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. 1969 May 24;2(5655):483–485. doi: 10.1136/bmj.2.5655.483

Action of a Pyrimido-pyrimidine Compound on Platelet Behaviour in Vitro

C D Forbes, G P McNicol, A S Douglas
PMCID: PMC1983431  PMID: 5771580

Abstract

A pyrimido-pyrimidine compound (RA433) was found in vitro to be a significantly more potent inhibitor of platelet behaviour than the previously available pyrimido-pyrimidine compound RA8—dipyridamole. In a turbidimetric system RA433 inhibits platelet aggregation induced by adenosine diphosphate, collagen, and noradrenaline; further, in a glass-bead-column technique it is a powerful inhiitor of platelet adhesiveness.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORN G. V. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962 Jun 9;194:927–929. doi: 10.1038/194927b0. [DOI] [PubMed] [Google Scholar]
  2. BORN G. V., CROSS M. J. THE AGGREGATION OF BLOOD PLATELETS. J Physiol. 1963 Aug;168:178–195. doi: 10.1113/jphysiol.1963.sp007185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BORN G. V. Changes in the distribution of phosphorus in platelet-rich plasma during clotting. Biochem J. 1958 Apr;68(4):695–704. doi: 10.1042/bj0680695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BORN G. V., HASLAM R. J., GOLDMAN M. COMPARATIVE EFFECTIVENESS OF ADENOSINE ANALOGUES AS INHIBITORS OF BLOOD-PLATELET AGGREGATION AND AS VASODILATORS IN MAN. Nature. 1965 Feb 13;205:678–680. doi: 10.1038/205678a0. [DOI] [PubMed] [Google Scholar]
  5. BORN G. V., HONOUR A. J., MITCHELL J. R. INHIBITION BY ADENOSINE AND BY 2-CHLOROADENOSINE OF THE FORMATION AND EMBOLIZATION OF PLATELET THROMBI. Nature. 1964 May 23;202:761–765. doi: 10.1038/202761a0. [DOI] [PubMed] [Google Scholar]
  6. BUNAG R. D., DOUGLAS C. R., IMAI S., BERNE R. M. INFLUENCE OF A PYRIMIDOPYRIMIDINE DERIVATIVE ON DEAMINATION OF ADENOSINE BY BLOOD. Circ Res. 1964 Jul;15:83–88. doi: 10.1161/01.res.15.1.83. [DOI] [PubMed] [Google Scholar]
  7. CHANDLER A. B. In vitro thrombotic coagulation of the blood; a method for producing a thrombus. Lab Invest. 1958 Mar-Apr;7(2):110–114. [PubMed] [Google Scholar]
  8. CUNNINGHAM G. M., MCNICOL G. P., DOUGLAS A. S. EFFECT OF ANTICOAGULANT DRUGS ON PLATELET AGGREGATION IN THE CHANDLER'S TUBE. Lancet. 1965 Apr 3;1(7388):729–730. doi: 10.1016/s0140-6736(65)92089-1. [DOI] [PubMed] [Google Scholar]
  9. DUGUID J. B. Mural thrombosis in arteries. Br Med Bull. 1955;11(1):36–38. doi: 10.1093/oxfordjournals.bmb.a069442. [DOI] [PubMed] [Google Scholar]
  10. Elkeles R. S., Hampton J. R., Honour A. J., Mitchell J. R., Prichard J. S. Effect of a pyrimido-pyrimidine compound on platelet behaviour in vitro and in vivo. Lancet. 1968 Oct 5;2(7571):751–754. doi: 10.1016/s0140-6736(68)90952-5. [DOI] [PubMed] [Google Scholar]
  11. Emmons P. R., Harrison M. J., Honour A. J., Mitchell J. R. Effect of a pyrimidopyrimidine derivative on thrombus formation in the rabbit. Nature. 1965 Oct 16;208(5007):255–257. doi: 10.1038/208255a0. [DOI] [PubMed] [Google Scholar]
  12. Emmons P. R., Harrison M. J., Honour A. J., Mitchell J. R. Effect of dipyridamole on human platelet behaviour. Lancet. 1965 Sep 25;2(7413):603–606. doi: 10.1016/s0140-6736(65)90515-5. [DOI] [PubMed] [Google Scholar]
  13. Gray G. R., Wilson P. A., Douglas A. S. The effect on dipyridamole on platelet aggregation and adhesiveness. Scott Med J. 1968 Dec;13(12):409–415. doi: 10.1177/003693306801301202. [DOI] [PubMed] [Google Scholar]
  14. HONOUR A. J., MITCHELL J. R. Platelet clumping in vivo. Nature. 1963 Mar 9;197:1019–1020. doi: 10.1038/1971019b0. [DOI] [PubMed] [Google Scholar]
  15. Hirsh J., McBride J. A., Dacie J. V. Thrombo-embolism and increased platelet adhesiveness in post-splenectomy thrombocytosis. Australas Ann Med. 1966 May;15(2):122–128. doi: 10.1111/imj.1966.15.2.122. [DOI] [PubMed] [Google Scholar]
  16. MITCHELL J. R., SHARP A. A. PLATELET CLUMPING IN VITRO. Br J Haematol. 1964 Jan;10:78–93. doi: 10.1111/j.1365-2141.1964.tb00681.x. [DOI] [PubMed] [Google Scholar]
  17. Prentice C. R., McNicol G. P., Douglas A. S. Effect of normal and atheromatous aortic tissue on platelet aggregation in vitro. J Clin Pathol. 1966 Jul;19(4):343–347. doi: 10.1136/jcp.19.4.343. [DOI] [PMC free article] [PubMed] [Google Scholar]

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