Abstract
From 44 to 100% of sera from patients with infectious mononucleosis exhibited the capacity to stimulate colony formation in vitro by mouse bone marrow cells. The proportion of sera with colony-stimulating activity was highest in patients with a short fever period and developing low Paul-Bunnell titres. Patients with a more severe course of the disease generally displayed no, or only weak, colony-stimulating activity in their sera, and also had higher Paul-Bunnell titres. The level of serum colony-stimulating activity tended to fall in the convalescent stages of the disease.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Benyesh-Melnick M., Fern-Bach J., Dessy S., Lewis R. T. Studies on acute leukemia and infectious mononucleosis of childhood. 3. Incidence of spontaneous lymphoblastoid transformation in bone marrow cultures. J Natl Cancer Inst. 1968 Jan;40(1):111–122. [PubMed] [Google Scholar]
- DAVIDSOHN I., STERN K., KASHIWAGI C. The differential test for infectious mononucleosis. Am J Clin Pathol. 1951 Dec;21(12):1101–1113. doi: 10.1093/ajcp/21.12.1101. [DOI] [PubMed] [Google Scholar]
- Foster R., Jr, Metcalf D., Robinson W. A., Bradley T. R. Bone marrow colony stimulating activity in human sera. Results of two independent surveys in Buffalo and Melbourne. Br J Haematol. 1968 Aug;15(2):147–159. doi: 10.1111/j.1365-2141.1968.tb01524.x. [DOI] [PubMed] [Google Scholar]
- Metcalf D., Foster R. Bone marrow colony-stimulating activity of serum from mice with viral-induced leukemia. J Natl Cancer Inst. 1967 Dec;39(6):1235–1245. [PubMed] [Google Scholar]