Abstract
Three patients developed autoimmune haemolytic anaemia while being treated with mefenamic acid. In each case the autoimmune haemolytic anaemia was of the warm antibody γG type, and the antibodies had some rhesus specificity. All three patients recovered when the drug was withdrawn.
Attempts to inhibit or enhance the activity of the antibody in vitro were unsuccessful.
Direct antihuman globulin tests were made in.the red cells of 36 patients receiving long-term mefenamic acid therapy, but only one was found to be transitorily positive.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barnardo D. E., Currey H. L., Mason R. M., Fox W. R., Weatherall M. Mefenamic acid and flufenamic acid compared with aspirin and phenylbutazone in rheumatoid arthritis. Br Med J. 1966 Aug 6;2(5509):342–343. doi: 10.1136/bmj.2.5509.342. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CAHILL W. J., HILL R. D., JESSOP J., KENDALL P. H. TRIAL OF MEFENAMIC ACID. Ann Phys Med. 1965 Feb;8:26–29. doi: 10.1093/rheumatology/8.1.26. [DOI] [PubMed] [Google Scholar]
- Carstairs K. C., Breckenridge A., Dollery C. T., Worlledge S. M. Incidence of a positive direct coombs test in patients on alpha-methyldopa. Lancet. 1966 Jul 16;2(7455):133–135. doi: 10.1016/s0140-6736(66)92422-6. [DOI] [PubMed] [Google Scholar]
- LoBuglio A. F., Jandl J. H. The nature of the alpha-methyldopa red-cell antibody. N Engl J Med. 1967 Mar 23;276(12):658–665. doi: 10.1056/NEJM196703232761203. [DOI] [PubMed] [Google Scholar]
- Louis W. J., Doyle A. E., Jerums G., Kincaid-Smith P. Methyldopa and haemolytic anaemia. Med J Aust. 1967 Jul 15;2(3):104–106. doi: 10.5694/j.1326-5377.1966.tb72744.x. [DOI] [PubMed] [Google Scholar]
- Myles A. B., Bacon P. A., Williams K. A. Mefenamic acid in rheumatoid arthritis. Ann Rheum Dis. 1967 Nov;26(6):494–498. doi: 10.1136/ard.26.6.494. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Worlledge S. M., Carstairs K. C., Dacie J. V. Autoimmune haemolytic anaemia associated with alpha-methyldopa therapy. Lancet. 1966 Jul 16;2(7455):135–139. doi: 10.1016/s0140-6736(66)92423-8. [DOI] [PubMed] [Google Scholar]