990 Dec;17(6):489–503. doi: 10.1111/j.1365-2559.1990.tb00788.x. [DOI] [PubMed] [Google Scholar]
  5. Cordell J. L., Falini B., Erber W. N., Ghosh A. K., Abdulaziz Z., MacDonald S., Pulford K. A., Stein H., Mason D. Y. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 1984 Feb;32(2):219–229. doi: 10.1177/32.2.6198355. [DOI] [PubMed] [Google Scholar]
  6. Crissman J. D., Makuch R., Budhraja M. Histopathologic grading of squamous cell carcinoma of the uterine cervix. An evaluation of 70 stage Ib patients. Cancer. 1985 Apr 1;55(7):1590–1596. doi: 10.1002/1097-0142(19850401)55:7<1590::aid-cncr2820550730>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  7. Fray R. E., Husain O. A., To A. C., Watts K. C., Lader S., Rogers G. T., Taylor-Papadimitriou J., Morris N. F. The value of immunohistochemical markers in the diagnosis of cervical neoplasia. Br J Obstet Gynaecol. 1984 Oct;91(10):1037–1041. doi: 10.1111/j.1471-0528.1984.tb03684.x. [DOI] [PubMed] [Google Scholar]
  8. Gatter K. C., Dunnill M. S., Gerdes J., Stein H., Mason D. Y. New approach to assessing lung tumours in man. J Clin Pathol. 1986 Jun;39(6):590–593. doi: 10.1136/jcp.39.6.590. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gerdes J., Dallenbach F., Lennert K., Lemke H., Stein H. Growth fractions in malignant non-Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki-67. Hematol Oncol. 1984 Oct-Dec;2(4):365–371. doi: 10.1002/hon.2900020406. [DOI] [PubMed] [Google Scholar]
  10. Gerdes J., Lelle R. J., Pickartz H., Heidenreich W., Schwarting R., Kurtsiefer L., Stauch G., Stein H. Growth fractions in breast cancers determined in situ with monoclonal antibody Ki-67. J Clin Pathol. 1986 Sep;39(9):977–980. doi: 10.1136/jcp.39.9.977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gerdes J., Lemke H., Baisch H., Wacker H. H., Schwab U., Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984 Oct;133(4):1710–1715. [PubMed] [Google Scholar]
  12. Gerdes J., Li L., Schlueter C., Duchrow M., Wohlenberg C., Gerlach C., Stahmer I., Kloth S., Brandt E., Flad H. D. Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol. 1991 Apr;138(4):867–873. [PMC free article] [PubMed] [Google Scholar]
  13. Goellner J. R. Carcinoma of the cervix. Clinicopathologic correlation of 196 cases. Am J Clin Pathol. 1976 Nov;66(5):775–785. doi: 10.1093/ajcp/66.5.775. [DOI] [PubMed] [Google Scholar]
  14. Hall P. A., Richards M. A., Gregory W. M., d'Ardenne A. J., Lister T. A., Stansfeld A. G. The prognostic value of Ki67 immunostaining in non-Hodgkin's lymphoma. J Pathol. 1988 Mar;154(3):223–235. doi: 10.1002/path.1711540305. [DOI] [PubMed] [Google Scholar]
  15. Hall S. W., Monaghan J. M. Invasive carcinoma of the cervix in younger women. Lancet. 1983 Sep 24;2(8352):731–731. doi: 10.1016/s0140-6736(83)92262-6. [DOI] [PubMed] [Google Scholar]
  16. Montana G. S., Fowler W. C., Jr, Varia M. A., Walton L. A., Kirsch M., Halle J. S., McCafferty B. B. Carcinoma of the cervix stage IB: results of treatment with radiation therapy. Int J Radiat Oncol Biol Phys. 1983 Jan;9(1):45–49. doi: 10.1016/0360-3016(83)90207-9. [DOI] [PubMed] [Google Scholar]
  17. Ng A. B., Atkin N. B. Histological cell type and DNA value in the prognosis of squamous cell cancer of uterine cervix. Br J Cancer. 1973 Oct;28(4):322–331. doi: 10.1038/bjc.1973.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Russell J. M., Blair V., Hunter R. D. Cervical carcinoma: prognosis in younger patients. Br Med J (Clin Res Ed) 1987 Aug 1;295(6593):300–303. doi: 10.1136/bmj.295.6593.300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Van Nagell J. R., Jr, Donaldson E. S., Wood E. G., Maruyama Y., Utley J. Small cell cancer of the uterine cervix. Cancer. 1977 Nov;40(5):2243–2249. doi: 10.1002/1097-0142(197711)40:5<2243::aid-cncr2820400534>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  20. Wells M., Brown L. J., Jackson P. Low molecular weight cytokeratin proteins in cervical neoplasia. J Pathol. 1986 Sep;150(1):69–71. doi: 10.1002/path.1711500112. [DOI] [PubMed] [Google Scholar]
  21. Wiernik G. The combination of radiotherapy and surgery in the treatment of carcinoma of the uterine cervix. Br J Radiol. 1986 Feb;59(698):97–105. doi: 10.1259/0007-1285-59-698-97. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES