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. 1992 Apr;65(4):601–607. doi: 10.1038/bjc.1992.122

Influence of menstrual cycle, parity and oral contraceptive use on steroid hormone receptors in normal breast.

S Battersby 1, B J Robertson 1, T J Anderson 1, R J King 1, K McPherson 1
PMCID: PMC1977560  PMID: 1562470

Abstract

Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for natural cycle and oral contraceptive (OC) cycles indicated down-regulation by progestins. Progesterone receptor did not vary significantly in natural cycles, but increased steadily through OC cycles. This study provides strong evidence that both oestrogen and progesterone influence breast epithelium, but dissimilarities from the endometrium are apparent. The interval since pregnancy had a significant negative effect on frequency and score of oestrogen receptor and score of progesterone receptor. Multivariate analysis established the phase of cycle and OC use as independent significant influences on oestrogen receptor. The interval since pregnancy was an independent significant factor for both oestrogen and progesterone receptor presence.

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Selected References

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  1. Anderson T. J., Battersby S., King R. J., McPherson K., Going J. J. Oral contraceptive use influences resting breast proliferation. Hum Pathol. 1989 Dec;20(12):1139–1144. doi: 10.1016/s0046-8177(89)80003-6. [DOI] [PubMed] [Google Scholar]
  2. Battersby S., Anderson T. J. Histological changes in breast tissue that characterize recent pregnancy. Histopathology. 1989 Oct;15(4):415–419. doi: 10.1111/j.1365-2559.1989.tb01593.x. [DOI] [PubMed] [Google Scholar]
  3. Chalbos D., Chambon M., Ailhaud G., Rochefort H. Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cells. J Biol Chem. 1987 Jul 25;262(21):9923–9926. [PubMed] [Google Scholar]
  4. Chalbos D., Escot C., Joyeux C., Tissot-Carayon M. J., Pages A., Rochefort H. Expression of the progestin-induced fatty acid synthetase in benign mastopathies and breast cancer as measured by RNA in situ hybridization. J Natl Cancer Inst. 1990 Apr 4;82(7):602–606. doi: 10.1093/jnci/82.7.602. [DOI] [PubMed] [Google Scholar]
  5. Helin H. J., Helle M. J., Helin M. L., Isola J. J. Immunocytochemical detection of estrogen and progesterone receptors in 124 human breast cancers. Am J Clin Pathol. 1988 Aug;90(2):137–142. doi: 10.1093/ajcp/90.2.137. [DOI] [PubMed] [Google Scholar]
  6. Howie P. W. The progestogen-only pill. Br J Obstet Gynaecol. 1985 Oct;92(10):1001–1002. doi: 10.1111/j.1471-0528.1985.tb02993.x. [DOI] [PubMed] [Google Scholar]
  7. Jacquemier J. D., Hassoun J., Torrente M., Martin P. M. Distribution of estrogen and progesterone receptors in healthy tissue adjacent to breast lesions at various stages--immunohistochemical study of 107 cases. Breast Cancer Res Treat. 1990 Feb;15(2):109–117. doi: 10.1007/BF01810783. [DOI] [PubMed] [Google Scholar]
  8. Joyeux C., Chalbos D., Rochefort H. Effects of progestins and menstrual cycle on fatty acid synthetase and progesterone receptor in human mammary glands. J Clin Endocrinol Metab. 1990 May;70(5):1438–1444. doi: 10.1210/jcem-70-5-1438. [DOI] [PubMed] [Google Scholar]
  9. Lessey B. A., Killam A. P., Metzger D. A., Haney A. F., Greene G. L., McCarty K. S., Jr Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab. 1988 Aug;67(2):334–340. doi: 10.1210/jcem-67-2-334. [DOI] [PubMed] [Google Scholar]
  10. MacMahon B., Cole P., Lin T. M., Lowe C. R., Mirra A. P., Ravnihar B., Salber E. J., Valaoras V. G., Yuasa S. Age at first birth and breast cancer risk. Bull World Health Organ. 1970;43(2):209–221. [PMC free article] [PubMed] [Google Scholar]
  11. Markopoulos C., Berger U., Wilson P., Gazet J. C., Coombes R. C. Oestrogen receptor content of normal breast cells and breast carcinomas throughout the menstrual cycle. Br Med J (Clin Res Ed) 1988 May 14;296(6633):1349–1351. doi: 10.1136/bmj.296.6633.1349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. McCarty K. S., Jr, Miller L. S., Cox E. B., Konrath J., McCarty K. S., Sr Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch Pathol Lab Med. 1985 Aug;109(8):716–721. [PubMed] [Google Scholar]
  13. McCarty K. S., Jr Proliferative stimuli in the normal breast: estrogens or progestins? Hum Pathol. 1989 Dec;20(12):1137–1138. doi: 10.1016/s0046-8177(89)80002-4. [DOI] [PubMed] [Google Scholar]
  14. McManus M. J., Welsch C. W. The effect of estrogen, progesterone, thyroxine, and human placental lactogen on DNA synthesis of human breast ductal epithelium maintained in athymic nude mice. Cancer. 1984 Nov 1;54(9):1920–1927. doi: 10.1002/1097-0142(19841101)54:9<1920::aid-cncr2820540924>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  15. Paterson D. A., Reid C. P., Anderson T. J., Hawkins R. A. Assessment of oestrogen receptor content of breast carcinoma by immunohistochemical techniques on fixed and frozen tissue and by biochemical ligand binding assay. J Clin Pathol. 1990 Jan;43(1):46–51. doi: 10.1136/jcp.43.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Petersen O. W., Høyer P. E., van Deurs B. Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue. Cancer Res. 1987 Nov 1;47(21):5748–5751. [PubMed] [Google Scholar]
  17. Petrakis N. L., Wrensch M. R., Ernster V. L., Miike R., Murai J., Simberg N., Siiteri P. K. Influence of pregnancy and lactation on serum and breast fluid estrogen levels: implications for breast cancer risk. Int J Cancer. 1987 Nov 15;40(5):587–591. doi: 10.1002/ijc.2910400502. [DOI] [PubMed] [Google Scholar]
  18. Press M. F., Greene G. L. Localization of progesterone receptor with monoclonal antibodies to the human progestin receptor. Endocrinology. 1988 Mar;122(3):1165–1175. doi: 10.1210/endo-122-3-1165. [DOI] [PubMed] [Google Scholar]
  19. Press M. F., Nousek-Goebl N., King W. J., Herbst A. L., Greene G. L. Immunohistochemical assessment of estrogen receptor distribution in the human endometrium throughout the menstrual cycle. Lab Invest. 1984 Nov;51(5):495–503. [PubMed] [Google Scholar]
  20. Shintaku I. P., Said J. W. Detection of estrogen receptors with monoclonal antibodies in routinely processed formalin-fixed paraffin sections of breast carcinoma. Use of DNase pretreatment to enhance sensitivity of the reaction. Am J Clin Pathol. 1987 Feb;87(2):161–167. doi: 10.1093/ajcp/87.2.161. [DOI] [PubMed] [Google Scholar]
  21. Silva J. S., Georgiade G. S., Dilley W. G., McCarty K. S., Sr, Wells S. A., Jr, McCarty K. S., Jr Menstrual cycle-dependent variations of breast cyst fluid proteins and sex steroid receptors in the normal human breast. Cancer. 1983 Apr 1;51(7):1297–1302. doi: 10.1002/1097-0142(19830401)51:7<1297::aid-cncr2820510720>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  22. Stefanini M., De Martino C., Zamboni L. Fixation of ejaculated spermatozoa for electron microscopy. Nature. 1967 Oct 14;216(5111):173–174. doi: 10.1038/216173a0. [DOI] [PubMed] [Google Scholar]
  23. Thomas D. B. Oral contraceptives and breast cancer: review of the epidemiologic literature. Contraception. 1991 Jun;43(6):597–642. doi: 10.1016/0010-7824(91)90006-2. [DOI] [PubMed] [Google Scholar]
  24. Vogel P. M., Georgiade N. G., Fetter B. F., Vogel F. S., McCarty K. S., Jr The correlation of histologic changes in the human breast with the menstrual cycle. Am J Pathol. 1981 Jul;104(1):23–34. [PMC free article] [PubMed] [Google Scholar]
  25. Williams G., Anderson E., Howell A., Watson R., Coyne J., Roberts S. A., Potten C. S. Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast. Int J Cancer. 1991 May 10;48(2):206–210. doi: 10.1002/ijc.2910480209. [DOI] [PubMed] [Google Scholar]

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