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. 1969 Apr 5;2(5648):13–15. doi: 10.1136/bmj.2.5648.13

Weight-reducing Effect of Diguanides in Obese Non-diabetic Women

J F Munro, A C MacCuish, A Marshall, Elizabeth M Wilson, L J P Duncan
PMCID: PMC1983008  PMID: 4887385

Abstract

A double-blind trial was carried out to assess the weight-reducing effect of the diguanides in 90 women with refractory obesity and normal oral glucose tolerance. The daily dosage of phenformin and metformin was increased at weekly intervals up to 300 mg. and 3 g. respectively, and patients were maintained at this dose or on the maximum they could tolerate without anorexia or other gastrointestinal side-effects. Seventy-seven completed the 16-week period of study. There was a statistically significant difference between the mean weight change of the control and the treated groups, but no difference between those treated by phenformin or metformin. The weight-losing influence of the diguanides appeared to be no longer significant after the twelfth week of treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Butterfield W. J., Whichelow M. J. Effect of diet, sulphonylureas, and phenformin on peripheral glucose uptake in diabetes and obesity. Lancet. 1968 Oct 12;2(7572):785–788. doi: 10.1016/s0140-6736(68)92452-5. [DOI] [PubMed] [Google Scholar]
  2. Clarke B. F., Duncan L. J. Comparison of chlorpropamide and metformin treatment on weight and blood-glucose response of uncontrolled obese diabetics. Lancet. 1968 Jan 20;1(7534):123–126. doi: 10.1016/s0140-6736(68)92726-8. [DOI] [PubMed] [Google Scholar]
  3. Czyzyk A., Tawecki J., Sadowski J., Ponikowska I., Szczepanik Z. Effect of biguanides on intestinal absorption of glucose. Diabetes. 1968 Aug;17(8):492–498. doi: 10.2337/diab.17.8.492. [DOI] [PubMed] [Google Scholar]
  4. DUNCAN L. J., ROSE K., MEIKLEJOHN A. P. Phenmetrazine hydrochloride and methylcellulose in the treatment of "refractory" obesity. Lancet. 1960 Jun 11;1(7137):1262–1265. doi: 10.1016/s0140-6736(60)92249-2. [DOI] [PubMed] [Google Scholar]
  5. Kreisberg R. A. Glucose metabolism in normal and obese subjects. Effect of phenformin. Diabetes. 1968 Aug;17(8):481–488. doi: 10.2337/diab.17.8.481. [DOI] [PubMed] [Google Scholar]
  6. Munro J. F., Seaton D. A., Duncan L. J. Treatment of refractory obesity with fenfluramine. Br Med J. 1966 Sep 10;2(5514):624–625. doi: 10.1136/bmj.2.5514.624. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Pedersen J., Olesen E. S. Observations on the mechanism of increased weight loss during metformin administration in obesity. Acta Endocrinol (Copenh) 1968 Apr;57(4):683–688. doi: 10.1530/acta.0.0570683. [DOI] [PubMed] [Google Scholar]
  8. Proctor D. W., Stowers J. M. Fatal lactic acidosis after an overdose of phenformin. Br Med J. 1967 Oct 28;4(5573):216–216. doi: 10.1136/bmj.4.5573.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Roginsky M. S., Sandler J. Phenformin in human obesity. Ann N Y Acad Sci. 1968 Mar 26;148(3):892–896. doi: 10.1111/j.1749-6632.1968.tb27763.x. [DOI] [PubMed] [Google Scholar]
  10. SEATON D. A., DUNCAN L. J., ROSE K., SCOTT A. M. Diethyl-propion in the treatment of "refractory" obesity. Br Med J. 1961 Apr 8;1(5231):1009–1011. doi: 10.1136/bmj.1.5231.1009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SEATON D. A., ROSE K., DUNCAN L. J. A COMPARISON OF THE APPETITE SUPPRESSING PROPERTIES OF DEXAMPHETAMINE AND PHENTERMINE. Scott Med J. 1964 Nov;9:482–485. doi: 10.1177/003693306400901104. [DOI] [PubMed] [Google Scholar]
  12. SEATON D. A., ROSE K., DUNCAN L. J. CURRENT THERAPEUTICS. 203. SUSTAINED-ACTION CHLORPHENTERMINE IN THE CORRECTION OF REFRACTORY OBESITY. Practitioner. 1964 Nov;193:698–702. [PubMed] [Google Scholar]
  13. Searle G. L., Cavalieri R. R. Glucose kinetics before and after phenformin in the human subject. Ann N Y Acad Sci. 1968 Mar 26;148(3):734–742. doi: 10.1111/j.1749-6632.1968.tb27745.x. [DOI] [PubMed] [Google Scholar]
  14. TRANQUADA R. E., BERNSTEIN S., MARTIN H. E. Irreversible lactic acidosis associated with phenformine therapy. Report of three cases. JAMA. 1963 Apr 6;184:37–42. doi: 10.1001/jama.1963.03700140093013. [DOI] [PubMed] [Google Scholar]
  15. YOUNG J. M., ARMANINO L. P. LACTIC ACIDOSIS AND PHENFORMIN INTOXICATION. REPORT OF TWO CASES WITH REVIEW OF LITERATURE. Calif Med. 1965 Sep;103:198–202. [PMC free article] [PubMed] [Google Scholar]

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