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. 1969 May 10;2(5653):346–348. doi: 10.1136/bmj.2.5653.346

Serum Growth Hormone Levels and the Response of Diabetic Retinopathy to Pituitary Ablation*

A D Wright, E M Kohner, N W Oakley, M Hartog, G F Joplin, T Russell Fraser
PMCID: PMC1983255  PMID: 5768460

Abstract

Serum growth hormone levels were measured during insulin tolerance tests in 36 patients after yttrium-90 pituitary implantation for diabetic retinopathy. The response of the new blood vessels was more clearly related to loss of growth hormone function than was the improvement of retinal haemorrhages and microaneurysms. The overall response of the retinopathy was greatest when growth hormone function was lost.

Since the loss of growth hormone function was related to the loss of other aspects of anterior pituitary function, a unique role of growth hormone in the response of diabetic retinopathy to pituitary ablation could not be established.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FIELD R. A., SCHEPENS C. L., SWEET W. H., APPELS A. The effect of hypophyseal stalk section on advancing diabetic retinopathy. Report of thirteen cases. Diabetes. 1962 Nov-Dec;11:465–469. [PubMed] [Google Scholar]
  2. Fankhauser S., Teuscher A., König H., Reubi F. Hypophysectomy for the treatment of advanced diabetic retinopathy. Helv Med Acta. 1966 Apr;33(1):22–28. [PubMed] [Google Scholar]
  3. Fraser R., Wright A. D. Standard procedures for assessing hypersecretion or secretory capacity for human growth hormone, using the radioimmunoassay. Postgrad Med J. 1968 Jan;44(507):53–58. doi: 10.1136/pgmj.44.507.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GRAEF I., MAIER H. C. Observations on the influence of adrenalectomy on diabetic retinopathy. Diabetes. 1962 Nov-Dec;11:485–490. [PubMed] [Google Scholar]
  5. HARTOG M., GAAFAR M. A., MEISSER B., FRASER R. IMMUNOASSAY OF SERUM GROWTH HORMONE IN ACROMEGALIC PATIENTS. Br Med J. 1964 Nov 14;2(5419):1229–1232. doi: 10.1136/bmj.2.5419.1229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Joplin G. F., Fraser R., Hill D. W., Oakley N. W., Scott D. J., Doyle Pituitary ablation for diabetic retinopathy. Q J Med. 1965 Oct;34(136):443–462. [PubMed] [Google Scholar]
  7. Joplin G. F., Oakley N. W., Hill D. W., Kohner E. M., Fraser T. R. Diabetic retinopathy. II. Comparison of disease remission induced by various degrees of pituitary ablation by Y90. Diabetologia. 1967 Aug;3(4):406–412. doi: 10.1007/BF02342634. [DOI] [PubMed] [Google Scholar]
  8. LUFT R. The use of hypophysectomy in juvenile diabetes mellitus with vascular complications. Diabetes. 1962 Nov-Dec;11:461–462. [PubMed] [Google Scholar]
  9. Oakley N., Hill D. W., Joplin G. F., Kohner E. M., Fraser T. R. Diabetic retinopathy. I. The assessment of severity and progress by comparison with a set of standard fundus photographs. Diabetologia. 1967 Aug;3(4):402–405. doi: 10.1007/BF02342633. [DOI] [PubMed] [Google Scholar]
  10. Powell E. D., Frantz A. G., Rabkin M. T., Field R. A. Growth hormone in relation to diabetic retinopathy. N Engl J Med. 1966 Oct 27;275(17):922–925. doi: 10.1056/NEJM196610272751703. [DOI] [PubMed] [Google Scholar]
  11. Ray B. S., Pazianos A. G., Greenberg E., Peretz W. L., McLean J. M. Pituitary ablation for diabetic retinopathy. I. Results of hypophysectomy. (A ten-year evaluation). JAMA. 1968 Jan 8;203(2):79–84. [PubMed] [Google Scholar]
  12. Teuscher A., Fankhauser S., Girard J., Wyss F. The significance of endocrine activity in hypophysectomized diabetics. Helv Med Acta. 1966 Apr;33(1):29–35. [PubMed] [Google Scholar]

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