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. 1992 Nov;66(5):870–874. doi: 10.1038/bjc.1992.376

The influence of the host on the course of gastric carcinoma.

C W Janssen Jr 1, R T Lie 1, C F Bassøe 1, H Maartmann-Moe 1, R Matre 1
PMCID: PMC1977976  PMID: 1419630

Abstract

Immunoglobulins (Ig) and some complement components (C) were quantified in sera from patients with gastric carcinoma before surgery and at regular intervals during a 5-year follow-up. The preoperative concentrations of C1-INH and C4 were higher (P < 0.0005 and P < 0.005) and IgG lower (P < 0.0005) in 50 patients with recurrence than in 46 5-year survivors. The prognostic significant of C1-INH was superior to that of the extent of disease (F-values 37.1 and 26.1). The preoperative immune data classified 76% of the patients correctly as to recurrence and no recurrence. Also, the preoperative C1-INH concentration had a highly significant effect on time to recurrence of cancer (P = 0.0007), adjusting for age and disease extent. After surgery the mean IgG concentrations were within normal range and without difference between the two groups. On the other hand, the concentrations of C1-INH and C4 in the individual patients in both groups remained the same from before to after surgery and throughout the observation period (P = 0.34). Apparently, the serum levels of C1-INH and C4 do not reflect the bearing of cancer. We therefore suggest that these variables represent an independent immune state that is appropriate to the host. A comparison of our variables with those of healthy individuals seems to support this idea. This immune state has a significant influence on whether a resected gastric cancer will recur, and also on how soon recurrence may be manifest.

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Selected References

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  1. Gamel J., Seddon J., Polivogianis L., Albert D., Greenberg R. A method for assessing potential bias among cancer patients recorded as "dead of other causes." Application to cases of intraocular melanoma. Cancer. 1986 Jun 1;57(11):2246–2249. doi: 10.1002/1097-0142(19860601)57:11<2246::aid-cncr2820571130>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  2. Janssen C. W., Jr, Lie R. T., Maartmann-Moe H., Matre R. Serum C1-esterase inhibitor, an essential and independent prognosticator of gastric carcinoma. Br J Cancer. 1989 Oct;60(4):589–591. doi: 10.1038/bjc.1989.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Janssen C. W., Jr, Lie R. T., Maartmann-Moe H., Matre R. Who gets a second primary cancer after gastric cancer surgery? Eur J Surg Oncol. 1990 Jun;16(3):195–199. [PubMed] [Google Scholar]
  4. Janssen C. W., Jr, Maartmann-Moe H., Lie R. T. Concentrations of serum proteins and erythrocyte sedimentation rate in patients with different histological types of gastric carcinoma. Eur J Surg Oncol. 1987 Jun;13(3):207–211. [PubMed] [Google Scholar]
  5. Janssen C. W., Jr, Maartmann-Moe H., Lie R. T. Preoperative prediction of extent and prognosis of gastric carcinoma by four serum proteins and erythrocyte sedimentation rate. Eur J Surg Oncol. 1987 Aug;13(4):285–295. [PubMed] [Google Scholar]
  6. Janssen C. W., Jr, Tönder O., Matre R. Stage-related correlations between immunoglobulins and complement components in preoperative sera from patients with gastric carcinoma. Eur J Cancer Clin Oncol. 1983 Nov;19(11):1601–1605. doi: 10.1016/0277-5379(83)90092-5. [DOI] [PubMed] [Google Scholar]
  7. Janssen C. W., Jr, Tønder O., Matre R. Serum concentrations of immunoglobulins and complement components in patients with recurrence after resection of gastric carcinoma. Cancer Detect Prev. 1987;10(3-4):303–309. [PubMed] [Google Scholar]
  8. Osther K., Hojgaard K., Dybkjaer E. Demonstration of a complement of inactivator on cultured cells from human malignant brain tumours. Acta Neurol Scand. 1974;50(6):681–689. doi: 10.1111/j.1600-0404.1974.tb02814.x. [DOI] [PubMed] [Google Scholar]
  9. Osther K. Letter: C1 inactivation from cancer cells. Lancet. 1974 Mar 2;1(7853):359–360. doi: 10.1016/s0140-6736(74)93117-1. [DOI] [PubMed] [Google Scholar]
  10. Osther K., Linnemann R. Immunofluorescence measurement of C1 inactivator (alpha 2 neuraminoglycoprotein) activity of the surface of human carcinoma cells. Acta Pathol Microbiol Scand B Microbiol Immunol. 1973 Jun;81(3):365–372. doi: 10.1111/j.1699-0463.1973.tb02217.x. [DOI] [PubMed] [Google Scholar]
  11. Poste G., Fidler I. J. The pathogenesis of cancer metastasis. Nature. 1980 Jan 10;283(5743):139–146. doi: 10.1038/283139a0. [DOI] [PubMed] [Google Scholar]
  12. Shafir M., Bekesi J. G., Papatestas A., Slater G., Aufses A. H., Jr Preoperative and postoperative immunological evaluation of patients with colorectal cancer. Cancer. 1980 Aug 15;46(4):700–705. doi: 10.1002/1097-0142(19800815)46:4<700::aid-cncr2820460411>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  13. Tonder O., Thunold S. Receptors for immunoglobulin Fc in human malignant tissues. Scand J Immunol. 1973;2(3):207–215. doi: 10.1111/j.1365-3083.1973.tb02031.x. [DOI] [PubMed] [Google Scholar]
  14. Tönder O., Krishnan E. C., Jewell W. R., Morse P. A., Jr, Humphrey L. J. Tumor Fc receptors and tumor-associated immunoglobulins. Acta Pathol Microbiol Scand C. 1976 Apr;84(2):105–111. doi: 10.1111/j.1699-0463.1976.tb00006.x. [DOI] [PubMed] [Google Scholar]
  15. Woodruff M. The Walter Hubert Lecture, 1982. Interaction of cancer and host. Br J Cancer. 1982 Sep;46(3):313–322. doi: 10.1038/bjc.1982.206. [DOI] [PMC free article] [PubMed] [Google Scholar]

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