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. 1969 Mar 8;1(5644):595–598. doi: 10.1136/bmj.1.5644.595

Oral Glucose Tolerance and Related Factors in a Normal Population Sample—I. Blood Sugar, Plasma Insulin, Glyceride, and Cholesterol Measurements and the Effects of Age and Sex

D R Boyns, J N Crossley, M E Abrams, R J Jarrett, H Keen
PMCID: PMC1982424  PMID: 5766122

Abstract

Oral glucose tolerance tests were performed on 220 people, a representative sample of the employees of a large pharmaceutical company. Blood sugar and plasma immunoreactive insulin levels were measured on each sample of venous blood obtained before and at half-hourly intervals for two hours after 50 g. of glucose by mouth; plasma cholesterol and glycerides were measured on the fasting sample only.

Women had higher mean insulin levels throughout the test, though their mean blood sugar levels were higher only at 90 and 120 minutes. In both sexes there were positive correlations between age and the levels of blood sugar, plasma cholesterol, and plasma glycerides. Though the levels of glucose rose with age, those of insulin did not.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Block W. D., Jarrett K. J., Jr, Levine J. B. An improved automated determination of serum total cholesterol with a single color reagent. Clin Chem. 1966 Oct;12(10):681–689. [PubMed] [Google Scholar]
  2. Bowen A. J., Reeves R. L. Diurnal variation in glucose tolerance. Arch Intern Med. 1967 Mar;119(3):261–264. [PubMed] [Google Scholar]
  3. Buchanan K. D., McKiddie M. T. The normal insulin response to glucose. The relationship between blood sugar and plasma insulin. Diabetologia. 1967 Oct;3(5):460–464. doi: 10.1007/BF01228083. [DOI] [PubMed] [Google Scholar]
  4. Chlouverakis C., Jarrett R. J., Keen H. Glucose tolerance, age, and circulating insulin. Lancet. 1967 Apr 15;1(7494):806–809. doi: 10.1016/s0140-6736(67)92774-2. [DOI] [PubMed] [Google Scholar]
  5. Fredrickson D. S., Levy R. I., Lees R. S. Fat transport in lipoproteins--an integrated approach to mechanisms and disorders. N Engl J Med. 1967 Jan 19;276(3):148–contd. doi: 10.1056/NEJM196701192760305. [DOI] [PubMed] [Google Scholar]
  6. Hales C. N., Greenwood F. C., Mitchell F. L., Strauss W. T. Blood-glucose, plasma-insulin and growth hormone concentrations of individuals with minor abnormalities of glucose tolerance. Diabetologia. 1968 Mar;4(2):73–82. doi: 10.1007/BF01212536. [DOI] [PubMed] [Google Scholar]
  7. Keen H. Diabetes Survey in Bedford 1962. Proc R Soc Med. 1964 Mar;57(3):200–202. [PMC free article] [PubMed] [Google Scholar]
  8. LOFLAND H. B., Jr A SEMIAUTOMATED PROCEDURE FOR THE DETERMINATION OF TRIGLYCERIDES IN SERUM. Anal Biochem. 1964 Dec;9:393–400. doi: 10.1016/0003-2697(64)90199-x. [DOI] [PubMed] [Google Scholar]
  9. SCHAEFER L. E. SERUM CHOLESTEROL-TRIGLYCERIDE DISTRIBUTION IN A "NORMAL" NEW YORK CITY POPULATION. Am J Med. 1964 Feb;36:262–268. doi: 10.1016/0002-9343(64)90088-9. [DOI] [PubMed] [Google Scholar]
  10. SHARP C. L., BUTTERFIELD W. J., KEEN H. DIABETES SURVEY IN BEDFORD 1962. Proc R Soc Med. 1964 Mar;57:193–202. [PMC free article] [PubMed] [Google Scholar]
  11. Sheldon J., Taylor K. W. The immunoassay of insulin in human serum treated with sodium ethylene diamine tetra-acetate. J Endocrinol. 1965 Aug;33(1):157–158. doi: 10.1677/joe.0.0330157. [DOI] [PubMed] [Google Scholar]
  12. Welborn T. A., Rubenstein A. H., Haslam R., Fraser R. Normal insulin response to glucose. Lancet. 1966 Feb 5;1(7432):280–283. doi: 10.1016/s0140-6736(66)90637-4. [DOI] [PubMed] [Google Scholar]
  13. Whichelow M. J., Wigglesworth A., Cox B. D., Butterfield W. J., Abrams M. E. Critical analysis of blood sugar measurements in diabetes detection and diagnosis. Diabetes. 1967 Apr;16(4):219–226. doi: 10.2337/diab.16.4.219. [DOI] [PubMed] [Google Scholar]

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