Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1969 Feb 8;1(5640):357–358. doi: 10.1136/bmj.1.5640.357

Comparison of Preseasonal and Coseasonal Allpyral with Depo-Medrone in Summer Hay-fever

M A Ganderton, Jonathan Brostoff, A W Frankland
PMCID: PMC1982610  PMID: 4883848

Abstract

Three hundred patients with grass pollen hay-fever, with or without pollen asthma, were given one of three forms of treatment: preseasonal or coseasonal alum-precipitated pyridine extracted grass pollen (Allpyral) or methylprednisolone acetate in slow-release form (Depo-Medrone). Significant improvement was obtained with preseasonal Allpyral and with Depo-Medrone, but the degree of improvement obtained with coseasonal Allpyral fell within the limits of placebo response.

Nevertheless, it is considered that the definite suppression of the pituitary-adrenal function which results from the use of a long-term steroid is not justified in a benign condition such as hay-fever.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARBEITER H. I., KNAPP R. D., Jr Allergic rhinitis and bronchial asthma--treatment with parenteral methylprednisolone acetate. Ann Allergy. 1961 Jun;19:633–636. [PubMed] [Google Scholar]
  2. BROWN E. A. The treatment of allergy to ragweed pollen by means of a single annual injection of emulsified pollen extract. VI. Discussion of results, relationships and some miscellaneous factors. Ann Allergy. 1959 May-Jun;17(3):358–379. [PubMed] [Google Scholar]
  3. Bain L. S., Balch H. W., Jacomb R. G. Parenteral administration of 6-alpha-methylprednisolone-21- acetate. I. Intra-articular injection: comparison with hydrocortisone acetate. Ann Phys Med. 1967 May;9(2):43–48. [PubMed] [Google Scholar]
  4. Evans R. G. Corticosteroid therapy in allergic conditions. Practitioner. 1966 Jun;196(176):781–787. [PubMed] [Google Scholar]
  5. FRANKLAND A. W., AUGUSTIN R. Prophylaxis of summer hay-fever and asthma: a controlled trial comparing crude grass-pollen extracts with the isolated main protein component. Lancet. 1954 May 22;266(6821):1055–1057. doi: 10.1016/s0140-6736(54)91620-7. [DOI] [PubMed] [Google Scholar]
  6. Frankland A. W., Noelpp B. Summer hay fever treated with aqueous and alum-precipitated pyridine extracts. Practitioner. 1966 Jun;196(176):766–770. [PubMed] [Google Scholar]
  7. Frankland A. W. Preseasonal injection treatment in hay fever using aqueous extracts. Int Arch Allergy Appl Immunol. 1965;28(1):1–11. doi: 10.1159/000229629. [DOI] [PubMed] [Google Scholar]
  8. Harris M. C. HAY FEVER-A Comparative Clinical Evaluation of Treatment with Aqueous Pollen Extracts, Alum-Precipitated Pyridine Pollen Extracts and Aqueous Pollen in Oil Emulsions. Calif Med. 1962 Nov;97(5):286–290. [PMC free article] [PubMed] [Google Scholar]
  9. LANDON J., WYNN V., JAMES V. H. THE ADRENOCORTICAL RESPONSE TO INSULIN-INDUCED HYPOGLYCAEMIA. J Endocrinol. 1963 Nov;27:183–192. doi: 10.1677/joe.0.0270183. [DOI] [PubMed] [Google Scholar]
  10. Pearson R. S. Depot Injections in Treatment of Hay-fever and Pollen Asthma. Br Med J. 1965 Nov 13;2(5471):1148–1152. doi: 10.1136/bmj.2.5471.1148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. TREADWELL B. L., SALVAGE O., SEVER E. D., COPEMAN W. S. Pituitary-adrenal function during corticosteroid therapy. Lancet. 1963 Feb 16;1(7277):355–358. doi: 10.1016/s0140-6736(63)91383-7. [DOI] [PubMed] [Google Scholar]
  12. WOOD J. B., FRANKLAND A. W., JAMES V. H., LANDON J. A RAPID TEST OF ADRENOCORTICAL FUNCTION. Lancet. 1965 Jan 30;1(7379):243–245. doi: 10.1016/s0140-6736(65)91526-6. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES