Abstract
An inflammatory exudate collected from a site of major surgery (partial gastrectomy) was found to possess definite anti-inflammatory properties when tested by the carrageenin oedema technique (a method widely adopted for the assessment of potential anti-rheumatic agents). Such anti-inflammatory properties could not be detected in the serum of normal healthy adults or in an abdominal asdtes fluid. The active component in the exudate showed several properties in common with a similar anti-inflammatory substance present in inflammatory exudates of animal origin.
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- DIPASQUALE G., GIRERD R. J. Anti-inflammatory properties of lyophilized inflammatory exudates. Am J Physiol. 1961 Dec;201:1155–1158. doi: 10.1152/ajplegacy.1961.201.6.1155. [DOI] [PubMed] [Google Scholar]
- DIPASQUALE G., GIRERD R. J., BEACH V. L., STEINETZ B. G. ANTIPHLOGISTIC ACTION OF GRANULOMA POUCH EXUDATES IN INTACT OR ADRENALECTOMIZED RATS. Am J Physiol. 1963 Dec;205:1080–1082. doi: 10.1152/ajplegacy.1963.205.6.1080. [DOI] [PubMed] [Google Scholar]
- ROBINSON B. V., ROBSON J. M. PRODUCTION OF AN ANTI-INFLAMMATORY SUBSTANCE AT A SITE OF INFLAMMATION. Br J Pharmacol Chemother. 1964 Oct;23:420–432. doi: 10.1111/j.1476-5381.1964.tb01598.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robinson B. V., Robson J. M. Further studies on the anti-inflammatory factor found at a site of inflammation. Br J Pharmacol Chemother. 1966 Feb;26(2):372–384. doi: 10.1111/j.1476-5381.1966.tb01917.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WINTER C. A., RISLEY E. A., NUSS G. W. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med. 1962 Dec;111:544–547. doi: 10.3181/00379727-111-27849. [DOI] [PubMed] [Google Scholar]
- Werner M., Odenthal D. Serum protein changes after gastrectomy as a model of acute phase reaction. J Lab Clin Med. 1967 Aug;70(2):302–310. [PubMed] [Google Scholar]