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. 1969 Mar 8;1(5644):602–605. doi: 10.1136/bmj.1.5644.602

Effect of Oestrogens and Progestogens on Liver Function in the Puerperium

J Clinch, V R Tindall
PMCID: PMC1982437  PMID: 5766124

Abstract

A modified bromsulphthalein test has been used to detect alterations in liver function in puerperal women taking either a synthetic oestrogen, stilboestrol, or a pure progestogen, megestrol acetate. The oestrogen appreciably reduced the ability of the liver to excrete dye into the bile. It also reduced significantly the equivalent liver volume and the plasma clearance of dye. The progestogen did not have this effect. In so far as these results represent liver dysfunction they are due to the oestrogen component of the combined preparation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADLERCREUTZ H. ORAL CONTRACEPTIVES AND LIVER DAMAGE. Br Med J. 1964 Oct 31;2(5417):1133–1133. [PMC free article] [PubMed] [Google Scholar]
  2. BARBER-RILEY G., GOETZEE A. E., RICHARDS T. G., THOMSON J. Y. The transfer of bromsulphthalein from the plasma to the bile in man. Clin Sci. 1961 Apr;20:149–159. [PubMed] [Google Scholar]
  3. Brown J. B., Blair H. A. Urinary OEstrogen Metabolites of 19-Norethisterone and its Esters [Summary]. Proc R Soc Med. 1960 Jun;53(6):433–433. doi: 10.1177/003591576005300611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Burton J. L. Effect of oral contraceptives on haemoglobin, packed-cell volume, serum-iron, and total iron-binding capacity in healthy women. Lancet. 1967 May 6;1(7497):978–980. doi: 10.1016/s0140-6736(67)92359-8. [DOI] [PubMed] [Google Scholar]
  5. Burton J. L., Loudon N. B., Wilson A. T. Urinary coproporphyrin excretion and hepatic function in women taking oral contraceptives. Lancet. 1967 Dec 23;2(7530):1326–1327. doi: 10.1016/s0140-6736(67)90912-9. [DOI] [PubMed] [Google Scholar]
  6. Cooke B. A., Vallance D. K. Metabolism of megestrol acetate and related progesterone analogues by liver preparations in vitro. Biochem J. 1965 Dec;97(3):672–677. doi: 10.1042/bj0970672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cooper J. M., Kellie A. E. The metabolism of megestrol acetate (17-alpha-acetoxy-6-methylpregna-4,6-diene-3,20-dione) in women. Steroids. 1968 Feb;11(2):133–149. doi: 10.1016/0039-128x(68)90004-4. [DOI] [PubMed] [Google Scholar]
  8. DORAN T. A., HARKINS J. L., GORNALL A. G., THOMPSON D. W. CLINICAL AND LABORATORY ASSESSMENT OF A NEW PROGESTATIONAL AGENT. Can Med Assoc J. 1964 Oct 24;91:900–907. [PMC free article] [PubMed] [Google Scholar]
  9. Daniel D. G., Bloom A. L., Giddings J. C., Campbell H., Turnbull A. C. Increased factor IX levels in puerperium during administration of diethylstilboestrol. Br Med J. 1968 Mar 30;1(5595):801–803. doi: 10.1136/bmj.1.5595.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. EISALO A., JAERVINEN P. A., LUUKKAINEN T. HEPATIC IMPAIRMENT DURING THE INTAKE OF CONTRACEPTIVE PILLS: CLINICAL TRIAL WITH POSTMENOPAUSAL WOMEN. Br Med J. 1964 Aug 15;2(5406):426–427. doi: 10.1136/bmj.2.5406.426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KLEINER G. J., KRESCH L., ARIAS I. M. STUDIES ON HEPATIC EXCRETARY FUNCTION. II. THE EFFECT OF NORETHYNODREL AND MESTRANOL ON BROMSULFALIEN SODIUM METABOLISM IN WOMEN OF CHILDBEARING AGE. N Engl J Med. 1965 Aug 19;273:420–423. doi: 10.1056/NEJM196508192730804. [DOI] [PubMed] [Google Scholar]
  12. MUELLER M. N., KAPPAS A. ESTROGEN PHARMACOLOGY. I. THE INFLUENCE OF ESTRADIOL AND ESTRIOL ON HEPATIC DISPOSAL OF SULFOBROMOPHTHALEIN (BSP) IN MAN. J Clin Invest. 1964 Oct;43:1905–1914. doi: 10.1172/JCI105064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Martinez-Manautou J., Giner-Velasquez J., Cortes-Gallegos V., Aznar R., Rojas B., Guitterez-Najar A., Rudel H. W. Daily progestogen for contraception: a clinical study. Br Med J. 1967 Jun 17;2(5554):730–732. doi: 10.1136/bmj.2.5554.730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. PAULSEN C. A., LEACH R. B., LANMAN J., GOLDSTON N., MADDOCK W. O., HELLER C. G. Inherent estrogenicity of norethindrone and norethynodrel: comparison with other synthetic progestins and progesterone. J Clin Endocrinol Metab. 1962 Oct;22:1033–1039. doi: 10.1210/jcem-22-10-1033. [DOI] [PubMed] [Google Scholar]
  15. Robertson G. S. Serum protein and cholinesterase changes in association with contraceptive pills. Lancet. 1967 Feb 4;1(7484):232–235. doi: 10.1016/s0140-6736(67)91298-6. [DOI] [PubMed] [Google Scholar]
  16. Svanborg A., Vikrot O. Plasma lipid fractions, including individual phospholipids, at various stages of pregnancy. Acta Med Scand. 1965 Nov;178(5):615–630. doi: 10.1111/j.0954-6820.1965.tb04310.x. [DOI] [PubMed] [Google Scholar]
  17. Tindall V. R., Beazley J. M. An assessment of changes in liver function during normal pregnancy--using a modified bromsulphthalein test. J Obstet Gynaecol Br Commonw. 1965 Oct;72(5):717–737. doi: 10.1111/j.1471-0528.1965.tb00090.x. [DOI] [PubMed] [Google Scholar]
  18. Wynn J. W., Doar J. W., Mills G. L. Some effects of oral contraceptives on serum-lipid and lipoprotein levels. Lancet. 1966 Oct 1;2(7466):720–723. doi: 10.1016/s0140-6736(66)92979-5. [DOI] [PubMed] [Google Scholar]
  19. Wynn V., Doar J. W. Some effects of oral contraceptives on carbohydrate metabolism. Lancet. 1966 Oct 1;2(7466):715–719. doi: 10.1016/s0140-6736(66)92978-3. [DOI] [PubMed] [Google Scholar]
  20. Zañartu J., Rodriguez-Moore G., Pupkin M., Salas O., Guerrero R. Antifertility effect of continuous low-dosage oral progestogen therapy. Br Med J. 1968 May 4;2(5600):263–266. doi: 10.1136/bmj.2.5600.263. [DOI] [PMC free article] [PubMed] [Google Scholar]

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