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. 1992 Aug;66(2):342–344. doi: 10.1038/bjc.1992.267

Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.

P Giacomini 1, M Mottolese 1, R Fraioli 1, M Benevolo 1, I Venturo 1, P G Natali 1
PMCID: PMC1977801  PMID: 1503908

Abstract

Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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