Abstract
A nationwide mammographic screening for breast cancer was started in Finland in 1987. During the first 2 years of the organised screening programme, 126,000 women were invited. Most of them (103,000) belonged to the birth year cohort in the 50-59 years' age groups. Among the 112,000 screenees, 418 cancers (0.4%) were found. Specificity of the test was about 96%. The screening prevalence was 2.4 times the annual incidence and a minimum estimate for the detection rate among those invited was 1.6 times that among those not invited. These estimates indicate a relatively low test and programme sensitivity. The final effectiveness of a public health policy cannot be predicted on the basis of limited preventive trials, and there is need to evaluate also a public health policy by experimental means.
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- Andersson I., Aspegren K., Janzon L., Landberg T., Lindholm K., Linell F., Ljungberg O., Ranstam J., Sigfússon B. Mammographic screening and mortality from breast cancer: the Malmö mammographic screening trial. BMJ. 1988 Oct 15;297(6654):943–948. doi: 10.1136/bmj.297.6654.943. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Collette H. J., Day N. E., Rombach J. J., de Waard F. Evaluation of screening for breast cancer in a non-randomised study (the DOM project) by means of a case-control study. Lancet. 1984 Jun 2;1(8388):1224–1226. doi: 10.1016/s0140-6736(84)91704-5. [DOI] [PubMed] [Google Scholar]
- Hakama M., Chamberlain J., Day N. E., Miller A. B., Prorok P. C. Evaluation of screening programmes for gynaecological cancer. Br J Cancer. 1985 Oct;52(4):669–673. doi: 10.1038/bjc.1985.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kallioniemi O. P., Kärkkäinen A., Auvinen O., Mattila J., Koivula T., Hakama M. DNA flow cytometric analysis indicates that many breast cancers detected in the first round of mammographic screening have a low malignant potential. Int J Cancer. 1988 Nov 15;42(5):697–702. doi: 10.1002/ijc.2910420511. [DOI] [PubMed] [Google Scholar]
- Kallioniemi O. P., Kärkkäinen A., Mattila J., Auvinen O., Koivula T., Hakama M. Mammografiaseulonnassa todettavien rintasyöpien biologiset ominaisuudet--virtaussytometrinen tutkimus. Duodecim. 1989;105(18):1532–1538. [PubMed] [Google Scholar]
- Roberts M. M., Alexander F. E., Anderson T. J., Chetty U., Donnan P. T., Forrest P., Hepburn W., Huggins A., Kirkpatrick A. E., Lamb J. Edinburgh trial of screening for breast cancer: mortality at seven years. Lancet. 1990 Feb 3;335(8684):241–246. doi: 10.1016/0140-6736(90)90066-e. [DOI] [PubMed] [Google Scholar]
- Tabár L., Fagerberg C. J., Gad A., Baldetorp L., Holmberg L. H., Gröntoft O., Ljungquist U., Lundström B., Månson J. C., Eklund G. Reduction in mortality from breast cancer after mass screening with mammography. Randomised trial from the Breast Cancer Screening Working Group of the Swedish National Board of Health and Welfare. Lancet. 1985 Apr 13;1(8433):829–832. doi: 10.1016/s0140-6736(85)92204-4. [DOI] [PubMed] [Google Scholar]
- Verbeek A. L., Hendriks J. H., Holland R., Mravunac M., Sturmans F., Day N. E. Reduction of breast cancer mortality through mass screening with modern mammography. First results of the Nijmegen project, 1975-1981. Lancet. 1984 Jun 2;1(8388):1222–1224. doi: 10.1016/s0140-6736(84)91703-3. [DOI] [PubMed] [Google Scholar]
- Verweij J., Stoter G., Dodion P., Farinean M. Rapid alkalinisation for flavone acetic acid administration: a potentially hazardous procedure. Lancet. 1988 Feb 20;1(8582):411–412. doi: 10.1016/s0140-6736(88)91200-7. [DOI] [PubMed] [Google Scholar]