Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1968 Aug 3;3(5613):287–290. doi: 10.1136/bmj.3.5613.287

Viral Antibody Levels and Clinical Status in Acute Exacerbations of Chronic Bronchitis: a Controlled Prospective Study*

A C Stenhouse
PMCID: PMC1986246  PMID: 4299087

Abstract

A controlled prospective study was made of a group of patients with chronic bronchitis, in which serum antibodies against a group of viruses and Mycoplasma pneumoniae were estimated at regular intervals. Sixteen significant rises in antibody titre were shown, of which eight were associated with clinical acute exacerbations of bronchitis. In individual patients no correlation was found between the number of acute exacerbations or the aetiological agent and persistent change in ventilatory function as expressed by the F.E.V.0.75.

This study was compared with the results of a previous parallel investigation of the same patients done to study the significance of rhinovirus infections. In the present investigation 12% of the acute exacerbations were associated with the 11 agents tested compared with 14% associated with rhinoviruses in the earlier work.

Full text

PDF
287

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CARILLI A. D., GOHD R. S., GORDON W. A VIROLOGIC STUDY OF CHRONIC BRONCHITIS. N Engl J Med. 1964 Jan 16;270:123–127. doi: 10.1056/NEJM196401162700303. [DOI] [PubMed] [Google Scholar]
  2. Chanock R. M., Mufson M. A., Johnson K. M. Comparative biology and ecology of human virus and Mycoplasma respiratory pathogens. Prog Med Virol. 1965;7:208–252. [PubMed] [Google Scholar]
  3. Howard P. Evolution of the ventilatory capacity in chronic bronchitis. Br Med J. 1967 Aug 12;3(5562):392–395. doi: 10.1136/bmj.3.5562.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. MURDOCH J. M., LECKIE W. J., DOWNIE J., SWAIN R. H., GOULD J. C. An evaluation of continuous antibiotic therapy in chronic bronchitis. Br Med J. 1959 Dec 12;2(5162):1277–1285. doi: 10.1136/bmj.2.5162.1277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ross C. A., McMichael S., Eadie M. B., Lees A. W., Murray E. A., Pinkerton I. Infective agents and chronic bronchitis. Thorax. 1966 Sep;21(5):461–464. doi: 10.1136/thx.21.5.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. SOMMERVILLE R. G. RESPIRATORY SYNCYTIAL VIRUS IN ACUTE EXACERBATIONS OF CHRONIC BRONCHITIS. Lancet. 1963 Dec 14;2(7320):1247–1248. doi: 10.1016/s0140-6736(63)90894-8. [DOI] [PubMed] [Google Scholar]
  7. STARK J. E., HEATH R. B., CURWEN M. P. INFECTION WITH INFLUENZA AND PARAINFLUENZA VIRUSES IN CRONIC BRONCHITIS. Thorax. 1965 Mar;20:124–127. doi: 10.1136/thx.20.2.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. STUART-HARRIS C. H., POWNALL M., SCOTHORNE C. M., FRANKS Z. The factor of infection in chronic bronchitis. Q J Med. 1953 Apr;22(86):121–132. [PubMed] [Google Scholar]
  9. Stenhouse A. C. Rhinovirus infection in acute exacerbations of chronic bronchitis: a controlled prospective study. Br Med J. 1967 Aug 19;3(5563):461–463. doi: 10.1136/bmj.3.5563.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. WALKER W. C., DOUGLAS A. C., LECKIE W. J., PINES A., GRANT I. W. Respiratory complications of influenza. Lancet. 1958 Mar 1;1(7018):449–454. doi: 10.1016/s0140-6736(58)90762-1. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES