Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1992 Mar;65(3):417–420. doi: 10.1038/bjc.1992.85

Prognosis for surgically treated gastric cancer patients is poorer for women than men in all patients under age 50.

Y Maehara 1, A Watanabe 1, Y Kakeji 1, Y Emi 1, S Moriguchi 1, H Anai 1, K Sugimachi 1
PMCID: PMC1977603  PMID: 1558797

Abstract

From 1965 to 1983, 1031 patients (689 men and 342 women) with advanced gastric cancer underwent gastric resection in our department. A retrospective study was done with special reference to the sex of the patients. The age, tumour size and location, Borrmann type, and histology were considered as the sex-related associations. The survival rate of women under age 50 years was lower than that of men, with a significant difference (P less than 0.01), and the 10-year survival rate was 39.2% for the men and 29.3% for the women. A multivariate analysis showed that the operative curability (relative risk: 2.11), lymph node metastasis (relative risk: 1.37), depth of invasion (relative risk: 1.30) and tumour size (relative risk: 1.05), all significant prognostic factors, differed between the men and women under age 50 years, and the survival rate for women was lower. Thus, early detection of gastric cancer is crucial to improve the survival of women under age 50 years. Postoperative chemotherapy may be considered for those with an advanced gastric cancer.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong C. P., Dent D. M. Factors influencing prognosis in carcinoma of the stomach. Surg Gynecol Obstet. 1986 Apr;162(4):343–348. [PubMed] [Google Scholar]
  2. Baba H., Korenaga D., Okamura T., Saito A., Sugimachi K. Prognostic factors in gastric cancer with serosal invasion. Univariate and multivariate analyses. Arch Surg. 1989 Sep;124(9):1061–1064. doi: 10.1001/archsurg.1989.01410090071015. [DOI] [PubMed] [Google Scholar]
  3. Bloss R. S., Miller T. A., Copeland E. M., 3rd Carcinoma of the stomach in the young adult. Surg Gynecol Obstet. 1980 Jun;150(6):883–886. [PubMed] [Google Scholar]
  4. Boku T., Nakane Y., Okusa T., Hirozane N., Imabayashi N., Hioki K., Yamamoto M. Strategy for lymphadenectomy of gastric cancer. Surgery. 1989 May;105(5):585–592. [PubMed] [Google Scholar]
  5. Gunduz N., Fisher B., Saffer E. A. Effect of surgical removal on the growth and kinetics of residual tumor. Cancer Res. 1979 Oct;39(10):3861–3865. [PubMed] [Google Scholar]
  6. Kodama Y., Sugimachi K., Soejima K., Matsusaka T., Inokuchi K. Evaluation of extensive lymph node dissection for carcinoma of the stomach. World J Surg. 1981 Mar;5(2):241–248. doi: 10.1007/BF01658301. [DOI] [PubMed] [Google Scholar]
  7. Korenaga D., Haraguchi M., Okamura T., Baba H., Saito A., Sugimachi K. DNA ploidy and tumor invasion in human gastric cancer. Histopathologic differentiation. Arch Surg. 1989 Mar;124(3):314–318. doi: 10.1001/archsurg.1989.01410030064011. [DOI] [PubMed] [Google Scholar]
  8. Korenaga D., Tsujitani S., Haraguchi M., Okamura T., Tamada R., Sugimachi K., Akazawa K., Nose Y. Long-term survival in Japanese patients with far advanced carcinoma of the stomach. World J Surg. 1988 Apr;12(2):236–240. doi: 10.1007/BF01658063. [DOI] [PubMed] [Google Scholar]
  9. LAUREN P. THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965;64:31–49. doi: 10.1111/apm.1965.64.1.31. [DOI] [PubMed] [Google Scholar]
  10. Maehara Y., Anai H., Kusumoto H., Sugimachi K. Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma. Eur J Surg Oncol. 1987 Jun;13(3):203–206. [PubMed] [Google Scholar]
  11. Maehara Y., Moriguchi S., Kakeji Y., Orita H., Haraguchi M., Korenaga D., Sugimachi K. Prognostic factors in adenocarcinoma in the upper one-third of the stomach. Surg Gynecol Obstet. 1991 Sep;173(3):223–226. [PubMed] [Google Scholar]
  12. Maehara Y., Moriguchi S., Sakaguchi Y., Emi Y., Kohnoe S., Tsujitani S., Sugimachi K. Adjuvant chemotherapy enhances long-term survival of patients with advanced gastric cancer following curative resection. J Surg Oncol. 1990 Nov;45(3):169–172. doi: 10.1002/jso.2930450307. [DOI] [PubMed] [Google Scholar]
  13. Maehara Y., Moriguchi S., Yoshida M., Takahashi I., Korenaga D., Sugimachi K. Splenectomy does not correlate with length of survival in patients undergoing curative total gastrectomy for gastric carcinoma. Univariate and multivariate analyses. Cancer. 1991 Jun 15;67(12):3006–3009. doi: 10.1002/1097-0142(19910615)67:12<3006::aid-cncr2820671213>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  14. Maehara Y., Orita H., Moriguchi S., Emi Y., Haraguchi M., Sugimachi K. Lower survival rate for patients under 30 years of age and surgically treated for gastric carcinoma. Br J Cancer. 1991 Jun;63(6):1015–1017. doi: 10.1038/bjc.1991.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Maehara Y., Watanabe A., Kakeji Y., Baba H., Kohnoe S., Sugimachi K. Postgastrectomy prescription of mitomycin C and UFT for patients with stage IV gastric carcinoma. Am J Surg. 1990 Sep;160(3):242–244. doi: 10.1016/s0002-9610(06)80015-2. [DOI] [PubMed] [Google Scholar]
  16. Matley P. J., Dent D. M., Madden M. V., Price S. K. Gastric carcinoma in young adults. Ann Surg. 1988 Nov;208(5):593–596. doi: 10.1097/00000658-198811000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mitsudomi T., Tateishi M., Oka T., Yano T., Ishida T., Sugimachi K. Longer survival after resection of non-small cell lung cancer in Japanese women. Ann Thorac Surg. 1989 Nov;48(5):639–642. doi: 10.1016/0003-4975(89)90779-0. [DOI] [PubMed] [Google Scholar]
  18. Nishi K., Tokunaga A., Shimizu Y., Yoshiyuki T., Wada M., Matsukura N., Tanaka N., Onda M., Asano G. Immunohistochemical study of intracellular estradiol in human gastric cancer. Cancer. 1987 Apr 1;59(7):1328–1332. doi: 10.1002/1097-0142(19870401)59:7<1328::aid-cncr2820590716>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  19. Stemmermann G. N., Brown C. A survival study of intestinal and diffuse types of gastric carcinoma. Cancer. 1974 Apr;33(4):1190–1195. doi: 10.1002/1097-0142(197404)33:4<1190::aid-cncr2820330444>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  20. Sugano H., Nakamura K., Kato Y. Pathological studies of human gastric cancer. Acta Pathol Jpn. 1982;32 (Suppl 2):329–347. [PubMed] [Google Scholar]
  21. Sugimachi K., Matsuoka H., Matsufuji H., Maekawa S., Kai H., Okudaira Y. Survival rates of women with carcinoma of the esophagus exceed those of men. Surg Gynecol Obstet. 1987 Jun;164(6):541–544. [PubMed] [Google Scholar]
  22. Tso P. L., Bringaze W. L., 3rd, Dauterive A. H., Correa P., Cohn I., Jr Gastric carcinoma in the young. Cancer. 1987 Apr 1;59(7):1362–1365. doi: 10.1002/1097-0142(19870401)59:7<1362::aid-cncr2820590722>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES