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. 1991 Aug;64(2):299–306. doi: 10.1038/bjc.1991.296

Assessment of quality of life in small-cell lung cancer using a Daily Diary Card developed by the Medical Research Council Lung Cancer Working Party.

P M Fayers 1, N M Bleehen 1, D J Girling 1, R J Stephens 1
PMCID: PMC1977498  PMID: 1654074

Abstract

Three hundred and sixty-nine patients in an MRC study of combination chemotherapy and radiotherapy for small-cell lung cancer of limited extent were asked to complete a Daily Diary Card which enabled an assessment of their quality of life to be made during and after treatment. The information derived from the card suggests that although cytotoxic chemotherapy has an adverse effect upon quality of life, this impairment only affects the first 2 or 3 days following each course of treatment, although there is also a small deterioration which may be associated with the 'nadir' effect of the blood counts about 10 days after each course. These results should assist physicians in counselling patients about the likely effects of treatment. Just over half of the patients (196) were subsequently randomised to either a further six courses of maintenance chemotherapy or no further chemotherapy, and it is also shown that the patients allocated to no maintenance chemotherapy experienced a gradually deteriorating quality of life, as opposed to the brief but more severe adverse effects which occurred following each course in the maintenance chemotherapy group; this supports the hypothesis of a palliative effect in this latter group. The findings demonstrate that the Daily Diary Card is a sensitive instrument capable of yielding useful information.

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Selected References

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  1. Boyd N. F., Selby P. J., Sutherland H. J., Hogg S. Measurement of the clinical status of patients with breast cancer: evidence for the validity of self assessment with linear analogue scales. J Clin Epidemiol. 1988;41(3):243–250. doi: 10.1016/0895-4356(88)90128-x. [DOI] [PubMed] [Google Scholar]
  2. Brinkley D. Quality of life in cancer trials. Br Med J (Clin Res Ed) 1985 Sep 14;291(6497):685–686. doi: 10.1136/bmj.291.6497.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Clark A., Fallowfield L. J. Quality of life measurements in patients with malignant disease: a review. J R Soc Med. 1986 Mar;79(3):165–169. doi: 10.1177/014107688607900311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Derogatis L. R., Spencer P. M. Psychometric issues in the psychological assessment of the cancer patient. Cancer. 1984 May 15;53(10 Suppl):2228–2234. doi: 10.1002/cncr.1984.53.s10.2228. [DOI] [PubMed] [Google Scholar]
  5. Fallowfield L. J., Baum M., Maguire G. P. Do psychological studies upset patients? J R Soc Med. 1987 Jan;80(1):59–59. doi: 10.1177/014107688708000124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fayers P. M., Jones D. R. Measuring and analysing quality of life in cancer clinical trials: a review. Stat Med. 1983 Oct-Dec;2(4):429–446. doi: 10.1002/sim.4780020402. [DOI] [PubMed] [Google Scholar]
  7. Feinstein A. R., Josephy B. R., Wells C. K. Scientific and clinical problems in indexes of functional disability. Ann Intern Med. 1986 Sep;105(3):413–420. doi: 10.7326/0003-4819-105-3-413. [DOI] [PubMed] [Google Scholar]
  8. Geddes D. M., Dones L., Hill E., Law K., Harper P. G., Spiro S. G., Tobias J. S., Souhami R. L. Quality of life during chemotherapy for small cell lung cancer: assessment and use of a daily diary card in a randomized trial. Eur J Cancer. 1990 Apr;26(4):484–492. doi: 10.1016/0277-5379(90)90022-l. [DOI] [PubMed] [Google Scholar]
  9. Goldberg D. P., Hillier V. F. A scaled version of the General Health Questionnaire. Psychol Med. 1979 Feb;9(1):139–145. doi: 10.1017/s0033291700021644. [DOI] [PubMed] [Google Scholar]
  10. Kaplan R. M., Bush J. W., Berry C. C. Health status: types of validity and the index of well-being. Health Serv Res. 1976 Winter;11(4):478–507. [PMC free article] [PubMed] [Google Scholar]
  11. McNeil B. J., Weichselbaum R., Pauker S. G. Speech and survival: tradeoffs between quality and quantity of life in laryngeal cancer. N Engl J Med. 1981 Oct 22;305(17):982–987. doi: 10.1056/NEJM198110223051704. [DOI] [PubMed] [Google Scholar]
  12. Selby P. J., Chapman J. A., Etazadi-Amoli J., Dalley D., Boyd N. F. The development of a method for assessing the quality of life of cancer patients. Br J Cancer. 1984 Jul;50(1):13–22. doi: 10.1038/bjc.1984.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Smith A. Qualms about QALYs. Lancet. 1987 May 16;1(8542):1134–1136. doi: 10.1016/s0140-6736(87)91685-0. [DOI] [PubMed] [Google Scholar]
  14. Stewart A. L., Ware J. E., Jr, Brook R. H. Advances in the measurement of functional status: construction of aggregate indexes. Med Care. 1981 May;19(5):473–488. doi: 10.1097/00005650-198105000-00001. [DOI] [PubMed] [Google Scholar]
  15. Williams A. Economics of coronary artery bypass grafting. Br Med J (Clin Res Ed) 1985 Aug 3;291(6491):326–329. doi: 10.1136/bmj.291.6491.326. [DOI] [PMC free article] [PubMed] [Google Scholar]

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