Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1969 Jul 12;3(5662):88–89. doi: 10.1136/bmj.3.5662.88

Ampicillin Levels in Human Bile in the Presence of Biliary Tract Disease

P R Mortimer, D B Mackie, S Haynes
PMCID: PMC1983852  PMID: 5790272

Abstract

Ampicillin levels were measured in the serum and in the bile from both the gall bladder and the common bile duct in patients undergoing surgery for biliary tract diseases. In patients with radiologically non-functioning gall bladders ampicillin was either not present or its concentration was lower than normal. Therapeutic levels were present in the common bile duct of all patients except those with obstruction of the common bile duct. Hence ampicillin fails appreciably to penetrate the obstructed viscus in obstructive biliary tract disease, and it is unlikely to be effective in treating infection associated with this.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AYLIFFE G. A., DAVIES A. AMPICILLIN LEVELS IN HUMAN BILE. Br J Pharmacol Chemother. 1965 Feb;24:189–193. doi: 10.1111/j.1476-5381.1965.tb02094.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BULLOCK W. E. AMPICILLIN THERAPY OF SALMONELLA CARRIERS: A SUMMARY OF LABORATORY AND CLINICAL OBSERVATIONS. Am J Med Sci. 1963 Jul;246:42–47. doi: 10.1097/00000441-196307000-00005. [DOI] [PubMed] [Google Scholar]
  3. Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown D. M., Acred P. "Penbritin"-A New Broad-spectrum Antibiotic. Br Med J. 1961 Jul 22;2(5246):197–198. doi: 10.1136/bmj.2.5246.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HARRISON P. M., STEWART G. T. Excretion of antibiotics in bile. Br J Pharmacol Chemother. 1961 Dec;17:420–423. doi: 10.1111/j.1476-5381.1961.tb01128.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. STEWART G. T., HARRISON P. M. Excretion and re-excretion of a broad-spectrum penicillin in bile. Br J Pharmacol Chemother. 1961 Dec;17:414–419. doi: 10.1111/j.1476-5381.1961.tb01127.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES