Abstract
Study of the effect of phenformin on the blood glucose level in normal subjects before and during 70 hours of starvation showed a statistically significant hypoglycaemic effect after 40 hours of starvation. This effect was not due to increased glucose utilization.
Another finding in this study was a statistically significant decrease in total urinary nitrogen excretion during starvation in subjects given phenformin. These findings show that the hypoglycaemic effect of phenformin in starved normal subjects is due to inhibition of gluconeogenesis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Altschuld R. A., Kruger F. A. Inhibition of hepatic gluconeogenesis in guinea pig by phenformin. Ann N Y Acad Sci. 1968 Mar 26;148(3):612–622. doi: 10.1111/j.1749-6632.1968.tb27735.x. [DOI] [PubMed] [Google Scholar]
- Christensen N. J. Notes on the glucose oxidase method. Scand J Clin Lab Invest. 1967;19(4):379–384. doi: 10.3109/00365516709090653. [DOI] [PubMed] [Google Scholar]
- FAJANS S. S., MOORHOUSE J. A., DOORENBOS H., LOUIS L. H., CONN J. W. Metabolic effects of phenethylbiguanide in normal subjects and in diabetic patients. Diabetes. 1960 May-Jun;9:194–201. doi: 10.2337/diab.9.3.194. [DOI] [PubMed] [Google Scholar]
- Kreisberg R. A. Kinetics of glucose utilization in obesity: the effect of phenformin. Ann N Y Acad Sci. 1968 Mar 26;148(3):743–755. doi: 10.1111/j.1749-6632.1968.tb27746.x. [DOI] [PubMed] [Google Scholar]
- LUNDBAEK K. Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus. Br Med J. 1962 Jun 2;1(5291):1507–1513. doi: 10.1136/bmj.1.5291.1507. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MADISON L. L., UNGER R. H. Effect of phenoformin on peripheral glucose utilization in human diabetic and nondiabetic subjects. Diabetes. 1960 May-Jun;9:202–206. doi: 10.2337/diab.9.3.202. [DOI] [PubMed] [Google Scholar]
- Meyer F., Ipaktchi M., Clauser H. Specific inhibition of gluconeogenesis by biguanides. Nature. 1967 Jan 14;213(5072):203–204. doi: 10.1038/213203a0. [DOI] [PubMed] [Google Scholar]
- Searle G. L., Schilling S., Porte D., Barbaccia J., De Grazia J., Cavalieri R. R. Body glucose kinetics in nondiabetic human subjects after phenethylbiguanide. Diabetes. 1966 Mar;15(3):173–178. doi: 10.2337/diab.15.3.173. [DOI] [PubMed] [Google Scholar]
- WILLIAMS R. H., TYBERGHEIN J. M., HYDE P. M., NIELSEN R. L. Studies related to the hypoglycemic action of phenethyldiguanide. Metabolism. 1957 Jul;6(4):311–319. [PubMed] [Google Scholar]