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. 1991 Oct;64(4):689–692. doi: 10.1038/bjc.1991.382

Anticoagulant treatment does not affect the action of flavone acetic acid in tumour-bearing mice.

G Thurston 1, K A Smith 1, J C Murray 1
PMCID: PMC1977683  PMID: 1911218

Abstract

Flavone acetic acid (FAA) is a novel antitumour agent that has a profound effect on the vasculature in murine tumour models. Previously we have shown that FAA induces a coagulopathy and thrombocytopaenia in tumour-bearing mice, and the purpose of the present study was to determine the significance of the FAA-induced intravascular coagulation in the antitumour action of FAA. Several anticoagulant agents were tested for their effectiveness in altering ex vivo coagulation of murine plasma; heparin and ancrod were found to be most effective. These agents were administered to tumour-bearing mice prior to FAA and TNF treatment with little effect on the induced regrowth delay. However: the FAA-induced consumption of platelets in tumour-bearing mice was not blocked by anticoagulant treatment. These data suggest that platelet consumption occurs independently of the normal coagulation pathway, and further that fibrin deposition may not be a major factor in the antitumour action of FAA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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