Abstract
The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. There was no differential effect of any of the secretagogues tested on the secretion of 5-HT and histamine. Amitriptyline prevented the secretion of histamine in response to stimulation by neurotensin, substance P, somatostatin or compound 48/80 but was without effect on the secretion of endogenous 5-HT.
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Selected References
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- Carraway R., Cochrane D. E., Lansman J. B., Leeman S. E., Paterson B. M., Welch H. J. Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels. J Physiol. 1982 Feb;323:403–414. doi: 10.1113/jphysiol.1982.sp014080. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cochrane D. E., Douglas W. W., Mouri T., Nakazato Y. Calcium and stimulus-secretion coupling in the adrenal medulla: contrasting stimulating effects of the ionophores X-537A and A23187 on catecholamine output. J Physiol. 1975 Nov;252(2):363–378. doi: 10.1113/jphysiol.1975.sp011148. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foreman J. C. The pharmacological control of immediate hypersensitivity. Annu Rev Pharmacol Toxicol. 1981;21:63–81. doi: 10.1146/annurev.pa.21.040181.000431. [DOI] [PubMed] [Google Scholar]
- Granier C., van Rietschoten J., Kitabgi P., Poustis C., Freychet P. Synthesis and characterization of neurotensin analogues for structure/activity relationship studies. Acetyl-neurotensin-(8--13) is the shortest analogue with full binding and pharmacological activities. Eur J Biochem. 1982 May;124(1):117–124. doi: 10.1111/j.1432-1033.1982.tb05913.x. [DOI] [PubMed] [Google Scholar]
- Irman-Florjanc T., Erjavec F. Compound 48/80 and substance P induced release of histamine and serotonin from rat peritoneal mast cells. Agents Actions. 1983 Apr;13(2-3):138–141. doi: 10.1007/BF01967317. [DOI] [PubMed] [Google Scholar]
- Sperk G. Simultaneous determination of serotonin, 5-hydroxindoleacetic acid, 3,4-dihydroxyphenylacetic acid and homovanillic acid by high performance liquid chromatography with electrochemical detection. J Neurochem. 1982 Mar;38(3):840–843. doi: 10.1111/j.1471-4159.1982.tb08708.x. [DOI] [PubMed] [Google Scholar]
- Theoharides T. C., Bondy P. K., Tsakalos N. D., Askenase P. W. Differential release of serotonin and histamine from mast cells. Nature. 1982 May 20;297(5863):229–231. doi: 10.1038/297229a0. [DOI] [PubMed] [Google Scholar]