Abstract
Vasoactive drugs have a variety of effects upon splanchnic and hepatic haemodynamics which may alter tumour blood flow and potentiate the delivery of a chemotherapeutic drug to hepatic tumour. We have investigated the effects of vasopressin infusion on hepatic tumour blood flow in an experimental model of liver tumour. Hepatic tumour was induced by the intraportal inoculation of HSN sarcoma cells. Hepatic and splanchnic blood flow was determined using a dual reference microsphere technique before and after an intravenous infusion of vasopressin at a dose of 0.1 mU kg-1 min-1 for 10 min. There was a significant increase in systemic arterial blood pressure associated with a rise in portal venous inflow (P less than 0.01, Wilcoxen Signed rank Test) and a significant fall in hepatic arterial flow (P less than 0.05). The tumour: liver blood flow ratio was significantly increased by vasopressin infusion (P less than 0.02). Vasopressin infusion decreases hepatic arterial flow and increases tumour blood flow which may potentiate the delivery of a regionally delivered chemotherapeutic drug to hepatic tumour.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Goldberg J. A., Kerr D. J., Wilmott N., McKillop J. H., McArdle C. S. Regional chemotherapy for colorectal liver metastases: a phase II evaluation of targeted hepatic arterial 5-fluorouracil for colorectal liver metastases. Br J Surg. 1990 Nov;77(11):1238–1240. doi: 10.1002/bjs.1800771114. [DOI] [PubMed] [Google Scholar]
- Jenkins S. A., Day D. W., Mooney B., Devitt P., Baxter J. N., Taylor I., Shields R. The effects of vasopressin on hepatic haemodynamics in the cirrhotic and non-cirrhotic rat. Langenbecks Arch Chir. 1985;365(2):135–146. doi: 10.1007/BF01261140. [DOI] [PubMed] [Google Scholar]
- Jenkins S. A., Mooney B., Taylor I., Shields R. Effect of vasopressin on liver blood flow in the hypophysectomised rat. Digestion. 1984;29(3):177–182. doi: 10.1159/000199028. [DOI] [PubMed] [Google Scholar]
- Kemeny N., Daly J., Reichman B., Geller N., Botet J., Oderman P. Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. A randomized trial. Ann Intern Med. 1987 Oct;107(4):459–465. doi: 10.7326/0003-4819-107-4-459. [DOI] [PubMed] [Google Scholar]
- Mattson J., Appelgren L., Karlsson L., Peterson H. I. Influence of vasoactive drugs and ischaemia on intra-tumour blood flow distribution. Eur J Cancer. 1978 Jul;14(7):761–764. doi: 10.1016/0014-2964(78)90006-3. [DOI] [PubMed] [Google Scholar]
- McDevitt D. G., Nies A. S. Simultaneous measurement of cardiac output and its distribution with microspheres in the rat. Cardiovasc Res. 1976 Jul;10(4):494–498. doi: 10.1093/cvr/10.4.494. [DOI] [PubMed] [Google Scholar]
- Rapoport A. H., Burleson R. L. Survival of patients treated with systemic fluorouracil for hepatic metastases. Surg Gynecol Obstet. 1970 May;130(5):773–777. [PubMed] [Google Scholar]
- Sasaki Y., Imaoka S., Hasegawa Y., Nakano S., Ishikawa O., Ohigashi H., Taniguchi K., Koyama H., Iwanaga T., Terasawa T. Changes in distribution of hepatic blood flow induced by intra-arterial infusion of angiotensin II in human hepatic cancer. Cancer. 1985 Jan 15;55(2):311–316. doi: 10.1002/1097-0142(19850115)55:2<311::aid-cncr2820550202>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]