Abstract
Long-term follow up of 57 young adults with coeliac disease diagnosed in childhood showed that 13 had relapsed clinically and had resumed a gluten-free diet Of the remainder, who were taking a normal diet and were apparently normal, 19 had low serum folate levels and 11 low serum iron levels. Pregnancy was found particularly likely to provoke an overt relapse.
Only six patients were found to be stunted in height, while the menarche had occurred within the average range. The study also confirmed the very low present-daymortality rate of coeliac disease in childhood, which at the Hospital for Sick Children in London has been 0·4% between 1951 and 1968. In view of the finding that childhood coeliac disease usually persists, even though not causing symptoms, it is suggested that the use of a gluten-free diet should be lifelong.
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Selected References
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- BADENOCH J., CALLENDER S. T. Iron metabolism in steatorrhea; the use of radioactive iron in studies of absorption and utilization. Blood. 1954 Feb;9(2):123–133. [PubMed] [Google Scholar]
- BOTHWELL T. H., MALLETT B. The determination of iron in plasma or serum. Biochem J. 1955 Apr;59(4):599–602. doi: 10.1042/bj0590599. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COOKE W. T., FONE D. J., COX E. V., MEYNELL M. J., GADDIE R. ADULT COELIAC DISEASE. Gut. 1963 Sep;4:279–291. doi: 10.1136/gut.4.3.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRENCH J. M., HAWKINS C. F., SMITH N. The effect of a wheat-gluten-free diet in adult idiopathic steatorrhoea; a study of 22 cases. Q J Med. 1957 Oct;26(104):481–499. [PubMed] [Google Scholar]
- GOUGH K. R., READ A. E., NAISH J. M. Intestinal reticulosis as a complication of idiopathic steatorrhoea. Gut. 1962 Sep;3:232–239. doi: 10.1136/gut.3.3.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hepner G. W., Booth C. C., Cowan J., Hoffbrand A. V., Mollin D. L. Absorption of crystalline folic acid in man. Lancet. 1968 Aug 10;2(7563):302–306. doi: 10.1016/s0140-6736(68)90523-0. [DOI] [PubMed] [Google Scholar]
- LINDSAY M. K., NORDIN B. E., NORMAN A. P. Late prognosis in coeliac disease. Br Med J. 1956 Jan 7;1(4957):14–18. doi: 10.1136/bmj.1.4957.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MATTHEWS D. M. Observations on the estimation of serum vitamin B12 using Lactobacillus leichmannii. Clin Sci. 1962 Feb;22:101–111. [PubMed] [Google Scholar]
- Mortimer P. E., Stewart J. S., Norman A. P., Booth C. C. Follow-up study of coeliac disease. Br Med J. 1968 Jul 6;3(5609):7–9. doi: 10.1136/bmj.3.5609.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SAKULA J., SHINER M. Coeliac disease with atrophy of the small-intestine mucosa. Lancet. 1957 Nov 2;273(7001):876–877. doi: 10.1016/s0140-6736(57)90010-7. [DOI] [PubMed] [Google Scholar]
- Sheldon W., Tempany E. Small intestine peroral biopsy in coeliac children. Gut. 1966 Oct;7(5):481–489. doi: 10.1136/gut.7.5.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATERS A. H., MOLLIN D. L. Studies on the folic acid activity of human serum. J Clin Pathol. 1961 Jul;14:335–344. doi: 10.1136/jcp.14.4.335. [DOI] [PMC free article] [PubMed] [Google Scholar]