Abstract
The effects of phenolphthalein on the formation of histamine, 5-hydroxytryptamine(5-HT) and prostaglandin-like material by rat intestine were examined in vivo. Phenolphthalein, in a dose that causes laxation increased the formation of histamine, 5-HT and prostaglandin-like material, and indomethacin reduced these increases. The data support the idea that the laxative effect of phenolphthalein is due to increased intestinal production of prostaglandin, histamine and 5-HT.
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Selected References
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- Bennett A., Charlier E. M. Evidence against the release of prostaglandin-like material from isolated intestinal tissue by pure cholera toxin. Prostaglandins. 1977 Mar;13(3):431–436. doi: 10.1016/0090-6980(77)90023-5. [DOI] [PubMed] [Google Scholar]
- Bennett A., Friedmann C. A., Vane J. R. Release of prostaglandin E-1 from the rat stomach. Nature. 1967 Dec 2;216(5118):873–876. doi: 10.1038/216873a0. [DOI] [PubMed] [Google Scholar]
- Beubler E., Juan H. Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin E release by the rat colon. J Pharm Pharmacol. 1979 Oct;31(10):681–685. doi: 10.1111/j.2042-7158.1979.tb13628.x. [DOI] [PubMed] [Google Scholar]
- Cohen M. M. The effect of cathartics on prostaglandin synthesis by rat gastro-intestinal tract. Prostaglandins Leukot Med. 1982 Apr;8(4):389–397. doi: 10.1016/0262-1746(82)90062-2. [DOI] [PubMed] [Google Scholar]
- Herman A. G., Vane J. R. Effect of indomethacin on endotoxin-induced production of prostaglandins in the isolated rabbit jejunum. Adv Prostaglandin Thromboxane Res. 1976;2:557–560. [PubMed] [Google Scholar]
- Thompson J. H., Angulo M. The effect of prostaglandins on gastrointestinal serotonin in the rat. Eur J Pharmacol. 1968 Sep;4(2):224–227. doi: 10.1016/0014-2999(68)90181-7. [DOI] [PubMed] [Google Scholar]
- Vischer P., Casals-Stenzel J. Influence of prostacyclin and indomethacin on castor oil-induced gastrointestinal effects in rats. J Pharm Pharmacol. 1983 Mar;35(3):152–156. doi: 10.1111/j.2042-7158.1983.tb04295.x. [DOI] [PubMed] [Google Scholar]