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British Journal of Cancer logoLink to British Journal of Cancer
editorial
. 1991 Aug;64(2):208–211. doi: 10.1038/bjc.1991.277

Membrane-interactive lipids as experimental anticancer drugs.

W E Berdel
PMCID: PMC1977494  PMID: 1892746

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andreesen R., Modolell M., Weltzien H. U., Eibl H., Common H. H., Löhr G. W., Munder P. G. Selective destruction of human leukemic cells by alkyl-lysophospholipids. Cancer Res. 1978 Nov;38(11 Pt 1):3894–3899. [PubMed] [Google Scholar]
  2. Andreesen R., Modolell M., Weltzien H. U., Munder P. G. Alkyl-lysophospholipid induced suppression of human lymphocyte response to mitogens and selective killing of lymphoblasts. Immunobiology. 1980 Jan;156(4-5):498–508. doi: 10.1016/S0171-2985(80)80083-0. [DOI] [PubMed] [Google Scholar]
  3. Andreesen R., Osterholz J., Luckenbach G. A., Costabel U., Schulz A., Speth V., Munder P. G., Löhr G. W. Tumor cytotoxicity of human macrophages after incubation with synthetic analogues of 2-lysophosphatidylcholine. J Natl Cancer Inst. 1984 Jan;72(1):53–59. doi: 10.1093/jnci/72.1.53. [DOI] [PubMed] [Google Scholar]
  4. Bazill G. W., Dexter T. M. Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells. Cancer Res. 1990 Dec 1;50(23):7505–7512. [PubMed] [Google Scholar]
  5. Berdel W. E., Bausert W. R., Weltzien H. U., Modolell M. L., Widmann K. H., Munder P. G. The influence of alkyl-lysophospholipids and lysophospholipid-activated macrophages on the development of metastasis of 3-Lewis lung carcinoma. Eur J Cancer. 1980 Sep;16(9):1199–1204. doi: 10.1016/0014-2964(80)90179-6. [DOI] [PubMed] [Google Scholar]
  6. Berdel W. E., Danhauser S., Hong C. I., Schick H. D., Reichert A., Busch R., Rastetter J., Vogler W. R. Influence of 1-beta-D-arabinofuranosylcytosine conjugates of lipids on the growth and metastasis of Lewis lung carcinoma. Cancer Res. 1988 Feb 15;48(4):826–829. [PubMed] [Google Scholar]
  7. Berdel W. E. Ether lipids and derivatives as investigational anticancer drugs. A brief review. Onkologie. 1990 Aug;13(4):245–250. doi: 10.1159/000216771. [DOI] [PubMed] [Google Scholar]
  8. Berdel W. E., Fromm M., Fink U., Pahlke W., Bicker U., Reichert A., Rastetter J. Cytotoxicity of thioether-lysophospholipids in leukemias and tumors of human origin. Cancer Res. 1983 Nov;43(11):5538–5543. [PubMed] [Google Scholar]
  9. Berdel W. E., Okamoto S., Danhauser-Riedl S., Hong C. I., Winton E. F., West C. R., Rastetter J., Vogler W. R. Therapeutic activity of 1-beta-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice. Exp Hematol. 1989 May;17(4):364–367. [PubMed] [Google Scholar]
  10. Berger M. R., Schmähl D. Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids. Lipids. 1987 Nov;22(11):935–942. doi: 10.1007/BF02535559. [DOI] [PubMed] [Google Scholar]
  11. Bolscher J. G., Schallier D. C., van Rooy H., Storme G. A., Smets L. A. Modification of cell surface carbohydrates and invasive behavior by an alkyl lysophospholipid. Cancer Res. 1988 Feb 15;48(4):977–982. [PubMed] [Google Scholar]
  12. Chabot M. C., Wykle R. L., Modest E. J., Daniel L. W. Correlation of ether lipid content of human leukemia cell lines and their susceptibility to 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine. Cancer Res. 1989 Aug 15;49(16):4441–4445. [PubMed] [Google Scholar]
  13. Diomede L., Bizzi A., Magistrelli A., Modest E. J., Salmona M., Noseda A. Role of cell cholesterol in modulating antineoplastic ether lipid uptake, membrane effects and cytotoxicity. Int J Cancer. 1990 Aug 15;46(2):341–346. doi: 10.1002/ijc.2910460234. [DOI] [PubMed] [Google Scholar]
  14. Dulisch I., Neumann H. A., Löhr G. W., Andreesen R. Clonogenicity of normal and malignant hematopoietic progenitor cells after exposure to synthetic alkyl-lymphospholipids. Blut. 1985 Dec;51(6):393–399. doi: 10.1007/BF00320725. [DOI] [PubMed] [Google Scholar]
  15. Fleer E. A., Unger C., Kim D. J., Eibl H. Metabolism of ether phospholipids and analogs in neoplastic cells. Lipids. 1987 Nov;22(11):856–861. doi: 10.1007/BF02535544. [DOI] [PubMed] [Google Scholar]
  16. Fujiwara K., Modest E. J., Welander C. E., Wallen C. A. Cytotoxic interactions of heat and an ether lipid analogue in human ovarian carcinoma cells. Cancer Res. 1989 Nov 15;49(22):6285–6289. [PubMed] [Google Scholar]
  17. Glasser L., Somberg L. B., Vogler W. R. Purging murine leukemic marrow with alkyl-lysophospholipids. Blood. 1984 Dec;64(6):1288–1291. [PubMed] [Google Scholar]
  18. Helfman D. M., Barnes K. C., Kinkade J. M., Jr, Vogler W. R., Shoji M., Kuo J. F. Phospholipid-sensitive Ca2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid. Cancer Res. 1983 Jun;43(6):2955–2961. [PubMed] [Google Scholar]
  19. Herrmann D. B., Neumann H. A. Cytotoxic ether phospholipids. Different affinities to lysophosphocholine acyltransferases in sensitive and resistant cells. J Biol Chem. 1986 Jun 15;261(17):7742–7747. [PubMed] [Google Scholar]
  20. Hilgard P., Stekar J., Voegeli R., Engel J., Schumacher W., Eibl H., Unger C., Berger M. R. Characterization of the antitumor activity of hexadecylphosphocholine (D 18506). Eur J Cancer Clin Oncol. 1988 Sep;24(9):1457–1461. doi: 10.1016/0277-5379(88)90336-7. [DOI] [PubMed] [Google Scholar]
  21. Himmelmann A. W., Danhauser-Riedl S., Steinhauser G., Busch R., Modest E. J., Noseda A., Rastetter J., Vogler W. R., Berdel W. E. Cross-resistance pattern of cell lines selected for resistance towards different cytotoxic drugs to membrane-toxic phospholipids in vitro. Cancer Chemother Pharmacol. 1990;26(6):437–443. doi: 10.1007/BF02994095. [DOI] [PubMed] [Google Scholar]
  22. Hoffman D. R., Hoffman L. H., Snyder F. Cytotoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells. Cancer Res. 1986 Nov;46(11):5803–5809. [PubMed] [Google Scholar]
  23. Hofmann J., Ueberall F., Posch L., Maly K., Herrmann D. B., Grunicke H. Synergistic enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C. Lipids. 1989 Apr;24(4):312–317. doi: 10.1007/BF02535169. [DOI] [PubMed] [Google Scholar]
  24. Honma Y., Kasukabe T., Hozumi M., Tsushima S., Nomura H. Induction of differentiation of cultured human and mouse myeloid leukemia cells by alkyl-lysophospholipids. Cancer Res. 1981 Aug;41(8):3211–3216. [PubMed] [Google Scholar]
  25. Kosano H., Takatani O. Increase of transferrin binding induced by an alkyl-lysophospholipid in breast cancer cells. J Lipid Mediat. 1990 Mar-Apr;2(2):117–121. [PubMed] [Google Scholar]
  26. Kosano H., Takatani O. Inhibition by an alkyl-lysophospholipid of the uptake of epidermal growth factor in human breast cancer cell lines in relation to epidermal growth factor internalization. Cancer Res. 1989 Jun 1;49(11):2868–2870. [PubMed] [Google Scholar]
  27. Kosano H., Takatani O. Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid. Cancer Res. 1988 Nov 1;48(21):6033–6036. [PubMed] [Google Scholar]
  28. Kosano H., Yasutomo Y., Kugai N., Nagata N., Inagaki H., Tanaka S., Takatani O. Inhibition of estradiol uptake and transforming growth factor alpha secretion in human breast cancer cell line MCF-7 by an alkyl-lysophospholipid. Cancer Res. 1990 Jun 1;50(11):3172–3175. [PubMed] [Google Scholar]
  29. Kucera L. S., Iyer N., Leake E., Raben A., Modest E. J., Daniel L. W., Piantadosi C. Novel membrane-interactive ether lipid analogs that inhibit infectious HIV-1 production and induce defective virus formation. AIDS Res Hum Retroviruses. 1990 Apr;6(4):491–501. doi: 10.1089/aid.1990.6.491. [DOI] [PubMed] [Google Scholar]
  30. Lazenby C. M., Thompson M. G., Hickman J. A. Elevation of leukemic cell intracellular calcium by the ether lipid SRI 62-834. Cancer Res. 1990 Jun 1;50(11):3327–3330. [PubMed] [Google Scholar]
  31. Leder G. H., Fiebig H. H., Wallbrecher E., Winterhalter B. R., Löhr G. W. In vitro and in vivo cytotoxicity of alkyl lysophospholipid ET-18-OCH3 and thioether lipid BM 41.440. Lipids. 1987 Nov;22(11):958–961. doi: 10.1007/BF02535564. [DOI] [PubMed] [Google Scholar]
  32. Noseda A., Berens M. E., White J. G., Modest E. J. In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells. Cancer Res. 1988 Apr 1;48(7):1788–1791. [PubMed] [Google Scholar]
  33. Noseda A., White J. G., Godwin P. L., Jerome W. G., Modest E. J. Membrane damage in leukemic cells induced by ether and ester lipids: an electron microscopic study. Exp Mol Pathol. 1989 Feb;50(1):69–83. doi: 10.1016/0014-4800(89)90057-9. [DOI] [PubMed] [Google Scholar]
  34. Okamoto S., Olson A. C., Berdel W. E., Vogler W. R. Purging of acute myeloid leukemic cells by ether lipids and hyperthermia. Blood. 1988 Nov;72(5):1777–1783. [PubMed] [Google Scholar]
  35. Okamoto S., Olson A. C., Vogler W. R. Elimination of leukemic cells by the combined use of ether lipids in vitro. Cancer Res. 1987 May 15;47(10):2599–2603. [PubMed] [Google Scholar]
  36. Okamoto S., Olson A. C., Vogler W. R., Winton E. F. Purging leukemic cells from simulated human remission marrow with alkyl-lysophospholipid. Blood. 1987 May;69(5):1381–1387. [PubMed] [Google Scholar]
  37. Runge M. H., Andreesen R., Pfleiderer A., Munder P. G. Destruction of human solid tumors by alkyl lysophospholipids. J Natl Cancer Inst. 1980 Jun;64(6):1301–1306. doi: 10.1093/jnci/64.6.1301. [DOI] [PubMed] [Google Scholar]
  38. Schaefer H. G., Rohdewald P. Determination of the alkyl lysophospholipid derivative ET-18-OCH3, a new antineoplastic drug, in plasma. Clin Chem. 1989 May;35(5):821–823. [PubMed] [Google Scholar]
  39. Schick H. D., Berdel W. E., Fromm M., Fink U., Jehn U., Ulm K., Reichert A., Eibl H., Unger C., Rastetter J. Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro. Lipids. 1987 Nov;22(11):904–910. doi: 10.1007/BF02535552. [DOI] [PubMed] [Google Scholar]
  40. Seewald M. J., Olsen R. A., Sehgal I., Melder D. C., Modest E. J., Powis G. Inhibition of growth factor-dependent inositol phosphate Ca2+ signaling by antitumor ether lipid analogues. Cancer Res. 1990 Aug 1;50(15):4458–4463. [PubMed] [Google Scholar]
  41. Shoji M., Raynor R. L., Berdel W. E., Vogler W. R., Kuo J. F. Effects of thioether phospholipid BM 41.440 on protein kinase C and phorbol ester-induced differentiation of human leukemia HL60 and KG-1 cells. Cancer Res. 1988 Dec 1;48(23):6669–6673. [PubMed] [Google Scholar]
  42. Storme G. A., Berdel W. E., van Blitterswijk W. J., Bruyneel E. A., De Bruyne G. K., Mareel M. M. Antiinvasive effect of racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine on MO4 mouse fibrosarcoma cells in vitro. Cancer Res. 1985 Jan;45(1):351–357. [PubMed] [Google Scholar]
  43. Talmadge J. E., Schneider M., Lenz B., Phillips H., Long C. Immunomodulatory and therapeutic properties of alkyl lysophospholipids in mice. Lipids. 1987 Nov;22(11):871–877. doi: 10.1007/BF02535547. [DOI] [PubMed] [Google Scholar]
  44. Unger C., Eibl H., Breiser A., von Heyden H. W., Engel J., Hilgard P., Sindermann H., Peukert M., Nagel G. A. Hexadecylphosphocholine (D 18506) in the topical treatment of skin metastases: a phase-I trial. Onkologie. 1988 Dec;11(6):295–296. doi: 10.1159/000216563. [DOI] [PubMed] [Google Scholar]
  45. Verdonck L. F., Witteveen E. O., van Heugten H. G., Rozemuller E., Rijksen G. Selective killing of malignant cells from leukemic patients by alkyl-lysophospholipid. Cancer Res. 1990 Jul 1;50(13):4020–4025. [PubMed] [Google Scholar]
  46. Vogler W. R., Somberg L. B., Glasser L. Effect of cryopreservation on purging of leukemic marrow with alkyl-lysophospholipids. Exp Hematol. 1987 May;15(4):360–364. [PubMed] [Google Scholar]
  47. Vogler W. R., Whigham E., Bennett W. D., Olson A. C. Effect of alkyl-lysophospholipids on phosphatidylcholine biosynthesis in leukemic cell lines. Exp Hematol. 1985 Aug;13(7):629–633. [PubMed] [Google Scholar]

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