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. 1969 May 3;2(5652):276–279. doi: 10.1136/bmj.2.5652.276

Role of Acidosis in Renal Osteomalacia

M Cochran, B E C Nordin
PMCID: PMC1983146  PMID: 5780454

Abstract

Of nine patients with uraemic osteomalacia, the underlying renal lesion was pyelonephritis in seven. All of the patients were characterized by impairment of acidifying power and severe metabolic acidosis. It is suggested that metabolic acidosis may be a definite factor in the pathogenesis of uraemic osteomalacia, possibly by reducing the proportion of trivalent phosphate in the plasma and/or by reducing plasma calcium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cochran M., Peacock M., Smith D. A., Nordin B. E. Renal tubular acidosis of pyelonephritis with renal stone disease. Br Med J. 1968 Jun 22;2(5607):721–729. doi: 10.1136/bmj.2.5607.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Garner A., Ball J. Quantitative observations on mineralised and unmineralised bone in chronic renal azotaemia and intestinal malabsorption syndrome. J Pathol Bacteriol. 1966 Apr;91(2):545–561. doi: 10.1002/path.1700910231. [DOI] [PubMed] [Google Scholar]
  3. Lemann J., Litzow J. R., Lennon E. J. Studies of the mechanism by which chronic metabolic acidosis augments urinary calcium excretion in man. J Clin Invest. 1967 Aug;46(8):1318–1328. doi: 10.1172/JCI105624. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Litzow J. R., Lemann J., Jr, Lennon E. J. The effect of treatment of acidosis on calcium balance in patients with chronic azotemic renal disease. J Clin Invest. 1967 Feb;46(2):280–286. doi: 10.1172/JCI105530. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Morgan D. B., Stanley J., Fourman P. The mineral deficit in osteomalacic bone. Clin Sci. 1968 Oct;35(2):337–345. [PubMed] [Google Scholar]
  6. NORDIN B. E. The estimation of "free" calcium in the urine and its relevance to calculus formation. Br J Urol. 1959 Dec;31:404–413. doi: 10.1111/j.1464-410x.1959.tb09439.x. [DOI] [PubMed] [Google Scholar]
  7. Nordin B. E., Bulusu L. A modified index of phosphate excretion. Postgrad Med J. 1968 Jan;44(507):93–97. doi: 10.1136/pgmj.44.507.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Peacock M., Knowles F., Nordin B. E. Effect of calcium administration and deprivation on serum and urine calcium in stone-forming and control subjects. Br Med J. 1968 Jun 22;2(5607):729–731. doi: 10.1136/bmj.2.5607.729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pellegrino E. D., Biltz R. M. The composition of human bone in uremia. Observations on the reservoir functions of bone and demonstration of a labile fraction of bone carbonate. Medicine (Baltimore) 1965 Sep;44(5):397–418. doi: 10.1097/00005792-196509000-00002. [DOI] [PubMed] [Google Scholar]
  10. STANBURY S. W., LUMB G. A. Metabolic studies of renal osteodystrophy. I. Calcium, phosphorus and nitrogen metabolism in rickets, osteomalacia and hyperparathyroidism complicating chronic uremia and in the osteomalacia of the adult Fanconi syndrome. Medicine (Baltimore) 1962 Feb;41:1–34. [PubMed] [Google Scholar]
  11. Stanbury S. W., Lumb G. A. Parathyroid function in chronic renal failure. A statistical survey of the plasma biochemistry in azotaemic renal osteodystrophy. Q J Med. 1966 Jan;35(137):1–23. [PubMed] [Google Scholar]
  12. YENDT E. R., HOWARD J. E. Studies on the mode of action of citrate therapy in rickets. Bull Johns Hopkins Hosp. 1955 Mar;96(3):101–115. [PubMed] [Google Scholar]

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