Abstract
It has now been shown that normal mice can be used as models for studying the early stages in the development of leprosy. Inoculation into the foot pads of mice of as few as 104 leprosy bacilli leads to infections which spread to distant sites via the blood stream and after two or more years give rise to granulomata and neural damage at the sites of inoculation. Where the tissue response had fully developed it reproduced exactly the histological features of human leprosy in the borderline range.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- REES R. J. LIMITED MULTIPLICATION OF ACID-FAST BACILLI IN THE FOOT-PADS OF MICE INOCULATED WITH MYCOBACTERIUM LEPRAE. Br J Exp Pathol. 1964 Apr;45:207–218. [PMC free article] [PubMed] [Google Scholar]
- Rees R. J. Enhanced susceptibility of thymectomized and irradiated mice to infection with Mycobacterium leprae. Nature. 1966 Aug 6;211(5049):657–658. doi: 10.1038/211657a0. [DOI] [PubMed] [Google Scholar]
- Rees R. J., Waters M. F., Weddell A. G., Palmer E. Experimental lepromatous leprosy. Nature. 1967 Aug 5;215(5101):599–602. doi: 10.1038/215599a0. [DOI] [PubMed] [Google Scholar]
- Rees R. J., Weddell A. G. Biology of the mycobacterioses. Experimental models for studying leprosy. Ann N Y Acad Sci. 1968 Sep 5;154(1):214–236. doi: 10.1111/j.1749-6632.1968.tb16711.x. [DOI] [PubMed] [Google Scholar]
- SHEPARD C. C., MCRAE D. H. MYCOBACTERIUM LEPRAE IN MICE: MINIMAL INFECTIOUS DOSE, RELATIONSHIP BETWEEN STAINING QUALITY AND INFECTIVITY, AND EFFECT OF CORTISONE. J Bacteriol. 1965 Feb;89:365–372. doi: 10.1128/jb.89.2.365-372.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]