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. 1991 Aug;64(2):296–298. doi: 10.1038/bjc.1991.295

Tumourigenic multidrug-resistant HT1080 cells do not overexpress receptors for epidermal growth factor.

M L Slovak 1, S E Mirski 1, S P Cole 1, J H Gerlach 1, K H Yohem 1, J M Trent 1
PMCID: PMC1977511  PMID: 1679997

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck W. T., Mueller T. J., Tanzer L. R. Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts. Cancer Res. 1979 Jun;39(6 Pt 1):2070–2076. [PubMed] [Google Scholar]
  2. Carlin C. R., Knowles B. B. Identity of human epidermal growth factor (EGF) receptor with glycoprotein SA-7: evidence for differential phosphorylation of the two components of the EGF receptor from A431 cells. Proc Natl Acad Sci U S A. 1982 Aug;79(16):5026–5030. doi: 10.1073/pnas.79.16.5026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carpenter G. Properties of the receptor for epidermal growth factor. Cell. 1984 Jun;37(2):357–358. doi: 10.1016/0092-8674(84)90365-9. [DOI] [PubMed] [Google Scholar]
  4. Cole S. P., Downes H. F., Slovak M. L. Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein. Br J Cancer. 1989 Jan;59(1):42–46. doi: 10.1038/bjc.1989.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Collard J. G., van de Poll M., Scheffer A., Roos E., Hopman A. H., Geurts van Kessel A. H., van Dongen J. J. Location of genes involved in invasion and metastasis on human chromosome 7. Cancer Res. 1987 Dec 15;47(24 Pt 1):6666–6670. [PubMed] [Google Scholar]
  6. Downward J., Yarden Y., Mayes E., Scrace G., Totty N., Stockwell P., Ullrich A., Schlessinger J., Waterfield M. D. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 1984 Feb 9;307(5951):521–527. doi: 10.1038/307521a0. [DOI] [PubMed] [Google Scholar]
  7. Fojo A. T., Ueda K., Slamon D. J., Poplack D. G., Gottesman M. M., Pastan I. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A. 1987 Jan;84(1):265–269. doi: 10.1073/pnas.84.1.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gill G. N., Weber W., Thompson D. M., Lin C., Evans R. M., Rosenfeld M. G., Gamou S., Shimizu N. Relationship between production of epidermal growth factor receptors, gene amplification, and chromosome 7 translocation in variant A431 cells. Somat Cell Mol Genet. 1985 Jul;11(4):309–318. doi: 10.1007/BF01534689. [DOI] [PubMed] [Google Scholar]
  9. Hill A. B., Beck W. T., Trent J. M. Cytogenetic and molecular characterization of tumors in nude mice derived from a multidrug-resistant human leukemia cell line. Cancer Res. 1988 Jan 15;48(2):393–398. [PubMed] [Google Scholar]
  10. Honegger A. M., Dull T. J., Felder S., Van Obberghen E., Bellot F., Szapary D., Schmidt A., Ullrich A., Schlessinger J. Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell. 1987 Oct 23;51(2):199–209. doi: 10.1016/0092-8674(87)90147-4. [DOI] [PubMed] [Google Scholar]
  11. Merlino G. T., Xu Y. H., Ishii S., Clark A. J., Semba K., Toyoshima K., Yamamoto T., Pastan I. Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science. 1984 Apr 27;224(4647):417–419. doi: 10.1126/science.6200934. [DOI] [PubMed] [Google Scholar]
  12. Meyers M. B., Merluzzi V. J., Spengler B. A., Biedler J. L. Epidermal growth factor receptor is increased in multidrug-resistant Chinese hamster and mouse tumor cells. Proc Natl Acad Sci U S A. 1986 Aug;83(15):5521–5525. doi: 10.1073/pnas.83.15.5521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mirski S. E., Gerlach J. H., Cole S. P. Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin. Cancer Res. 1987 May 15;47(10):2594–2598. [PubMed] [Google Scholar]
  14. Miyamoto H. Establishment and characterization of an adriamycin-resistant subline of human small cell lung cancer cells. Acta Med Okayama. 1986 Apr;40(2):65–73. doi: 10.18926/AMO/31923. [DOI] [PubMed] [Google Scholar]
  15. Rémy J. J., Belehradek J., Jacquemin-Sablon A. Expression of drug sensitivity and tumorigenicity in intraspecies hybrids between 9-hydroxyellipticine-sensitive and -resistant cells. Cancer Res. 1984 Oct;44(10):4587–4593. [PubMed] [Google Scholar]
  16. Slovak M. L., Hoeltge G. A., Dalton W. S., Trent J. M. Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines. Cancer Res. 1988 May 15;48(10):2793–2797. [PubMed] [Google Scholar]
  17. Slovak M. L., Hoeltge G. A., Trent J. M. Cytogenetic alterations associated with the acquisition of doxorubicin resistance: possible significance of chromosome 7 alterations. Cancer Res. 1987 Dec 15;47(24 Pt 1):6646–6652. [PubMed] [Google Scholar]
  18. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  19. Thomas P. S. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201–5205. doi: 10.1073/pnas.77.9.5201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Zuckier G., Tritton T. R. Adriamycin causes up regulation of epidermal growth factor receptors in actively growing cells. Exp Cell Res. 1983 Oct;148(1):155–161. doi: 10.1016/0014-4827(83)90195-7. [DOI] [PubMed] [Google Scholar]

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