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. 1991 Aug;64(2):357–360. doi: 10.1038/bjc.1991.306

Proliferation in human bladder carcinoma measured by Ki-67 antibody labelling: its potential clinical importance.

C Bush 1, P Price 1, J Norton 1, C S Parkins 1, M J Bailey 1, J Boyd 1, C R Jones 1, R P A'Hern 1, A Horwich 1
PMCID: PMC1977528  PMID: 1892764

Abstract

Ki-67 is a monoclonal antibody which recognises a human nuclear antigen expressed in proliferating cells. The antibody was used to assess proliferation in primary human bladder tumours from 64 patients. Ki-67 index (the number of Ki-67 positive tumour cells divided by the total number of tumour cells %) was derived from 59 tumours. A wide range of Ki-67 indices were recorded, range 3.0-65.8%, mean 20.2%. The Ki-67 index correlated with known prognostic factors: T stage (P = 0.002) and histological grade (P less than 0.001), early stage disease and more differentiated tumours having lower Ki-67 indices. Patients with invasive disease (21 patients) had significantly higher Ki-67 indices than those with non-invasive disease (P = 0.01). Patients with metastatic disease at presentation (four cases) all had a Ki-67 index of greater than or equal to 29%. Ki-67 antibody staining is a simple technique for assessing the proliferation fraction than can be performed on a small amount of tissue taken at routine biopsy without prior injection of thymidine analogues.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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