Skip to main content
British Medical Journal logoLink to British Medical Journal
. 1969 Mar 22;1(5646):753–756. doi: 10.1136/bmj.1.5646.753

Hypophosphataemia in Septicaemia: Higher Incidence in Gram-negative Than in Gram-positive Infections

G F Riedler, W A Scheitlin
PMCID: PMC1982839  PMID: 4890205

Abstract

Phosphataemia has been investigated in 54 patients with Gram-negative septicaemias; either absolute (serum phosphate <2 mg./100 ml.) or relative (P./B.U.N. 0·04) hypophosphataemia was found in 69% of all determinations. In 37 patients with Gram-positive septicaemias hypophosphataemia was present in only 24%, many of whom had additional Gram-negative bacteriuria and possible Gram-negative septicaemia suppressed by antibiotics. The mechanism of this phenomenon is not known. This new sign of Gram-negative septicaemia has some diagnostic importance.

Full text

PDF
753

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson R. W., James P. M., Bredenberg C. E., Hardaway R. M. Phenoxybenzamine in septic shock. Ann Surg. 1967 Mar;165(3):341–350. doi: 10.1097/00000658-196703000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COHEN B. D. Abnormal carbohydrate metabolism in renal disease. Blood glucose unresponsiveness to hypoglycemia, epinephrine, and glucagon. Ann Intern Med. 1962 Aug;57:204–213. doi: 10.7326/0003-4819-57-2-204. [DOI] [PubMed] [Google Scholar]
  3. DOOLAN P. D., WIGGINS R. A., THIEL G. B., LEE K. J., MARTINEZ E. Acute renal insufficiency following aortic surgery: a discussion of the pathogenesis and a consideration of gangrene of an extremity as a complication. Am J Med. 1960 Jun;28:895–904. doi: 10.1016/0002-9343(60)90198-4. [DOI] [PubMed] [Google Scholar]
  4. FROESCH E. R., WOLF H. P., BAITSCH H., PRADER A., LABHART A. Hereditary fructose intolerance. An inborn defect of hepatic fructose-1-phosphate splitting aldolase. Am J Med. 1963 Feb;34:151–167. doi: 10.1016/0002-9343(63)90050-0. [DOI] [PubMed] [Google Scholar]
  5. GEORGE W. K., GEORGE W. D., Jr, SMITH J. P., GORDON F. T., BAIRD E. E., MILLS G. C. CHANGES IN SERUM CALCIUM, SERUM PHOSPHATE AND RED-CELL PHOSPHATE DURING HYPERVENTILATION. N Engl J Med. 1964 Apr 2;270:726–728. doi: 10.1056/NEJM196404022701407. [DOI] [PubMed] [Google Scholar]
  6. Hodgin U. G., Sanford J. P. Gram-negative rod bacteremia. An analysis of 100 patients. Am J Med. 1965 Dec;39(6):952–960. doi: 10.1016/0002-9343(65)90118-x. [DOI] [PubMed] [Google Scholar]
  7. MACLEAN L. D., SPINK W. W., VISSCHER M. B., WEIL M. H. Studies on the circulatory changes in the dog produced by endotoxin from gram-negative microorganisms. J Clin Invest. 1956 Nov;35(11):1191–1198. doi: 10.1172/JCI103373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MOSTELLAR M. E., TUTTLE E. P., Jr EFFECTS OF ALKALOSIS ON PLASMA CONCENTRATION AND URINARY EXCRETION OF INORGANIC PHOSPHATE IN MAN. J Clin Invest. 1964 Jan;43:138–149. doi: 10.1172/JCI104888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McGehee W. G., Rapaport S. I., Hjort P. F. Intravascular coagulation in fulminant meningococcemia. Ann Intern Med. 1967 Aug;67(2):250–260. doi: 10.7326/0003-4819-67-2-250. [DOI] [PubMed] [Google Scholar]
  10. OECHSLIN R., SCHEITLIN W., FRICK P. [Shock states in sepsis with gram-negative pathogens]. Schweiz Med Wochenschr. 1962 Sep 22;92:1151–1155. [PubMed] [Google Scholar]
  11. ROBIN E. D., DAVIS R. P., REES S. B. Salicylate intoxication with special reference to the development of hypokalemia. Am J Med. 1959 Jun;26(6):869–882. doi: 10.1016/0002-9343(59)90209-8. [DOI] [PubMed] [Google Scholar]
  12. Rosner F., Ritz N. D. The defibrination syndrome. Arch Intern Med. 1966 Jan;117(1):17–24. [PubMed] [Google Scholar]
  13. SALTZMAN H. A., HEYMAN A., SIEKER H. O. Correlation of clinical and physiologic manifestations of sustained hyperventilation. N Engl J Med. 1963 Jun 27;268:1431–1436. doi: 10.1056/NEJM196306272682602. [DOI] [PubMed] [Google Scholar]
  14. SPINK W. W. Endotoxin shock. Ann Intern Med. 1962 Oct;57:538–552. doi: 10.7326/0003-4819-57-4-538. [DOI] [PubMed] [Google Scholar]
  15. Strauch M., McLaughlin J. S., Mansberger A., Young J., Mendonca P., Gray K., Cowley R. A. Effects of septic shock on renal function in humans. Ann Surg. 1967 Apr;165(4):536–543. doi: 10.1097/00000658-196704000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. WAISBREN B. A. GRAM-NEGATIVE SHOCK AND ENDOTOXIN SHOCK. Am J Med. 1964 Jun;36:819–824. doi: 10.1016/0002-9343(64)90111-1. [DOI] [PubMed] [Google Scholar]
  17. WEIL M. H., SHUBIN H., BIDDLE M. SHOCK CAUSED BY GRAM-NEGATIVE MICROORGANISMS. ANALYSIS OF 169 CASES. Ann Intern Med. 1964 Mar;60:384–400. doi: 10.7326/0003-4819-60-3-384. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES