Abstract
A longitudinal study of iron status markers (haemoglobin (Hb), serum (S-) iron, S-transferrin, transferrin saturation, S-ferritin) was performed in 31 chemotherapy treated patients with small cell lung cancer. At discovery, eight patients were anaemic (Hb less than 121 g l-1). Hb, S-iron and transferrin saturation were lower (P less than 0.01), and S-ferritin higher (P less than 0.01) than in healthy subjects. Chemotherapy induced an immediate fall in Hb (P less than 0.003), increase in S-iron (P less than 0.003) and transferrin saturation (P less than 0.001). Later in the disease a fall in S-transferrin (P less than 0.006) and an increase in S-ferritin (P less than 0.02) occurred. Thirty patients died during the 2 years observation. S-ferritin at discovery was correlated to performance status score (r = 0.57, P = 0.01) and to survival (r = -0.63, P less than 0.0002). Patients with S-ferritin less than or equal to 400 micrograms l-1 (n = 13) had longer survival than those with S-ferritin greater than 400 micrograms l-1 (n = 18) (P = 0.004).
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cox R., Gyde O. H., Leyland M. J. Serum ferritin levels in small cell lung cancer. Eur J Cancer Clin Oncol. 1986 Jul;22(7):831–835. doi: 10.1016/0277-5379(86)90370-6. [DOI] [PubMed] [Google Scholar]
- Doll D. C., Weiss R. B. Chemotherapeutic agents and the erythron. Cancer Treat Rev. 1983 Sep;10(3):185–200. doi: 10.1016/0305-7372(83)90032-4. [DOI] [PubMed] [Google Scholar]
- Gropp C., Havemann K., Lehmann F. G. Carcinoembryonic antigen and ferritin in patients with lung cancer before and during therapy. Cancer. 1978 Dec;42(6):2802–2808. doi: 10.1002/1097-0142(197812)42:6<2802::aid-cncr2820420641>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
- Hazard J. T., Yokota M., Arosio P., Drysdale J. W. Immunologic differences in human isoferritins: implications for immunologic quantitation of serum ferritin. Blood. 1977 Jan;49(1):139–146. [PubMed] [Google Scholar]
- Hughes N. R. Serum transferrin and ceruloplasmin concentrations in patients with carcinoma, melanoma, sarcoma and cancers of haematopoietic tissues. Aust J Exp Biol Med Sci. 1972 Feb;50(1):97–107. doi: 10.1038/icb.1972.8. [DOI] [PubMed] [Google Scholar]
- Lipschitz D. A., Simon M. O., Lynch S. R., Dugard J., Bothwell T. H., Charlton R. W. Some factors affecting the release of iron from reticuloendothelial cells. Br J Haematol. 1971 Sep;21(3):289–303. doi: 10.1111/j.1365-2141.1971.tb03441.x. [DOI] [PubMed] [Google Scholar]
- Milman N., Pedersen N. S., Visfeldt J. Serum ferritin in healthy Danes: relation to marrow haemosiderin iron stores. Dan Med Bull. 1983 Mar;30(2):115–120. [PubMed] [Google Scholar]
- Osterlind K., Andersen P. K. Prognostic factors in small cell lung cancer: multivariate model based on 778 patients treated with chemotherapy with or without irradiation. Cancer Res. 1986 Aug;46(8):4189–4194. [PubMed] [Google Scholar]
- Osterlind K., Hansen M., Hirsch F. R., Dombernowsky P., Sörenson S., Pedersen A. G., Hansen H. H. Combination chemotherapy of limited-stage small-cell lung cancer. A controlled trial on 221 patients comparing two alternating regimens. Ann Oncol. 1991 Jan;2(1):41–46. doi: 10.1093/oxfordjournals.annonc.a057823. [DOI] [PubMed] [Google Scholar]
- Pollera C. F., Ameglio F., Reina S., Nardi M., Abbolito M. R., Parracino C. Changes in serum iron levels following very high-dose cisplatin. Cancer Chemother Pharmacol. 1987;19(3):257–260. doi: 10.1007/BF00252983. [DOI] [PubMed] [Google Scholar]
- Walters G. O., Miller F. M., Worwood M. Serum ferritin concentration and iron stores in normal subjects. J Clin Pathol. 1973 Oct;26(10):770–772. doi: 10.1136/jcp.26.10.770. [DOI] [PMC free article] [PubMed] [Google Scholar]