Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1991 Aug;64(2):365–368. doi: 10.1038/bjc.1991.308

Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.

J H Anderson 1, N Willmott 1, R Bessent 1, W J Angerson 1, D J Kerr 1, C S McArdle 1
PMCID: PMC1977499  PMID: 1892766

Abstract

Regionally-administered, drug-loaded microspheres have a potential role in the treatment of renal tumours. Vasoactive agents, for example, angiotensin II, may allow selective delivery of microspheres to tumour. The present study defines the regional advantage that may be obtained from angiotensin II by quantifying tumour and normal kidney blood flow using radiolabelled microsphere renal perfusion studies and per-operative laser-doppler flow measurements. Angiotensin II increased microsphere distribution to tumour, relative to normal kidney, by a factor of four. This enhancement was associated with an absolute increase in tumour blood flow.

Full text

PDF
365

Images in this article

367Figure 1
on p.367

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABRAMS H. L. ALTERED DRUG RESPONSE OF TUMOUR VESSELS IN MAN. Nature. 1964 Jan 11;201:167–170. doi: 10.1038/201167a0. [DOI] [PubMed] [Google Scholar]
  2. Ekelund L., Göthlin J., Lunderquist A. Diagnostic improvement with angiotensin in renal angiography. Radiology. 1972 Oct;105(1):33–37. doi: 10.1148/105.1.33. [DOI] [PubMed] [Google Scholar]
  3. Harris D. T. Hormonal therapy and chemotherapy of renal-cell carcinoma. Semin Oncol. 1983 Dec;10(4):422–430. [PubMed] [Google Scholar]
  4. Kato T., Nemoto R., Mori H., Takahashi M., Tamakawa Y. Transcatheter arterial chemoembolization of renal cell carcinoma with microencapsulated mitomycin C. J Urol. 1981 Jan;125(1):19–24. doi: 10.1016/s0022-5347(17)54880-6. [DOI] [PubMed] [Google Scholar]
  5. Kerr D. J., Willmott N., McKillop J. H., Cummings J., Lewi H. J., McArdle C. S. Target organ disposition and plasma pharmacokinetics of doxorubicin incorporated into albumin microspheres after intrarenal arterial administration. Cancer. 1988 Sep 1;62(5):878–883. doi: 10.1002/1097-0142(19880901)62:5<878::aid-cncr2820620505>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  6. Lang E. K. Superselective arterial catheterization as a vehicle for delivering radioactive infarct particles to tumors. Radiology. 1971 Feb;98(2):391–399. doi: 10.1148/98.2.391. [DOI] [PubMed] [Google Scholar]
  7. Lang E. K. Superselective arterial catheterization of tumors of the urogenital tract: a modality used for perfusion with chemotherapeutic agents and infarction with radioactive pellets. J Urol. 1970 Jul;104(1):16–25. doi: 10.1016/s0022-5347(17)61663-x. [DOI] [PubMed] [Google Scholar]
  8. McArdle C. S., Lewi H., Hansell D., Kerr D. J., McKillop J., Willmott N. Cytotoxic-loaded albumin microspheres: a novel approach to regional chemotherapy. Br J Surg. 1988 Feb;75(2):132–134. doi: 10.1002/bjs.1800750214. [DOI] [PubMed] [Google Scholar]
  9. Patel N. P., Lavengood R. W. Renal cell carcinoma: natural history and results of treatment. J Urol. 1978 Jun;119(6):722–726. doi: 10.1016/s0022-5347(17)57611-9. [DOI] [PubMed] [Google Scholar]
  10. Widder K. J., Senyei A. E., Ranney D. F. Magnetically responsive microspheres and other carriers for the biophysical targeting of antitumor agents. Adv Pharmacol Chemother. 1979;16:213–271. doi: 10.1016/s1054-3589(08)60246-x. [DOI] [PubMed] [Google Scholar]
  11. Willmott N., Cummings J., Stuart J. F., Florence A. T. Adriamycin-loaded albumin microspheres: preparation, in vivo distribution and release in the rat. Biopharm Drug Dispos. 1985 Jan-Mar;6(1):91–104. doi: 10.1002/bdd.2510060111. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES