Abstract
The effect of cancer cachexia on the oxidative metabolism of lipids has been studied in mice transplanted either with the MAC16 adenocarcinoma, which induces profound loss of body weight and depletion of lipid stores, or the MAC13 adenocarcinoma, which is the same histological type, but which grows without an effect on host body weight or lipid stores. While oxidation of D-[U-14C]glucose did not differ between animals bearing tumours of either type and non-tumour bearing controls, oxidation of [1-14C]triolein administered by intragastric intubation was significantly (P less than 0.05) higher in animals bearing the MAC16 tumour than in either non tumour-bearing controls or in animals bearing the MAC13 tumour. Intestinal absorption of [14C]lipid was significantly (P less than 0.05) reduced in animals bearing the MAC13 tumour when compared with either non tumour-bearing animals or MAC16 tumour-bearing animals, but was not significantly different in the latter two groups. The level of labelled lipids in heart and adipose tissue after an oral [14C]lipid load was significantly lower in animals bearing the MAC16 tumour compared with the other two groups. The level of tumour lipids was also higher in the MAC16 than in the MAC13 tumour after both an oral [14C]lipid load or by direct injection of [U-14C]palmitate complexed to albumin into epididymal fat pads. Oxidation of [U-14C]palmitate was also significantly enhanced in liver and heart homogenates from animals bearing the MAC16 tumour. These results suggest that in cachectic tumour-bearing animals mobilisation of body lipids is accompanied by an increased utilisation.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Argilés J. M., Lopez-Soriano F. J., Evans R. D., Williamson D. H. Interleukin-1 and lipid metabolism in the rat. Biochem J. 1989 May 1;259(3):673–678. doi: 10.1042/bj2590673. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beck S. A., Tisdale M. J. Lipid mobilising factors specifically associated with cancer cachexia. Br J Cancer. 1991 Jun;63(6):846–850. doi: 10.1038/bjc.1991.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beck S. A., Tisdale M. J. Production of lipolytic and proteolytic factors by a murine tumor-producing cachexia in the host. Cancer Res. 1987 Nov 15;47(22):5919–5923. [PubMed] [Google Scholar]
- Bibby M. C., Double J. A., Ali S. A., Fearon K. C., Brennan R. A., Tisdale M. J. Characterization of a transplantable adenocarcinoma of the mouse colon producing cachexia in recipient animals. J Natl Cancer Inst. 1987 Mar;78(3):539–546. [PubMed] [Google Scholar]
- Briddon S., Beck S. A., Tisdale M. J. Changes in activity of lipoprotein lipase, plasma free fatty acids and triglycerides with weight loss in a cachexia model. Cancer Lett. 1991 Apr;57(1):49–53. doi: 10.1016/0304-3835(91)90062-m. [DOI] [PubMed] [Google Scholar]
- Buzby G. P., Mullen J. L., Stein T. P., Miller E. E., Hobbs C. L., Rosato E. F. Host-tumor interaction and nutrient supply. Cancer. 1980 Jun 15;45(12):2940–2948. doi: 10.1002/1097-0142(19800615)45:12<2940::aid-cncr2820451208>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
- Devereux D. F., Redgrave T. G., Tilton M., Hollander D., Deckers P. J. Intolerance to administered lipids in tumor-bearing animals. Surgery. 1984 Aug;96(2):414–419. [PubMed] [Google Scholar]
- Evans R. D., Williamson D. H. Tissue-specific effects of rapid tumour growth on lipid metabolism in the rat during lactation and on litter removal. Biochem J. 1988 May 15;252(1):65–72. doi: 10.1042/bj2520065. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans R. D., Williamson D. H. Tumour necrosis factor alpha (cachectin) mimics some of the effects of tumour growth on the disposal of a [14C]lipid load in virgin, lactating and litter-removed rats. Biochem J. 1988 Dec 15;256(3):1055–1058. doi: 10.1042/bj2561055. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kitada S., Hays E. F., Mead J. F. Characterization of a lipid mobilizing factor from tumors. Prog Lipid Res. 1981;20:823–826. doi: 10.1016/0163-7827(81)90155-7. [DOI] [PubMed] [Google Scholar]
- Levinson M. R., Groeger J. S., Jeevanandam M., Brennan M. F. Free fatty acid turnover and lipolysis in septic mechanically ventilated cancer-bearing humans. Metabolism. 1988 Jul;37(7):618–625. doi: 10.1016/0026-0495(88)90078-9. [DOI] [PubMed] [Google Scholar]
- Lyon I., Ookhtens M., Montisano D., Baker N. Fat pad triacylglycerol fatty acid loss and oxidation as indices of total body triacylglycerol fatty acid mobilization and oxidation in starving mice. Biochim Biophys Acta. 1988 Feb 4;958(2):188–198. doi: 10.1016/0005-2760(88)90176-2. [DOI] [PubMed] [Google Scholar]
- Mahony S. M., Beck S. A., Tisdale M. J. Comparison of weight loss induced by recombinant tumour necrosis factor with that produced by a cachexia-inducing tumour. Br J Cancer. 1988 Apr;57(4):385–389. doi: 10.1038/bjc.1988.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Masuno H., Yamasaki N., Okuda H. Purification and characterization of a lipolytic factor (toxohormone-L) from cell-free fluid of ascites sarcoma 180. Cancer Res. 1981 Jan;41(1):284–288. [PubMed] [Google Scholar]
- Mulligan H. D., Tisdale M. J. Lipogenesis in tumour and host tissues in mice bearing colonic adenocarcinomas. Br J Cancer. 1991 May;63(5):719–722. doi: 10.1038/bjc.1991.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mulligan H. D., Tisdale M. J. Metabolic substrate utilization by tumour and host tissues in cancer cachexia. Biochem J. 1991 Jul 15;277(Pt 2):321–326. doi: 10.1042/bj2770321. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oller do Nascimento C. M., Williamson D. H. Evidence for conservation of dietary lipid in the rat during lactation and the immediate period after removal of the litter. Decreased oxidation of oral [1-14C]triolein. Biochem J. 1986 Oct 1;239(1):233–236. doi: 10.1042/bj2390233. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sauer L. A., Dauchy R. T. Blood nutrient concentrations and tumor growth in vivo in rats: relationships during the onset of an acute fast. Cancer Res. 1987 Feb 15;47(4):1065–1068. [PubMed] [Google Scholar]
- Sauer L. A., Dauchy R. T. Stimulation of tumor growth in adult rats in vivo during acute streptozotocin-induced diabetes. Cancer Res. 1987 Apr 1;47(7):1756–1761. [PubMed] [Google Scholar]
- Stansbie D., Brownsey R. W., Crettaz M., Denton R. M. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. Biochem J. 1976 Nov 15;160(2):413–416. doi: 10.1042/bj1600413. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tisdale M. J., Beck S. A. Inhibition of tumour-induced lipolysis in vitro and cachexia and tumour growth in vivo by eicosapentaenoic acid. Biochem Pharmacol. 1991 Jan 1;41(1):103–107. doi: 10.1016/0006-2952(91)90016-x. [DOI] [PubMed] [Google Scholar]
- WATERHOUSE C., NYE W. H. Metabolic effects of infused triglyceride. Metabolism. 1961 May;10:403–414. [PubMed] [Google Scholar]
- Warnold I., Lundholm K., Scherstén T. Energy balance and body composition in cancer patients. Cancer Res. 1978 Jun;38(6):1801–1807. [PubMed] [Google Scholar]