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. 1991 Aug;64(2):227–232. doi: 10.1038/bjc.1991.281

Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.

S Gledhill 1, A Gallagher 1, D B Jones 1, A S Krajewski 1, F E Alexander 1, E Klee 1, D H Wright 1, C O'Brien 1, D E Onions 1, R F Jarrett 1
PMCID: PMC1977506  PMID: 1654072

Abstract

Thirty-five cases of Hodgkin's disease (HD) were analysed for the presence of Epstein-Barr virus (EBV) and human herpesvirus-6 (HHV-6) DNA. EBV genomes were detected in 11/35 cases while none of the cases was positive for HHV-6. Ten of the EBV-positive cases were subsequently analysed using a probe for the terminal region of the virus; the results suggested that the EBV-infected cells were clonally expanded. EBV subtypes specific DNA amplification was used to demonstrate that EBV subtype A, and not subtype B was present in the EBV-positive cases. The age distribution of the EBV-positive cases indicated a statistically significant trend for an increase in positivity with increasing age. This is the first indication that EBV is significantly associated with any subset of HD patients.

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Selected References

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